2024
NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7
Gordon R, Cosgrove H, Marinov A, Gingras S, Tilstra J, Campbell A, Bastacky S, Kashgarian M, Perl A, Nickerson K, Shlomchik M. NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7. JCI Insight 2024, 9: e178563. PMID: 39042716, PMCID: PMC11343599, DOI: 10.1172/jci.insight.178563.Peer-Reviewed Original ResearchSystemic lupus erythematosusB cellsRegulation of TLR7Cell lineagesNADPH oxidaseHematopoietic cell lineagesNF-kB signalingSLE pathologyNOX2 deficiencyMyeloid compartmentMurine lupusLupus nephritisLupus erythematosusTLR7 signalingGlobal deletionInterstitial nephritisImmunomodulatory effectsGlobal knockoutConditional knockoutCYBBNOX2NephritisKnockoutTLR7Chimera approach
2020
B cell-intrinsic TLR9 expression is protective in murine lupus
Tilstra JS, John S, Gordon RA, Leibler C, Kashgarian M, Bastacky S, Nickerson KM, Shlomchik MJ. B cell-intrinsic TLR9 expression is protective in murine lupus. Journal Of Clinical Investigation 2020, 130: 3172-3187. PMID: 32191633, PMCID: PMC7260024, DOI: 10.1172/jci132328.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Systemic lupus erythematosusTLR9 deficiencyTLR9 expressionDendritic cellsB cellsPlasmacytoid dendritic cellsAnti-nucleosome antibodiesLupus erythematosusAutoantibody productionMurine lupusSLE pathogenesisTLR9 signalsReceptor 9Cell type-specific effectsType-specific effectsDisease pathogenesisTherapeutic potentialSelective deletionDiseaseNonredundant roleNephritisLupusPathogenesisDeficiency
1996
The Role of the Kidney Biopsy in the Treatment of Lupus Nephritis
Kashgarian M. The Role of the Kidney Biopsy in the Treatment of Lupus Nephritis. Renal Failure 1996, 18: 765-773. PMID: 8903091, DOI: 10.3109/08860229609047705.Peer-Reviewed Original ResearchConceptsLupus nephritisRenal biopsyLupus erythematosusLong-term outcomesCourse of diseaseWorld Health OrganizationMorphologic modalitiesKidney biopsyRenal diseaseRenal histopathologyClinical outcomesRenal lesionsClinical evaluationHistologic classificationClinical correlationImmune responseIndividual patientsSame patientBiopsy interpretationNephritisPatientsBiopsySemiquantitative assessmentDifferent patientsHealth Organization
1992
Clinical significance of renal biopsy in subacute lupus erythematosus
Kashgarian M. Clinical significance of renal biopsy in subacute lupus erythematosus. Transfusion And Apheresis Science 1992, 13: 135-144. PMID: 10148125, DOI: 10.1016/0955-3886(92)90164-c.Peer-Reviewed Original ResearchConceptsLupus nephritisRenal biopsyLupus erythematosusSubacute lupus erythematosusCourse of illnessLong-term courseWorld Health OrganizationLupus nephropathyMorphologic modalitiesRenal diseaseRenal histopathologyClinical outcomesRenal lesionsClinical evaluationHistologic classificationClinical correlationClinical significanceImmune responseIndividual patientsSame patientBiopsy interpretationPatientsNephritisSemiquantitative assessmentTerm course
1991
Predictors of One Year Outcome in Lupus Nephritis: The Importance of Renal Biopsy
ESDAILE J, FEDERGREEN W, QUINTAL H, SUISSA S, HAYSLETT J, KASHGARIAN M. Predictors of One Year Outcome in Lupus Nephritis: The Importance of Renal Biopsy. QJM 1991, 81: 907-918. DOI: 10.1093/oxfordjournals.qjmed.a068639.Peer-Reviewed Original ResearchLupus nephritisRenal biopsySerum creatinineClinical prediction modelBiopsy variablesPrognosis of lupus nephritisDiffuse proliferative lupus nephritisProliferative lupus nephritisDiffuse proliferative nephritisTime of biopsySubepithelial electron-dense depositsActivity index scoreShort-term prognosisBiopsy informationLaboratory predictorsPlatelet countRenal injuryTubulointerstitial scoresProliferative nephritisUnivariate analysisElectron-dense depositsBiopsyCoexisting illnessesNephritisUrinary protein
1980
The significance of electron dense deposits in mild lupus nephritis.
Domoto D, Kashgarian M, Hayslett J, Adler M, Siegel N. The significance of electron dense deposits in mild lupus nephritis. The Yale Journal Of Biology And Medicine 1980, 53: 317-24. PMID: 7445538, PMCID: PMC2595828.Peer-Reviewed Original ResearchConceptsMild lupusSubendothelial depositsDiffuse proliferative lesionsPercent of patientsDiffuse proliferative glomerulonephritisRate of progressionElectron-dense depositsLupus nephritisSubsequent biopsyPoor prognosisProliferative glomerulonephritisDeteriorating courseMild lesionsProliferative lesionsPatientsProgressionDense depositsLupusLesionsLight microscopyWide variationGlomerulonephritisNephritisBiopsyPrognosis
1971
Mortality trends for chronic nephritis and infections of the kidney A clinical and statistical comparison between mortality in New Haven, Connecticut and the United States, 1950–1960
Du V. Florey C, Kessner D, Kashgarian M, Senter M. Mortality trends for chronic nephritis and infections of the kidney A clinical and statistical comparison between mortality in New Haven, Connecticut and the United States, 1950–1960. Journal Of Clinical Epidemiology 1971, 24: 71-77. PMID: 5568747, DOI: 10.1016/0021-9681(71)90060-9.Peer-Reviewed Original Research