2024
Interferon-stimulated neutrophils as a predictor of immunotherapy response
Benguigui M, Cooper T, Kalkar P, Schif-Zuck S, Halaban R, Bacchiocchi A, Kamer I, Deo A, Manobla B, Menachem R, Haj-Shomaly J, Vorontsova A, Raviv Z, Buxbaum C, Christopoulos P, Bar J, Lotem M, Sznol M, Ariel A, Shen-Orr S, Shaked Y. Interferon-stimulated neutrophils as a predictor of immunotherapy response. Cancer Cell 2024, 42: 253-265.e12. PMID: 38181798, PMCID: PMC10864002, DOI: 10.1016/j.ccell.2023.12.005.Peer-Reviewed Original ResearchImmunotherapy responseNon-small cell lung cancerAnti-PD1 responseAnti-PD1 therapyCohort of patientsNon-responsive tumorsCell lung cancerAnti-cancer immunotherapyPre-clinical findingsBlood-borne biomarkersCytotoxic TLung cancerPredictive biomarkersCurrent biomarkersTreatment responseNeutrophilsLY6EBiomarkersActive biomarkersPatientsMiceFurther mechanistic understandingActivationResponseImmunotherapy
1989
Molecular basis of mouse Himalayan mutation
Kwon B, Halaban R, Chintamaneni C. Molecular basis of mouse Himalayan mutation. Biochemical And Biophysical Research Communications 1989, 161: 252-260. PMID: 2567165, DOI: 10.1016/0006-291x(89)91588-x.Peer-Reviewed Original ResearchConceptsAmino acid 420Histidine residuesAmino acidsTemperature-sensitive tyrosinaseCDNA libraryHimalayan miceMouse tyrosinaseInteresting mutantsNucleotide sequenceB proteinMolecular basisTyrosinase geneTyrosinase cDNAArginine residuesTyrosinase moleculesHuman tyrosinaseG changeResiduesMutationsTyrosinaseMutantsCDNAGenesMiceTyrosinase inhibitors
1988
The BULT Melanoma: A Spontaneous Transplantable Tumor in Mice
QUEVEDO W, DYCKMAN J, HALABAN R, MOELLMANN G, COWAN J, HOLSTEIN T. The BULT Melanoma: A Spontaneous Transplantable Tumor in Mice. Pigment Cell & Melanoma Research 1988, 1: 124-131. DOI: 10.1111/j.1600-0749.1988.tb00802.x.Peer-Reviewed Original ResearchMelanoma cellsSmall black noduleAdult female miceMelanin-laden macrophagesStrains of miceLymph nodesFemale micePrimary melanomaSubcutaneous graftsHistological examinationCH miceTransplantable tumorsMelanomaSpontaneous deathTransplantation siteBlack noduleGeneral histologyMiceMouse melanomaHair folliclesModal chromosome numberHind legsTumorsCancer researchAutophagic vacuoles