2024
The gratitude paradox
Chisholm‐Burns M, Formica R. The gratitude paradox. Journal Of Internal Medicine 2024, 295: 712-714. PMID: 38575552, DOI: 10.1111/joim.13788.Peer-Reviewed Original ResearchHumansUse of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians
Wiseman A, Alhamad T, Alloway R, Concepcion B, Cooper M, Formica R, Klein C, Kumar V, Leca N, Shihab F, Taber D, Mulnick S, Bushnell D, Hadi M, Bunnapradist S. Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians. Annals Of Transplantation 2024, 29: e943498-1-e943498-13. PMID: 38526543, PMCID: PMC10944009, DOI: 10.12659/aot.943498.Peer-Reviewed Original ResearchConceptsLCP-tacrolimusImmediate-release tacrolimusKidney transplantationFirst-line optionKidney transplant recipientsRandomized clinical trialsDe novo settingTacrolimus formulationReview available dataEvidence-based recommendationsTrough levelsOnce-dailyTransplant recipientsClinical decision-makingOptimal doseClinical trialsExpert cliniciansConsensus statementTransplant expertsStrength of evidenceClinical practiceKidneyTacrolimusDe novoDelphi consensus survey
2023
Physician Preferences when Selecting Candidates for Lower-Quality Kidney Offers
Sepulveda J, Mehrotra S, Yang J, Schantz K, Becker Y, Formica R, Ladner D, Kaufman D, Friedewald J. Physician Preferences when Selecting Candidates for Lower-Quality Kidney Offers. Clinical Journal Of The American Society Of Nephrology 2023, 18: 1599-1609. PMID: 37729938, PMCID: PMC10723918, DOI: 10.2215/cjn.0000000000000302.Peer-Reviewed Original ResearchConceptsCold ischemia timePanel reactive antibodyIschemia timeMarginal kidneysEjection fractionReactive antibodiesRecipient characteristicsPost-transplant survival scoreSignificant associationKidney Donor Profile IndexKarnofsky performance scoreSerum creatinine levelsHistory of diabetesLow-quality kidneysHLA mismatchesPerformance statusRecipient ageCreatinine levelsDiabetes statusHLA matchCirculatory deathKidney qualityYounger recipientsDonor ageDiscrete choice experimentStakeholders’ perspectives on transplant metrics: the 2022 Scientific Registry of Transplant Recipients’ consensus conference
Snyder J, Schaffhausen C, Hart A, Axelrod D, Dils D, Formica R, Gaber A, Hunt H, Jones J, Mohan S, Patzer R, Pinney S, Ratner L, Slaker D, Stewart D, Stewart Z, Van Slyck S, Kasiske B, Hirose R, Israni A. Stakeholders’ perspectives on transplant metrics: the 2022 Scientific Registry of Transplant Recipients’ consensus conference. American Journal Of Transplantation 2023, 23: 875-890. PMID: 36958628, DOI: 10.1016/j.ajt.2023.03.012.Peer-Reviewed Original ResearchThe Unintended Consequences of Changes to the Organ Allocation Policy
Formica R, Schold J. The Unintended Consequences of Changes to the Organ Allocation Policy. Journal Of The American Society Of Nephrology 2023, 34: 14-16. PMID: 36719146, PMCID: PMC10101628, DOI: 10.1681/asn.0000000000000009.Peer-Reviewed Original Research
2022
A Composite End Point of Graft Status and eGFR at 1 Year to Improve the Scientific Registry of Transplant Recipients’ Five-Tier Rating System
Wang K, Deng Y, Stewart D, Formica R. A Composite End Point of Graft Status and eGFR at 1 Year to Improve the Scientific Registry of Transplant Recipients’ Five-Tier Rating System. Journal Of The American Society Of Nephrology 2022, 33: 1613-1624. PMID: 35537779, PMCID: PMC9342646, DOI: 10.1681/asn.2022010078.Peer-Reviewed Original ResearchConceptsComposite end pointTraditional end pointsTransplant programsEnd pointAllograft functionGraft survivalScientific RegistryFive-tier systemLong-term graft outcomeDonor graft survivalKidney transplant programAllograft failureAllograft survivalGraft outcomeTransplant recipientsGraft statusGraft failureEGFR differenceSRTR dataSurvival rateEGFRSurvivalRegistryMeaningful differencesConcept study
2021
It Is Time for Patient-Reported Outcome Measures to Be Included in the Approval Process for Solid Organ Transplant Medications
