2024
Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study
Puklin L, Irwin M, Sanft T, Ferrucci L, Harrigan M, McGowan C, Cartmel B, Zupa M, Winer E, Deyling M, Ligibel J, Basen-Engquist K, Spiegelman D, Sharifi M. Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study. Supportive Care In Cancer 2024, 32: 590. PMID: 39141176, DOI: 10.1007/s00520-024-08789-5.Peer-Reviewed Original ResearchConceptsPhysical activityLifestyle interventionSelf-reported PA questionnaireSelf-reported diet qualityBreast cancerHealthy Eating Index-2015Stage I-III breast cancerBenefits of PASequential mixed methods studyI-III breast cancerChemotherapy-related symptomsMixed methods studyThematic content analysisBehavioral goalsSense of controlBody mass indexPA questionnaireSemi-structured interviewsMean body mass indexTranscribed verbatimIntervention armTailored educationDiet qualityNutritional behaviorMental benefitsEffects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial
Brown J, Spielmann G, Yang S, Compton S, Jones L, Irwin M, Ligibel J, Meyerhardt J. Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial. Journal Of Cachexia Sarcopenia And Muscle 2024, 15: 1520-1527. PMID: 38887915, PMCID: PMC11294014, DOI: 10.1002/jcsm.13509.Peer-Reviewed Original ResearchAerobic exerciseMyokine concentrationsStage I-III breastColorectal cancer survivorsEffects of exerciseColorectal cancerLinear mixed-effects regression modelsMixed-effects regression modelsCancer survivorsPhysical activityType I error rateExerciseMyokinesPilot studyRegression modelsCancer patientsRandomized trialsHypothesis-generating analysisMultiple comparisonsBreastSkeletal muscleInterleukin-15Clinical outcomesCancerPatientsTrends and predictors of Quality of Life in lung cancer survivors
Bade B, Zhao J, Li F, Tanoue L, Lazowski H, Alfano C, Silvestri G, Irwin M. Trends and predictors of Quality of Life in lung cancer survivors. Lung Cancer 2024, 191: 107793. PMID: 38640687, DOI: 10.1016/j.lungcan.2024.107793.Peer-Reviewed Original ResearchConceptsFunctional Assessment of Cancer Therapy - LungNon-small cell lung cancerHR-QOL scoresLung cancer survivorsHR-QOLAdvanced stage non-small cell lung cancerEarly-stage non-small cell lung cancerStage non-small cell lung cancerQuality of lifeCancer survivorsPhysical activityCell lung cancerEarly-stage diseasePredictors of quality of lifeHealth-related quality of lifeFollow-upHealth-related qualityHealthy weight maintenancePerformance statusAdvanced-stage non-small cell lung cancerLung cancerClinical significanceAssociated with older ageDiagnosed NSCLCTreatment-related side effectsImproving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial
Puklin L, Ferrucci L, Harrigan M, McGowan C, Zupa M, Cartmel B, Li F, Ligibel J, Spiegelman D, Sharifi M, Sanft T, Irwin M. Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial. Cancer 2024, 130: 2440-2452. PMID: 38470431, PMCID: PMC11214600, DOI: 10.1002/cncr.35280.Peer-Reviewed Original ResearchPhysical activityDiet qualityHEI-2015Strength trainingLifestyle behaviorsHealthy Eating Index (HEI)-2015Breast cancerAssociated with baseline fatigueImprove physical activityImprove lifestyle behaviorsHigher HEI-2015Associated with higher oddsExercise interventionUsual careIntervention armIntervention groupBaseline fatigueLifestyle interventionYearlong interventionLower fatigueHigher oddsSecondary analysisLogistic regressionNewly diagnosed patientsStudy arms
2023
Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors
Puklin L, Harrigan M, Cartmel B, Sanft T, Gottlieb L, Zhou B, Ferrucci L, Li F, Spiegelman D, Sharifi M, Irwin M. Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors. Cancers 2023, 15: 4719. PMID: 37835412, PMCID: PMC10571774, DOI: 10.3390/cancers15194719.Peer-Reviewed Original ResearchBreast cancer survivorsCancer survivorsLifestyle interventionPhysical activityQuality of lifeBody weightWaitlist groupDiet qualitySelf-reported body weightWeight lossFavorable weight changeHealthy weight lossBody mass indexHealthy body weightGreater weight lossEvidence-based materialsDiverse healthcare settingsIntervention armMass indexClinical practicePositive behavior changeHealthcare settingsSurvivorsWeight changeInterventionLongitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer
