An evolutionarily conserved gene family encodes proton-selective ion channels
Tu YH, Cooper AJ, Teng B, Chang RB, Artiga DJ, Turner HN, Mulhall EM, Ye W, Smith AD, Liman ER. An evolutionarily conserved gene family encodes proton-selective ion channels. Science 2018, 359: 1047-1050. PMID: 29371428, PMCID: PMC5845439, DOI: 10.1126/science.aao3264.Peer-Reviewed Original ResearchConceptsProton-selective ion channelIon channelsProton channelComparative transcriptome analysisTaste receptor cellsWidespread tissue distributionEvolutionary conservationEukaryotic cellsGene familyMurine geneTranscriptome analysisReceptor cellsElectrical signalingProton conductanceBroader roleMouse taste receptor cellsTissue distributionCellsOrthologsGenesSignalingProteinConservationPhysiologyFamily