Variations in Antithrombotic Combinations and Prescription Durations After Lower Extremity Revascularization in Patients With Peripheral Arterial Disease
Wells N, Alameddine D, Dhanda U, Tran L, Silva D, Slade M, Guzman R, Chaar C. Variations in Antithrombotic Combinations and Prescription Durations After Lower Extremity Revascularization in Patients With Peripheral Arterial Disease. Journal Of Vascular Surgery 2024, 80: e135-e136. DOI: 10.1016/j.jvs.2024.07.076.Peer-Reviewed Original ResearchThe Incidence and Impact of Cardiac Function Decline after Lower Extremity Revascularization
Jamil Y, Huttler J, Alameddine D, Wu Z, Mena-Hurtado C, Velazquez E, Guzman R, Ochoa Chaar C. The Incidence and Impact of Cardiac Function Decline after Lower Extremity Revascularization. Annals Of Vascular Surgery 2024 PMID: 39343374, DOI: 10.1016/j.avsg.2024.07.119.Peer-Reviewed Original ResearchCardiac functional declineStable cardiac functionLower extremity revascularizationPeripheral arterial diseaseCardiac functionFollow-upExtremity revascularizationFunctional declineElectronic records of patientsKaplan-Meier analysisRecords of patientsMode of revascularizationAdverse limb eventsLower-extremity revascularizationTransthoracic echocardiogramReintervention rateHeart failureDiabetes mellitusPeriprocedural bleedingPatient characteristicsArtery diseasePatientsLimb eventsIncreased mortalityRevascularizationPresentation and patterns of reinterventions after revascularization in patients with premature Peripheral Arterial Disease
Sivakumar A, Satam K, Wu Z, Alameddine D, Aboian E, Chaer R, Schermerhorn M, Moreira C, Guzman R, Ochoa Chaar C. Presentation and patterns of reinterventions after revascularization in patients with premature Peripheral Arterial Disease. Journal Of Vascular Surgery 2024 PMID: 39002606, DOI: 10.1016/j.jvs.2024.07.021.Peer-Reviewed Original ResearchPremature peripheral arterial diseaseLower extremity revascularizationOlder patientsPeripheral arterial diseaseArtery diseaseRetrospective review of consecutive patientsReview of consecutive patientsDistressed Communities IndexAge of presentationFrequency of reinterventionsEnd-stage renal diseaseKaplan-Meier curvesOutcomes of lower extremity revascularizationLong-term outcomesCoronary artery diseaseMALE-free survivalAdverse limb eventsOverall survivalReintervention rateConsecutive patientsFrequent reinterventionsPerioperative complicationsRetrospective reviewNo significant differenceInstitutional experienceAbstract 146: Phosphodiesterase 10A Mediates Arterial Calcification Through A P38/MAPK-MMP3 Signaling
Jin Y, Xie Y, Berezowitz A, Davis S, Flores A, Wang X, Guzman R, Cai Y. Abstract 146: Phosphodiesterase 10A Mediates Arterial Calcification Through A P38/MAPK-MMP3 Signaling. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44 DOI: 10.1161/atvb.44.suppl_1.146.Peer-Reviewed Original ResearchVascular smooth muscle cellsChronic kidney diseasePeripheral arterial diseaseArtery calcificationInhibition of PDE10AMedial arterial calcificationVascular calcificationAssociated with increased cardiovascular morbidityCalcifying vascular smooth muscle cellsMatrix metallopeptidaseSmooth muscle cellsVSMCs in vitroCyclic nucleotides cAMPArteries in vivoMMP-3 upregulationCardiovascular morbidityCalcification in vivoArtery diseaseVon Kossa stainingKidney diseaseMuscle cellsRodent modelsVSMC calcificationInducible isoformCalcium assayPerioperative complications of minor and major reinterventions for peripheral arterial disease.
Huttler J, Satam K, Kim T, Zhuo H, Zhang Y, Aboian E, Guzman R, Chaar C. Perioperative complications of minor and major reinterventions for peripheral arterial disease. Vascular 2024, 17085381241246907. PMID: 38597200, DOI: 10.1177/17085381241246907.Peer-Reviewed Original ResearchCatheter-directed thrombolysisLower-extremity revascularizationPeripheral arterial diseaseSurgical reinterventionPerioperative morbidityPerioperative outcomesAssociated with greater perioperative morbiditySubgroup analysisArtery diseaseReturn to the ORRetrospective review of electronic medical recordsPost-operative bleedingReview of electronic medical recordsIncreased perioperative morbidityAcute renal failureVascular Surgery guidelinesTertiary care centerSurgery guidelinesOpen surgeryPerioperative mortalityPerioperative complicationsRetrospective reviewWound infectionRenal failureReinterventionAnticoagulation in Patients with Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization
Kim T, DeWan A, Murray M, Wang H, Mani A, Mena-Hurtado C, Guzman R, Ochoa Chaar C. Anticoagulation in Patients with Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization. Annals Of Vascular Surgery 2024, 105: 150-157. PMID: 38593922, DOI: 10.1016/j.avsg.2024.02.006.Peer-Reviewed Original ResearchPremature peripheral arterial diseaseAntiplatelet therapyVascular Quality InitiativeArtery diseaseAdjunct to antiplatelet therapyReturn to the operating roomPost-operative anticoagulationCompared to patientsPostoperative antiplatelet therapyOne-year outcomesCongestive heart failureLower extremity revascularizationMajor adverse limb eventsCoronary artery diseaseEffects of anticoagulantsAmputation-free survivalEarly onset of diseaseAdverse limb eventsPeripheral vascular interventionsOnset of diseasePeripheral arterial diseaseLower-extremity revascularizationPropensity score matchingPerioperative mortalityBaseline characteristicsSmooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification
Xie Y, Lin T, Jin Y, Berezowitz A, Wang X, Lu J, Cai Y, Guzman R. Smooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification. Cardiovascular Research 2024, 120: 658-670. PMID: 38454645, PMCID: PMC11074797, DOI: 10.1093/cvr/cvae035.Peer-Reviewed Original ResearchSmooth muscle cellsPeripheral arterial diseaseVascular smooth muscle cellsMedial calcificationMMP-3Osteogenic transformationRodent modelsAssociated with increased morbiditySmooth muscle cell calcificationChronic kidney diseaseEx vivo organ culture modelMMP-3 expressionOrgan culture modelMedial arterial calcificationTargeting MMP-3Matrix metalloproteinase 3MMP-3 proteinArtery calcificationArtery diseaseKidney diseaseVascular calcificationMuscle cellsTherapeutic strategiesCalcification mediumVitamin D3