DRONE: Direct Tracking of DNA Cytidine Deamination and Other DNA Modifying Activities
Sasaki T, Kudalkar SN, Bertoletti N, Anderson KS. DRONE: Direct Tracking of DNA Cytidine Deamination and Other DNA Modifying Activities. Analytical Chemistry 2018, 90: 11735-11740. PMID: 30256094, PMCID: PMC6410358, DOI: 10.1021/acs.analchem.8b01405.Peer-Reviewed Original ResearchConceptsDNA modificationsCytidine deaminationDNA cytidine deaminationNovel DNA modificationUltra-high performance liquid chromatographyDNA-modifying enzymesImportant DNA modificationImportant biological rolesCytosine methylationHigh-performance liquid chromatographyPerformance liquid chromatographyBiological roleAntiviral defenseCatalytic polypeptideVersatile detectionOligonucleotide substratesDeamination eventsLiquid chromatographyDirect resolutionUracil conversionAnalytical methodEnzymeDeaminationEnzyme inhibitionDNA modifying activity