JAK/STAT signaling pathway affects CCR5 expression in human CD4+ T cells
Wang L, Yukselten Y, Nuwagaba J, Sutton R. JAK/STAT signaling pathway affects CCR5 expression in human CD4+ T cells. Science Advances 2024, 10: eadl0368. PMID: 38507500, PMCID: PMC10954213, DOI: 10.1126/sciadv.adl0368.Peer-Reviewed Original ResearchMeSH KeywordsCD4-Positive T-LymphocytesHIV InfectionsHIV-1HumansJanus KinasesReceptors, CCR5Signal TransductionSTAT Transcription FactorsT-LymphocytesConceptsCD4<sup>+</sup> T cellsT cellsCCR5 expressionPrimary CD4<sup>+</sup> T cellsCD4+ T cellsHuman CD4+ T cellsHuman primary CD4<sup>+</sup> T cellsGlucocorticoid-regulated kinase 1HIV cure agendaHIV co-receptorsSignaling pathwayCCR5 levelsJAK/STAT inhibitor tofacitinibViremic patientsHIV patientsHIV infectionInhibitor tofacitinibJAK/STAT signaling pathwayCCR5Co-receptorHIVProtein levelsCCR2/CCR5Adverse effectsDown-regulation