2024
Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2024, 134: e180583. PMID: 38488004, PMCID: PMC10940080, DOI: 10.1172/jci180583.Peer-Reviewed Original ResearchToxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024
Krishnan N, Moledina D, Perazella M. Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024. American Journal Of Kidney Diseases 2024, 83: 659-676. PMID: 38243994, DOI: 10.1053/j.ajkd.2023.09.017.Peer-Reviewed Original ResearchRenal injurySeverity of renal injuryToxic nephropathyTubulointerstitial renal injuryIrreversible renal injuryToxin-induced renal injuryImmune response genesNephrotoxic riskClinical presentationTubulointerstitial injuryRenal functionClinical manifestationsPatient characteristicsTubular secretionGlomerular filtrationComorbid conditionsMetabolic handlingDrug metabolismExcretory pathwayInjuryTransport defectAdverse effectsTubulointerstitiumNephropathyExogenous toxins
2023
Hiding in Plain Sight: Catastrophic Diethylene Glycol Poisoning in Children
Perazella M. Hiding in Plain Sight: Catastrophic Diethylene Glycol Poisoning in Children. Kidney360 2023, 4: 1534-1535. PMID: 37831818, PMCID: PMC10695641, DOI: 10.34067/kid.0000000000000269.Peer-Reviewed Original ResearchA Patient with an Unusual Cause of AKI and Scrotal Swelling
Gomez D, Perazella M. A Patient with an Unusual Cause of AKI and Scrotal Swelling. Kidney360 2023, 4: 1188-1189. PMID: 37651667, PMCID: PMC10484347, DOI: 10.34067/kid.0000000000000125.Peer-Reviewed Original ResearchIdentification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2023, 133: e168950. PMID: 37395276, PMCID: PMC10313360, DOI: 10.1172/jci168950.Peer-Reviewed Original ResearchConceptsUrinary CXCL9External validation cohortValidation cohortControl groupAIN diagnosisDiscovery cohortKidney tissueDiagnostic biomarkersAcute interstitial nephritisCXCL9 mRNA expressionAcute kidney injuryBiopsy-confirmed diagnosisAvailable clinical testsNational InstituteKidney injuryTubulointerstitial nephritisInterstitial nephritisKidney biopsyHistological confirmationHistological diagnosisTreatment optionsLymphocyte chemotaxisCXCL9MRNA expression differencesPatientsContrast-Induced Acute Kidney Injury and Cardiovascular Imaging: Danger or Distraction?
Davenport M, Perazella M, Nallamothu B. Contrast-Induced Acute Kidney Injury and Cardiovascular Imaging: Danger or Distraction? Circulation 2023, 147: 847-849. PMID: 36913495, DOI: 10.1161/circulationaha.122.062783.Peer-Reviewed Original ResearchAcquired Disorders of Hypomagnesemia
Rosner M, Ha N, Palmer B, Perazella M. Acquired Disorders of Hypomagnesemia. Mayo Clinic Proceedings 2023, 98: 581-596. PMID: 36872194, DOI: 10.1016/j.mayocp.2022.12.002.Peer-Reviewed Original ResearchConceptsReduced glomerular filtration rateBody storesBody magnesium storesGlomerular filtration rateSerum magnesium levelsTotal body storesDevelopment of symptomsIntravenous replacementOrgan dysfunctionMagnesium disordersRenal lossMagnesium replacementFiltration rateSevere casesMagnesium storesHypomagnesemiaClinical experienceClinical practiceMagnesium levelsAcquired disordersAmphotericin BMagnesium handlingOptimal managementMedicationsLaboratory assessment
2022
Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity
Qian L, Menez S, Hu D, Weinstein J, Melchinger H, Thiessen-Philbrook H, Luciano R, Turner J, Perazella M, Villalobos C, Shaw M, Wilson F, Parikh C, Moledina D. Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity. Kidney360 2022, 4: 98-101. PMID: 36700910, PMCID: PMC10101611, DOI: 10.34067/kid.0006602022.Peer-Reviewed Original ResearchImmune checkpoints inhibitors and its link to acute kidney injury and renal prognosis
