2023
Contrast-Induced Acute Kidney Injury and Cardiovascular Imaging: Danger or Distraction?
Davenport M, Perazella M, Nallamothu B. Contrast-Induced Acute Kidney Injury and Cardiovascular Imaging: Danger or Distraction? Circulation 2023, 147: 847-849. PMID: 36913495, DOI: 10.1161/circulationaha.122.062783.Peer-Reviewed Original Research
2022
Immune checkpoints inhibitors and its link to acute kidney injury and renal prognosis
Kanbay M, Yildiz AB, Siriopol D, Vehbi S, Hasbal NB, Kesgin YE, Celayir M, Selcukbiricik F, Covic A, Perazella MA. Immune checkpoints inhibitors and its link to acute kidney injury and renal prognosis. International Urology And Nephrology 2022, 55: 1025-1032. PMID: 36282399, DOI: 10.1007/s11255-022-03395-y.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryHumansImmune Checkpoint InhibitorsKidneyNeoplasmsPrognosisRetrospective StudiesRisk FactorsConceptsAcute kidney injuryImmune checkpoint inhibitorsSolid organ malignanciesCheckpoint inhibitorsKidney injuryOrgan malignanciesNephrotoxic agentsSingle-center retrospective cohort studyType of ICIBaseline serum creatinine levelAcute interstitial nephritisLocation of malignancyRetrospective cohort studySerum creatinine levelsKidney function recoveryRenal replacement therapyUrinary tract obstructionRisk of mortalityICPI treatmentRenal prognosisTract obstructionCohort studyCreatinine levelsFive patientsInterstitial nephritis
2020
Use of Intravenous Iodinated Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation
Davenport MS, Perazella MA, Yee J, Dillman JR, Fine D, McDonald RJ, Rodby RA, Wang CL, Weinreb JC. Use of Intravenous Iodinated Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation. Radiology 2020, 294: 192094. PMID: 31961246, DOI: 10.1148/radiol.2019192094.Peer-Reviewed Original ResearchConceptsAcute kidney injuryGlomerular filtration rateContrast mediumKidney diseaseFiltration rateContrast-associated acute kidney injuryContrast-induced acute kidney injuryIntravenous normal salineReduced kidney functionSevere kidney diseaseNational Kidney FoundationIodinated Contrast MediaHigh-risk circumstancesSimultaneous joint publicationCI-AKIKidney injuryMaintenance dialysisKidney functionOrdering clinicianNormal salineConsensus statementKidney FoundationTreatment responseAmerican CollegePatients
2019
Acute Kidney Injury and CKD Associated with Hematopoietic Stem Cell Transplantation
Renaghan AD, Jaimes EA, Malyszko J, Perazella MA, Sprangers B, Rosner MH. Acute Kidney Injury and CKD Associated with Hematopoietic Stem Cell Transplantation. Clinical Journal Of The American Society Of Nephrology 2019, 15: 289-297. PMID: 31836598, PMCID: PMC7015091, DOI: 10.2215/cjn.08580719.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationStem cell transplantationCell transplantationKidney injuryHepatic sinusoidal obstruction syndromeAcute kidney injurySinusoidal obstruction syndromeCongenital immune deficiencyDevelopment of CKDType of transplantNonmalignant hematologic disordersStem cell transplantLife-saving therapySickle cell diseaseHigh mortality rateAcute dialysisNephrotoxic medicationsNonrelapse mortalityConditioning regimenHost diseaseInfusion syndromeObstruction syndromeThrombotic microangiopathyTransplant recipientsPatient characteristics
2015
Drug-Induced Glomerular Disease: Direct Cellular Injury