Huang S, Zhan Y, Jeon S, Bruner D, Miller A, Felger J, Wommack E, Saba N, Higgins K, Irwin M, Gary R, Xiao C. Longitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer. Head & Neck 2023, 45: 1952-1966. PMID: 37288586, PMCID: PMC10330673, DOI: 10.1002/hed.27420.Peer-Reviewed Original ResearchConceptsPhysical activityInflammatory markersQuality of lifeLower inflammationNeck cancerTotal QOL scoreHigh physical activityObservational longitudinal studyInactive patientsQOL scoresActive patientsStrength exercisesPatientsInflammationLongitudinal associationsMixed effects modelsSTNFR2Longitudinal studyCancerMarkersAssociationMore researchSubject correlationLow levelsPostradiotherapyTranslating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer
Garcia M, Schadler K, Chandra J, Clinton S, Courneya K, Cruz‐Monserrate Z, Daniel C, Dannenberg A, Demark‐Wahnefried W, Dewhirst M, Fabian C, Hursting S, Irwin M, Iyengar N, McQuade J, Schmitz K, Basen‐Engquist K. Translating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer. CA A Cancer Journal For Clinicians 2023, 73: 425-442. PMID: 36825928, PMCID: PMC11225601, DOI: 10.3322/caac.21773.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsParallel studyHealthy survivorshipCancer outcomesDietary intakePhysical activityAnimal modelsClinical observationsAnimal studiesBody compositionCancer developmentPractice changeCancerPopulation studiesCancer researchEnergy balance researchEnergy balancePatientsSubstantial benefitsClinicStudyIntake
2022
Adherence to the American Cancer Society Guidelines on nutrition and physical activity for cancer prevention and obesity‐related cancer risk and mortality in Black and Latina Women's Health Initiative participants
Pichardo MS, Esserman D, Ferrucci LM, Molina Y, Chlebowski RT, Pan K, Garcia DO, Lane DS, Shadyab AH, Lopez‐Pentecost M, Luo J, Kato I, Springfield S, Rosal MC, Bea JW, Feliciano E, Qi L, Nassir R, Snetselaar L, Manson J, Bird C, Irwin ML. Adherence to the American Cancer Society Guidelines on nutrition and physical activity for cancer prevention and obesity‐related cancer risk and mortality in Black and Latina Women's Health Initiative participants. Cancer 2022, 128: 3630-3640. PMID: 35996861, DOI: 10.1002/cncr.34428.Peer-Reviewed Original ResearchConceptsAmerican Cancer Society guidelinesObesity-related cancersWomen's Health InitiativeGuideline adherenceSociety guidelinesHealth initiativesPhysical activityLower riskEffect modificationCancer preventionObesity-related cancer incidenceObesity-related cancer riskWomen's Health Initiative participantsLatina womenPotential effect modificationPublic health interventionsNeighborhood socioeconomic statusCause deathCause mortalityLifestyle guidelinesPostmenopausal womenCancer incidenceLower incidenceACS guidelinesHigh adherenceA competing risk analysis of adherence to the American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention and obesity‐related cancer risk in Hispanic/Latino adults in the NIH‐AARP Diet and Health Study
Pichardo MS, Irwin ML, Esserman D, Molina Y, Ferrucci LM. A competing risk analysis of adherence to the American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention and obesity‐related cancer risk in Hispanic/Latino adults in the NIH‐AARP Diet and Health Study. International Journal Of Cancer 2022, 151: 1902-1912. PMID: 35802472, PMCID: PMC9588580, DOI: 10.1002/ijc.34200.Peer-Reviewed Original ResearchConceptsHispanic/Latino adultsObesity-related cancersUS Hispanic/Latino adultsAmerican Cancer Society guidelinesNIH-AARP DietHealthy lifestyle behaviorsGuideline adherenceLatino adultsSociety guidelinesLifestyle behaviorsCancer preventionPhysical activityCancer riskHealth StudyObesity-related cancer riskPublic health effortsHypothesized inverse associationMagnitude of riskAdherence categoriesInverse associationCancer incidenceACS guidelinesHigh adherenceCumulative riskHealth effortsRandomized trial of diet and exercise on chemotherapy completion in women with breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) study.