Kanbay M, Yildiz AB, Siriopol D, Vehbi S, Hasbal NB, Kesgin YE, Celayir M, Selcukbiricik F, Covic A, Perazella MA. Immune checkpoints inhibitors and its link to acute kidney injury and renal prognosis. International Urology And Nephrology 2022, 55: 1025-1032. PMID: 36282399, DOI: 10.1007/s11255-022-03395-y.Peer-Reviewed Original ResearchConceptsAcute kidney injuryImmune checkpoint inhibitorsSolid organ malignanciesCheckpoint inhibitorsKidney injuryOrgan malignanciesNephrotoxic agentsSingle-center retrospective cohort studyType of ICIBaseline serum creatinine levelAcute interstitial nephritisLocation of malignancyRetrospective cohort studySerum creatinine levelsKidney function recoveryRenal replacement therapyUrinary tract obstructionRisk of mortalityICPI treatmentRenal prognosisTract obstructionCohort studyCreatinine levelsFive patientsInterstitial nephritisVancomycin Should Be Considered a Nephrotoxic Antimicrobial Agent: COMMENTARY
Perazella MA. Vancomycin Should Be Considered a Nephrotoxic Antimicrobial Agent: COMMENTARY. Kidney360 2022, 3: 1491-1493. PMID: 36250736, PMCID: PMC9528384, DOI: 10.34067/kid.0008112021.Peer-Reviewed Original ResearchDiagnosis and management of immune checkpoint inhibitor-associated acute kidney injury
Sprangers B, Leaf DE, Porta C, Soler MJ, Perazella MA. Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury. Nature Reviews Nephrology 2022, 18: 794-805. PMID: 36168055, DOI: 10.1038/s41581-022-00630-8.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsAcute kidney injuryKidney injuryKidney biopsyAcute tubulo-interstitial nephritisImmune-related adverse eventsConcomitant anticancer therapyTubulo-interstitial nephritisEffector T cellsEvaluation of patientsLoss of toleranceCheckpoint inhibitorsPartial remissionPermanent discontinuationAdverse eventsMost patientsAppropriate treatmentEarly initiationT cellsClinical practiceFavorable responsePatientsAccurate diagnosisCancer treatmentAnticancer therapyThe association between acute kidney injury and outcomes in cancer patients receiving immune checkpoint inhibitor therapy: a systematic review and meta-analysis
Kanbay M, Copur S, Siriopol D, Yildiz A, Berkkan M, Popa R, Hasbal N, Ortiz A, Perazella M. The association between acute kidney injury and outcomes in cancer patients receiving immune checkpoint inhibitor therapy: a systematic review and meta-analysis. Clinical Kidney Journal 2022, 16: 817-826. PMID: 37151409, PMCID: PMC10157786, DOI: 10.1093/ckj/sfac194.Peer-Reviewed Original ResearchAcute kidney injuryImmune checkpoint inhibitorsEffect of AKICheckpoint inhibitorsCancer patientsKidney injuryDevelopment of AKISystematic reviewImmune checkpoint inhibitor therapySevere acute kidney injuryPersistent kidney dysfunctionSevere AKI patientsCheckpoint inhibitor therapyRisk of deathNon-randomized studiesCochrane Library databasesRisk of mortalityNovel therapeutic approachesWeb of ScienceAKI patientsICPI treatmentCause mortalityInhibitor therapyKidney dysfunctionMortality outcomesDrug-Induced Acute Kidney Injury
Perazella MA, Rosner MH. Drug-Induced Acute Kidney Injury. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1220-1233. PMID: 35273009, PMCID: PMC9435983, DOI: 10.2215/cjn.11290821.Peer-Reviewed Original ResearchConceptsKidney injuryTubular injuryDrug-induced acute kidney injuryT cell-mediated immune responsesDrug-related kidney injuryCell-mediated immune responsesAcute interstitial nephritisDirect tubular injuryTreatment of AKIAcute kidney injuryAcute tubular injuryIntensive care unitInduction of inflammationAKI riskIntratubular obstructionTubulointerstitial injuryInterstitial nephritisCare unitInflammation leadInjury resultsCommon causeImmune responseHospital wardsProximal tubulesAKIImproving Cancer Care for Patients With CKD: The Need for Changes in Clinical Trials
