Featured Publications
Vitamin D compounds inhibit cancer stem-like cells and induce differentiation in triple negative breast cancer
Shan N, Wahler J, Lee H, Bak M, Gupta S, Maehr H, Suh N. Vitamin D compounds inhibit cancer stem-like cells and induce differentiation in triple negative breast cancer. The Journal Of Steroid Biochemistry And Molecular Biology 2016, 173: 122-129. PMID: 27923595, PMCID: PMC5459680, DOI: 10.1016/j.jsbmb.2016.12.001.Peer-Reviewed Original ResearchConceptsTriple-negative breast cancerVitamin D compoundsCancer stem-like cellsNegative breast cancerBreast cancerStem-like cellsVitamin DCancer stem cellsD compoundsGemini vitamin D analog BXL0124Early breast cancer preventionBreast cancer stem-like cellsBreast cancer stem cell maintenanceBasal-like breast cancerMammosphere cultureBreast cancer preventionCancer cellsCancer stem cell markersPotential preventive agentBreast cancer subtypesBreast cancer cell linesTriple-negative breast cancer cell linesSmooth muscle actinBreast cancer cellsStem-like propertiesBreast cancer stem cells: A review of their characteristics and the agents that affect them
Shan N, Shin Y, Yang G, Furmanski P, Suh N. Breast cancer stem cells: A review of their characteristics and the agents that affect them. Molecular Carcinogenesis 2021, 60: 73-100. PMID: 33428807, PMCID: PMC7855917, DOI: 10.1002/mc.23277.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBreast cancer stem cellsCancer stem cellsBreast cancerCell surface markersCombination therapyTherapeutic effectNew tumorsEffective treatmentXenografted miceCancer developmentSurface markersSerial transplantationCancerPotential agentFurther studiesTranscription factorsTumorsStem cellsBiological effects
2018
Tocopherols inhibit estrogen-induced cancer stemness and OCT4 signaling in breast cancer
Bak M, Furmanski P, Shan N, Lee H, Bao C, Lin Y, Shih W, Yang C, Suh N. Tocopherols inhibit estrogen-induced cancer stemness and OCT4 signaling in breast cancer. Carcinogenesis 2018, 39: 1045-1055. PMID: 29846560, PMCID: PMC6067126, DOI: 10.1093/carcin/bgy071.Peer-Reviewed Original ResearchConceptsBreast cancer stem cellsBreast cancer developmentCancer stem cellsBreast cancerCancer stemnessTrefoil factorEffect of tocopherolCancer developmentSize of tumorspheresBreast cancer stemnessCell invasionStem cell-like propertiesPutative breast cancer stem cellsCell-like propertiesStem cellsStem cell markersAldehyde dehydrogenase activityMammary progenitor cellsEstrogen effectsProgesterone receptorTranscription factor 4Sex-determining region Y-boxInvasion markersRegion Y-boxTissue inhibitor