Sanft T, Harrigan M, Cartmel B, Li F, Zupa M, McGowan C, Ferrucci L, Puklin L, Nguyen T, Tanasijevic A, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf M, Chagpar A, Silber A, Ligibel J, Irwin M. Randomized trial of diet and exercise on chemotherapy completion in women with breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) study. Journal Of Clinical Oncology 2022, 40: 12007-12007. DOI: 10.1200/jco.2022.40.16_suppl.12007.Peer-Reviewed Original ResearchRelative dose intensityHigh relative dose intensityBreast cancerDose-response effectPhysical activityPA interventionsNeoadjuvant chemotherapyChemotherapy completionDiet qualityStage I breast cancerEndocrine therapy adherenceTrial of dietDifferent chemotherapy regimensI breast cancerBody mass indexPatient-reported outcomesHealthy Eating IndexBetter diet qualityHigh physical activityMore physical activityElectronic medical recordsChi-square testUC participantsChemotherapy regimensSecondary endpointsCardiometabolic risk factors, physical activity, and postmenopausal breast cancer mortality: results from the Women’s Health Initiative
Dieli-Conwright CM, Nelson RA, Simon MS, Irwin ML, Neuhouser ML, Reding KW, Crane TE, Manson JE, Nassir R, Shadyab AH, LaMonte M, Qi L, Thomson CA, Kroenke CH, Pan K, Chlebowski RT, Mortimer J. Cardiometabolic risk factors, physical activity, and postmenopausal breast cancer mortality: results from the Women’s Health Initiative. BMC Women's Health 2022, 22: 32. PMID: 35120497, PMCID: PMC8817588, DOI: 10.1186/s12905-022-01614-3.Peer-Reviewed Original ResearchConceptsBreast cancer-specific mortalityCancer-specific mortalityWomen's Health Initiative participantsEarly-stage breast cancerCardiometabolic risk factorsBreast cancer mortalityPhysical activity levelsRisk factor numberPhysical activityBreast cancerRisk factorsCancer mortalityHigher breast cancer-specific mortalityLower breast cancer-specific mortalityInitiative participantsHealth initiativesNational Death Index queryProportional hazards regression modelsHigher physical activity levelsCancer diagnosisMetabolic syndrome componentsBaseline physical activityHigh waist circumferenceMedical record reviewCause mortality risk
2021
The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention
Delahanty LM, Wadden TA, Goodwin PJ, Alfano CM, Thomson CA, Irwin ML, Neuhouser ML, Crane TE, Frank E, Spears PA, Gillis BP, Hershman DL, Paskett ED, Hopkins J, Bernstein V, Stearns V, White J, Hudis C, Winer EP, Carey L, Partridge AH, Ligibel JA. The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention. Obesity 2021, 30: 28-38. PMID: 34932888, PMCID: PMC9186690, DOI: 10.1002/oby.23287.Peer-Reviewed Original ResearchConceptsWeight loss interventionWeight loss trialLifestyle interventionHealth education materialsWeight lossLoss trialPhysical activityInvasive disease-free survivalDisease-free survivalBreast cancer patientsBreast cancer diagnosisCare of thousandsEducation materialsBaseline weightCancer outcomesCancer patientsHealth coachesCancer recurrenceBreast cancerCaloric restrictionStage IITrialsCancer diagnosisInterventionWomenPrediagnosis and postdiagnosis leisure time physical activity and survival following diagnosis with ovarian cancer