Sprangers B, Perazella MA, Lichtman SM, Rosner MH, Jhaveri KD. Improving Cancer Care for Patients With CKD: The Need for Changes in Clinical Trials. Kidney International Reports 2022, 7: 1939-1950. PMID: 36090489, PMCID: PMC9458993, DOI: 10.1016/j.ekir.2022.06.005.Peer-Reviewed Original ResearchChronic kidney diseaseEnd-stage kidney diseaseSevere kidney dysfunctionKidney diseaseKidney dysfunctionAdvanced kidney diseaseOptimal clinical careCancer drug trialsNumber of patientsNarrow therapeutic indexInitial clinical studiesKidney replacement treatmentPreregistration studiesKidney functionCancer careReplacement treatmentCancer trialsClinical trialsEffective dosingClinical studiesTreatment decisionsDrug trialsBeneficial drugsClinical carePatientsUrine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy
Tran AC, Melchinger H, Weinstein J, Shaw M, Kent C, Perazella MA, Wilson FP, Parikh CR, Moledina DG. Urine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy. Practical Laboratory Medicine 2022, 30: e00271. PMID: 35465621, PMCID: PMC9018443, DOI: 10.1016/j.plabm.2022.e00271.Peer-Reviewed Original ResearchTubulointerstitial diseaseKidney biopsyGlomerular diseaseUrine albuminHistological diagnosisUrine uromodulinUrine testsHigher urine albuminUrine sediment microscopyCohort of participantsDipstick hematuriaTubular injuryAppropriate patientsUrine testingMultivariable modelHigher oddsBiopsyClinical decisionSediment microscopyDiseasePatientsHealth biomarkersUrine samplesDiagnosisCohortAcute Interstitial Nephritis and Crystalline Nephropathies
Moledina D, Herlitz L, Perazella M. Acute Interstitial Nephritis and Crystalline Nephropathies. Nephrology Self-Assessment Program 2022, 21: 50-70. DOI: 10.1681/nsap.2022.21.1.5.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDrug-Induced Osmotic Nephropathy: Add SGLT2-Inhibitors to the List?
Perazella MA, Juncos LA. Drug-Induced Osmotic Nephropathy: Add SGLT2-Inhibitors to the List? Kidney360 2022, 3: 550-553. PMID: 35582186, PMCID: PMC9034826, DOI: 10.34067/kid.0007882021.Peer-Reviewed Original ResearchMortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy
Baker ML, Yamamoto Y, Perazella MA, Dizman N, Shirali AC, Hafez N, Weinstein J, Simonov M, Testani JM, Kluger HM, Cantley LG, Parikh CR, Wilson FP, Moledina DG. Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy. Journal For ImmunoTherapy Of Cancer 2022, 10: e004421. PMID: 35354588, PMCID: PMC8968986, DOI: 10.1136/jitc-2021-004421.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisAcute kidney injuryImmune checkpoint inhibitor therapyCheckpoint inhibitor therapyICI therapyKidney injuryInhibitor therapyInterstitial nephritisTime-varying Cox proportional hazards modelsHigher peak serum creatinineSevere acute kidney injuryCancer typesCox proportional hazards modelAssociations of biopsyBaseline laboratory valuesObservational cohort studyPeak serum creatinineFavorable treatment responseProportional hazards modelAKI patientsTherapy initiationCohort studySerum creatinineUnivariable analysisImmune activationImaging Modalities for Acute Tubulointerstitial Nephritis
Baker M, Perazella M. Imaging Modalities for Acute Tubulointerstitial Nephritis. 2022, 257-266. DOI: 10.1007/978-3-030-93438-5_20.ChaptersAcute tubulointerstitial nephritisTubulointerstitial nephritisAcute kidney injury diagnosisNonspecific constitutional symptomsChronic kidney diseaseImaging modalitiesCurrent imaging modalitiesEmission Tomography ImagingPositron emission tomography (PET) imagingNon-invasive diagnosisConstitutional symptomsFlank painMost patientsKidney diseaseKidney failureCase reportInjury diagnosisRadiographic cluesClinical dataCommon causeGallium uptakeCharacteristic signsSymptomsDiagnosisTomography imagingSevere AKI in a Patient on Multiple Antimicrobial Agents for Leg Infection
Rehan A, Moeckel GW, Perazella MA. Severe AKI in a Patient on Multiple Antimicrobial Agents for Leg Infection. Kidney360 2022, 3: 405-406. PMID: 35373119, PMCID: PMC8967631, DOI: 10.34067/kid.0006102021.Peer-Reviewed Original Research