2023
A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures
Kuhn R, Barrett A, Desilva A, Harris E, Kramer L, Montgomery R, Pierson T, Sette A, Diamond M. A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures. The Journal Of Infectious Diseases 2023, 228: s398-s413. PMID: 37849402, PMCID: PMC10582523, DOI: 10.1093/infdis/jiad193.Peer-Reviewed Original ResearchConceptsFamily of positive-strand RNA virusesPositive-strand RNA virusesSelf-limited febrile syndromeSpread of flavivirusesRNA virusesPrototype flavivirusDevelopment of vaccinesFebrile syndromePandemic potentialYellow fever virusFlaviviridae familyHuman infectionsViscerotropic diseaseZika virusTick vectorFever virusFlavivirusesDengue virusVaccineVirusGenus
2014
Effect of aging on microRNAs and regulation of pathogen recognition receptors
Olivieri F, Procopio AD, Montgomery RR. Effect of aging on microRNAs and regulation of pathogen recognition receptors. Current Opinion In Immunology 2014, 29: 29-37. PMID: 24769423, PMCID: PMC4119513, DOI: 10.1016/j.coi.2014.03.006.Peer-Reviewed Original ResearchConceptsInnate immune recognitionImmune innate responseResolution of inflammationPathogen recognition receptorsTLR signalsUnderstanding of immunosenescenceProinflammatory responseImmune responseNF-κBInnate responseImmune recognitionRecognition receptorsActive investigationImmunosenescenceDownstream effectorsRecent studiesNegative regulatorSimilar regulatory activitiesResponseMiRNAsInflammationMicroRNAsAging-associated miRNAsVaccine