Wang T, Townsend MK, Eliassen AH, Terry KL, Song M, Irwin ML, Tworoger SS. Prediagnosis and postdiagnosis leisure time physical activity and survival following diagnosis with ovarian cancer. International Journal Of Cancer 2021, 149: 1067-1075. PMID: 33963766, PMCID: PMC8282739, DOI: 10.1002/ijc.33676.Peer-Reviewed Original ResearchConceptsOvarian cancer-specific mortalityCancer-specific mortalityNurses' Health StudyPhysical activityHazard ratioOvarian cancerHealth StudyWeek 1MET-hours/weekLow-grade serous tumorsLeisure-time physical activityPostdiagnosis physical activityRisk of deathEpithelial ovarian cancerOvarian cancer survivalConfidence intervalsTime physical activityOvarian cancer diagnosisBetter prognosisSerous tumorsCancer survivalInverse associationLarge cohortDiagnosisCancer diagnosis“Randomized trial of physical activity on quality of life and lung cancer biomarkers in patients with advanced stage lung cancer: a pilot study”
Bade BC, Gan G, Li F, Lu L, Tanoue L, Silvestri GA, Irwin ML. “Randomized trial of physical activity on quality of life and lung cancer biomarkers in patients with advanced stage lung cancer: a pilot study”. BMC Cancer 2021, 21: 352. PMID: 33794808, PMCID: PMC8015735, DOI: 10.1186/s12885-021-08084-0.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerAdvanced-stage lung cancerStage lung cancerUsual carePhysical activityIntervention groupQuality of lifeLung cancerEligible patientsStage III/IV non-small cell lung cancerLow baseline physical activityHome-based physical activityAdvanced stage diseaseSoluble PD-1Stage IV adenocarcinomaBaseline physical activityMinority of patientsCell lung cancerPatient-reported outcomesEffects of exerciseRole functioning domainsLung cancer biologyAspects of QoL.Mobile health interventionsCancer biomarkersRandomized trial of exercise on depressive symptomatology and brain derived neurotrophic factor (BDNF) in ovarian cancer survivors: The Women's Activity and Lifestyle Study in Connecticut (WALC)
Cartmel B, Hughes M, Ercolano EA, Gottlieb L, Li F, Zhou Y, Harrigan M, Ligibel JA, von Gruenigen VE, Gogoi R, Schwartz PE, Risch HA, Lu L, Irwin ML. Randomized trial of exercise on depressive symptomatology and brain derived neurotrophic factor (BDNF) in ovarian cancer survivors: The Women's Activity and Lifestyle Study in Connecticut (WALC). Gynecologic Oncology 2021, 161: 587-594. PMID: 33773809, PMCID: PMC8085084, DOI: 10.1016/j.ygyno.2021.02.036.Peer-Reviewed Original ResearchConceptsOvarian cancer survivorsCES-D scoresCancer survivorsOvarian cancerDepressive symptomatologyAC armStage III/IV ovarian cancerBaseline CES-D scoreTrial of exerciseEpidemiologic Studies Depression ScaleOvarian cancer patientsEffects of exerciseSix-month changesPrevalent mental disordersLower depressive symptomsExercise armSerum BrainNeurotrophin factorRandomized trialsNeurotrophic factorCancer patientsLifestyle StudyDepression ScalePhysical activityDepressive symptomsA randomized trial of physical activity for cognitive functioning in breast cancer survivors: Rationale and study design of I Can! Improving Cognition After Cancer
Hartman SJ, Weiner LS, Natarajan L, Sears DD, Palmer BW, Parker B, Ahles T, Irwin ML, Au K. A randomized trial of physical activity for cognitive functioning in breast cancer survivors: Rationale and study design of I Can! Improving Cognition After Cancer. Contemporary Clinical Trials 2021, 102: 106289. PMID: 33503496, PMCID: PMC8009833, DOI: 10.1016/j.cct.2021.106289.Peer-Reviewed Original ResearchConceptsSelf-reported cognitionBreast cancer survivorsProcessing speedPhysical activity interventionsCancer survivorsPost-treatment breast cancer survivorsMaintenance of effectsPhysical activityActivity interventionsPsychological mediatorsCognitive functioningCognition outcomesCognitive difficultiesCognitive changesCognitionIntervention literatureCandidate biological mechanismDaily functioningPromising interventionCognitive impairmentIntervention effectsPhysical activity intervention trialNon-cancer populationImpact of exerciseQuality of life