Formica R, Turgeon N. It Is Time for Patient-Reported Outcome Measures to Be Included in the Approval Process for Solid Organ Transplant Medications. Journal Of The American Society Of Nephrology 2021, 32: 2984-2986. PMID: 36734821, PMCID: PMC8638394, DOI: 10.1681/asn.2021081136.Peer-Reviewed Original Research
2020
Physician and patient acceptance of policies to reduce kidney discard
Mehrotra S, Schantz K, Friedewald JJ, Ladner DP, Becker Y, Formica R, Barah M, Gu J, Gordon EJ. Physician and patient acceptance of policies to reduce kidney discard. Clinical Transplantation 2020, 34: e14054. PMID: 32738167, PMCID: PMC7929781, DOI: 10.1111/ctr.14054.Peer-Reviewed Original ResearchConceptsDeceased donor kidneysMajority of physiciansDonor kidneysKidney allocation policyShortage of kidneysRisk of discardAggressive centersGraft failureSurvival benefitSuitable patientsTransplant physiciansPatient acceptancePatientsKidneyPhysiciansPatient organizationsProfessional societiesKDPITransplantationMajorityMonthsA call to action: Feasible strategies to reduce the discard of transplantable kidneys in the United States
Stewart ZA, Shah SA, Formica RN, Kandaswamy R, Paramesh AS, Friedman J, Squires R, Cooper M, Axelrod DA. A call to action: Feasible strategies to reduce the discard of transplantable kidneys in the United States. Clinical Transplantation 2020, 34: e13990. PMID: 32621660, DOI: 10.1111/ctr.13990.Peer-Reviewed Original ResearchConceptsOrgan utilizationHigh-kidney donor profile index kidneysAcceptable post-transplant outcomesLow-risk organPost-transplant outcomesCold ischemic timeCold ischemia timeDeceased donor kidneysKidney allocation systemHigher transplant ratesNew allocation policyOrgan acceptanceIschemic timeDonor kidneysIschemia timeTransplant ratesOrgan discardRisk organsPractice patternsTransplantable kidneysClinical practicePathological interpretationGeographic sharingKidneyFinancial barriersOutpatient Management of the Kidney Transplant Recipient during the SARS-CoV-2 Virus Pandemic
Gleeson SE, Formica RN, Marin EP. Outpatient Management of the Kidney Transplant Recipient during the SARS-CoV-2 Virus Pandemic. Clinical Journal Of The American Society Of Nephrology 2020, 15: cjn.04510420. PMID: 32345749, PMCID: PMC7274284, DOI: 10.2215/cjn.04510420.Peer-Reviewed Original ResearchThe Broader Sharing of Deceased Donor Kidneys Is an Ethical and Legal Imperative
Klarman SE, Formica RN. The Broader Sharing of Deceased Donor Kidneys Is an Ethical and Legal Imperative. Journal Of The American Society Of Nephrology 2020, 31: asn.2020020121. PMID: 32312798, PMCID: PMC7269362, DOI: 10.1681/asn.2020020121.Commentaries, Editorials and LettersAdvancing American Kidney Health—New Opportunities for Collaborative Care
Rivara MB, Formica RN, Mehrotra R. Advancing American Kidney Health—New Opportunities for Collaborative Care. The American Journal Of Medicine 2020, 133: e335-e337. PMID: 32145208, DOI: 10.1016/j.amjmed.2020.01.036.Peer-Reviewed Original ResearchModulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin
Abdallah CG, Averill LA, Gueorguieva R, Goktas S, Purohit P, Ranganathan M, Sherif M, Ahn KH, D’Souza D, Formica R, Southwick SM, Duman RS, Sanacora G, Krystal JH. Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin. Neuropsychopharmacology 2020, 45: 990-997. PMID: 32092760, PMCID: PMC7162891, DOI: 10.1038/s41386-020-0644-9.Peer-Reviewed Original ResearchConceptsAntidepressant effectsKetamine administrationRapamycin pretreatmentMontgomery-Åsberg Depression Rating ScaleDouble-blind cross-over designBenefits of ketamineRobust antidepressant effectsKetamine's antidepressant effectsMajor depressive episodeDepression Rating ScaleCross-over designKetamine exertsOral rapamycinRemission rateDepressive episodePlacebo 2Ketamine 0.5Local blockadeDepressed patientsIntravenous administrationTreatment daysDepression relapseDepression severityKetamineRating Scale
2019
Should the United States employ free market practices to solve the hidden public health crisis of chronic kidney disease?
