Structure-Guided Identification of DNMT3B Inhibitors
Newton AS, Faver JC, Micevic G, Muthusamy V, Kudalkar SN, Bertoletti N, Anderson KS, Bosenberg MW, Jorgensen WL. Structure-Guided Identification of DNMT3B Inhibitors. ACS Medicinal Chemistry Letters 2020, 11: 971-976. PMID: 32435413, PMCID: PMC7236258, DOI: 10.1021/acsmedchemlett.0c00011.Peer-Reviewed Original ResearchUltrahigh-performance liquid chromatographyStructure-activity dataGood selectivityExploratory synthesisStructure-Guided IdentificationCrystal structureVirtual screeningAnalytical assaysActive compoundsLiquid chromatographyCompoundsSmall molecule inhibitorsPotent beingHomology modelAdditional inhibitorsAnaloguesFluorogenic assayMolecule inhibitorsSelectivitySynthesisChromatographyDockingStructureHereinIC