2020
Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial
Brown JC, Zhang S, Ligibel JA, Irwin ML, Jones LW, Campbell N, Pollak MN, Sorrentino A, Cartmel B, Harrigan M, Tolaney SM, Winer EP, Ng K, Abrams TA, Sanft T, Douglas PS, Hu FB, Fuchs CS, Meyerhardt JA. Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial. Cancer Prevention Research 2020, 13: 1055-1062. PMID: 32859615, PMCID: PMC7718298, DOI: 10.1158/1940-6207.capr-20-0188.Peer-Reviewed Original ResearchConceptsHs-CRPColorectal cancerPhysical activityHigh-sensitivity C-reactive proteinLow baseline physical activitySurvivors of breastTrial product estimandBaseline physical activityBiomarkers of inflammationC-reactive proteinMeasures of inflammationImproved clinical outcomesEffects of exerciseType 2 diabetesCombination of exerciseStandard therapyClinical outcomesCancer recurrenceObservational studyTreatment groupsInflammation outcomesMetforminIL6Factorial trialInflammationEnergetics
Ferrucci L, Irwin M. Energetics. 2020, 303-320. DOI: 10.1007/978-3-030-42011-6_15.Peer-Reviewed Original ResearchWeight loss interventionCancer riskLoss interventionCancer outcomesRisk factorsReduced cancer riskIndependent risk factorEnergy balance interventionsDifferent cancer sitesDiet interventionPhysical inactivityDifferent cancer typesSurrogate markerCancer sitesBalance interventionsPhysical activityNew therapiesPoor dietObesityVaried age groupsAge groupsCancer typesCancer developmentMortalityWeight loss
2016
Effects of Physical Activity on DNA Methylation and Associations with Breast Cancer
Yu H, Irwin M. Effects of Physical Activity on DNA Methylation and Associations with Breast Cancer. Energy Balance And Cancer 2016, 11: 251-264. DOI: 10.1007/978-3-319-41610-6_11.Peer-Reviewed Original ResearchDNA methylationTumor suppressor genePhysical activityEpigenetic regulationSuppressor geneCancer riskGenome-wide methylationBetter patient survivalBreast cancer patientsPro-inflammatory cytokinesBreast cancer riskSex steroid hormonesLower cancer riskMitogenic growth factorsEntire genomeMolecular mechanismsInsulin resistancePatient survivalCancer patientsMethylationMore profound impactsCancer preventionBreast cancerDisease outcomeHealthy individuals
2014
Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative
Zhou Y, Chlebowski R, LaMonte MJ, Bea JW, Qi L, Wallace R, Lavasani S, Walsh BW, Anderson G, Vitolins M, Sarto G, Irwin ML. Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative. Gynecologic Oncology 2014, 133: 4-10. PMID: 24680584, PMCID: PMC4064800, DOI: 10.1016/j.ygyno.2014.01.033.Peer-Reviewed Original ResearchConceptsWomen's Health InitiativeBody mass indexVigorous-intensity physical activityOvarian cancerPhysical activityHealth initiativesLower riskCause mortalityMass indexSelf-reported physical activityOvarian cancer mortalityModifiable lifestyle factorsProportional hazards regressionPrimary ovarian cancerOvarian cancer diagnosisPostmenopausal womenBaseline visitHazards regressionLifestyle factorsCancer mortalityMortality endpointsSurvival rateMortalityCancerCancer diagnosis