Formica RN, Gill JS. Should the United States employ free market practices to solve the hidden public health crisis of chronic kidney disease? American Journal Of Transplantation 2019, 20: 1217-1218. PMID: 31746545, DOI: 10.1111/ajt.15718.Peer-Reviewed Original ResearchEconomic Evaluation of Extending Medicare Immunosuppressive Drug Coverage for Kidney Transplant Recipients in the Current Era
Kadatz M, Gill JS, Gill J, Formica RN, Klarenbach S. Economic Evaluation of Extending Medicare Immunosuppressive Drug Coverage for Kidney Transplant Recipients in the Current Era. Journal Of The American Society Of Nephrology 2019, 31: 218-228. PMID: 31704739, PMCID: PMC6934999, DOI: 10.1681/asn.2019070646.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsQuality-adjusted life yearsTransplant recipientsTransplant survivalDrug coverageMedicare coverageTransplant failureImmunosuppressant drugsAdditional quality-adjusted life yearCohort of MedicareMultivariable survival analysisIncremental cost-utility ratioBetter patient outcomesCost-utility ratioImmunosuppressant medicationsTransplant functionImmunosuppressive drugsPatient outcomesMedicare payersSurvival analysisLife yearsIncremental costRecipientsSurvivalDrugsTransplantation of Kidneys from HCV Viremic Donors in the United States: A Missed Opportunity to Inform Clinical Decision Making and Health Policy
Gill JS, Formica RN, Levitsky J. Transplantation of Kidneys from HCV Viremic Donors in the United States: A Missed Opportunity to Inform Clinical Decision Making and Health Policy. Journal Of The American Society Of Nephrology 2019, 30: 1778-1780. PMID: 31570540, PMCID: PMC6779353, DOI: 10.1681/asn.2019070726.Peer-Reviewed Original ResearchSafety, pharmacokinetics, and pharmacodynamic activity of obinutuzumab, a type 2 anti-CD20 monoclonal antibody for the desensitization of candidates for renal transplant
Redfield RR, Jordan SC, Busque S, Vincenti F, Woodle ES, Desai N, Reed EF, Tremblay S, Zachary AA, Vo AA, Formica R, Schindler T, Tran H, Looney C, Jamois C, Green C, Morimoto A, Rajwanshi R, Schroeder A, Cascino MD, Brunetta P, Borie D. Safety, pharmacokinetics, and pharmacodynamic activity of obinutuzumab, a type 2 anti-CD20 monoclonal antibody for the desensitization of candidates for renal transplant. American Journal Of Transplantation 2019, 19: 3035-3045. PMID: 31257724, PMCID: PMC6899639, DOI: 10.1111/ajt.15514.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntibodies, Monoclonal, HumanizedAntigens, CD20Antineoplastic Agents, ImmunologicalCohort StudiesDesensitization, ImmunologicFemaleFollow-Up StudiesGraft SurvivalHLA AntigensHumansKidney Failure, ChronicKidney TransplantationMaleMaximum Tolerated DoseMiddle AgedPatient SelectionPrognosisRisk FactorsTissue DistributionYoung AdultConceptsB-cell depletionSerious adverse eventsIntravenous immunoglobulinCell depletionAdverse eventsOpen-label phase 1b studyType 2Doses of IVIGIncomplete B cell depletionPanel reactive antibody scorePeripheral B-cell depletionEnd-stage renal diseasePhase 1b studyAnti-HLA antibodiesRetroperitoneal lymph nodesSingle antigen beadsTime of transplantCD20 monoclonal antibodyMedian followRenal transplantKidney transplantMost patientsWeek 24Lymph nodesRenal diseaseESKD Risk in Living Kidney Donors “Like Me”
Newell KA, Formica RN. ESKD Risk in Living Kidney Donors “Like Me”. Clinical Journal Of The American Society Of Nephrology 2019, 14: 970-971. PMID: 31278113, PMCID: PMC6625628, DOI: 10.2215/cjn.06010519.Peer-Reviewed Original Research
2018
Report of National Kidney Foundation Consensus Conference to Decrease Kidney Discards
Cooper M, Formica R, Friedewald J, Hirose R, O’Connor K, Mohan S, Schold J, Axelrod D, Pastan S. Report of National Kidney Foundation Consensus Conference to Decrease Kidney Discards. Clinical Transplantation 2018, 33: e13419. PMID: 30345720, DOI: 10.1111/ctr.13419.Peer-Reviewed Original ResearchAnd equal access for all? The future of deceased donor kidney allocation
Formica RN. And equal access for all? The future of deceased donor kidney allocation. American Journal Of Transplantation 2018, 18: 1837-1838. PMID: 29878578, DOI: 10.1111/ajt.14964.Peer-Reviewed Original Research