Markowitz GS, Bomback AS, Perazella MA. Drug-Induced Glomerular Disease: Direct Cellular Injury. Clinical Journal Of The American Society Of Nephrology 2015, 10: 1291-1299. PMID: 25862776, PMCID: PMC4491280, DOI: 10.2215/cjn.00860115.Peer-Reviewed Original ResearchConceptsGlomerular diseaseCell injuryGlomerular lesionsNonsteroidal anti-inflammatory drugsAcute interstitial nephritisDrug-induced etiologyPotential of medicationsRenal function recoveryAcute tubular necrosisEndothelial cell injuryMesangial cell injuryEpithelial cell injuryAnti-inflammatory drugsDirect cellular injuryRapid discontinuationKidney injuryTubular necrosisAntiplatelet agentsInterstitial nephritisTubulointerstitial compartmentFunction recoveryIatrogenic formCellular injuryAntiangiogenesis drugsInjury
2009
Acute phosphate nephropathy
Markowitz GS, Perazella MA. Acute phosphate nephropathy. Kidney International 2009, 76: 1027-1034. PMID: 19675530, DOI: 10.1038/ki.2009.308.Peer-Reviewed Original ResearchConceptsAcute phosphate nephropathyAcute kidney injuryChronic kidney diseasePhosphate nephropathySubsequent chronic renal failureChronic tubular injuryAngiotensin receptor blockersChronic renal failureHigh-risk patientsRenal biopsy findingsClinical-pathological entityAggressive hydrationKidney injuryReceptor blockersBiopsy findingsRenal failureTubular injuryKidney diseasePathological entityRisk factorsFemale genderDistal tubulesEpidemiologic studiesDistal nephronEnzyme inhibitorsRenal Vulnerability to Drug Toxicity
Perazella MA. Renal Vulnerability to Drug Toxicity. Clinical Journal Of The American Society Of Nephrology 2009, 4: 1275-1283. PMID: 19520747, DOI: 10.2215/cjn.02050309.Peer-Reviewed Original ResearchConceptsDrug-induced kidney diseaseKidney diseaseRenal vulnerabilityRisk factorsAcute kidney injuryChronic kidney diseaseDrug-related factorsProteinuric renal diseaseKidney injuryRenal complicationsRenal injuryRenal diseaseNephrotoxic effectsRenal syndromeDrug toxicityDiseaseInjuryKidneyDrugsFactor categoriesToxinComplicationsPatientsFactorsTubulopathy
2004
Intravenous Iron and the Risk of Infection in End‐Stage Renal Disease Patients
Perazella M, Brewster U, Perazella M. Intravenous Iron and the Risk of Infection in End‐Stage Renal Disease Patients. Seminars In Dialysis 2004, 17: 57-60. PMID: 14717813, DOI: 10.1111/j.1525-139x.2004.17115.x.BooksConceptsInnate immune responseRisk of infectionIntravenous ironEnd-stage renal disease patientsHost innate immune responseRenal disease patientsIron-deficient patientsAdministration of ironOral ironIron therapyMost patientsHemodialysis patientsActive infectionDisease patientsIron preparationsIron overloadAllergic reactionsClinical studiesImmune responsePatientsBacterial infectionsIron deficiencyInfectionRiskBacterial growth
2001
Pharmacologic options available to treat symptomatic intradialytic hypotension
Perazella M. Pharmacologic options available to treat symptomatic intradialytic hypotension. American Journal Of Kidney Diseases 2001, 38: s26-s36. PMID: 11602458, DOI: 10.1053/ajkd.2001.28092.Peer-Reviewed Original ResearchConceptsSymptomatic intradialytic hypotensionIntradialytic hypotensionHigh-risk patientsLower blood pressurePharmacologic optionsPharmacologic therapyBlood pressurePatient factorsAvailable therapiesPharmacologic interventionsHypotensionTherapyTreatmentInitial approachMidodrineNephrologistsPatientsSertraline
2000
Trimethoprim-Induced Hyperkalaemia
Perazella M. Trimethoprim-Induced Hyperkalaemia. Drug Safety 2000, 22: 227-236. PMID: 10738846, DOI: 10.2165/00002018-200022030-00006.Peer-Reviewed Original ResearchConceptsRenal potassium excretionPotassium excretionHigh urinary flow ratesPotassium homeostasisManagement of hyperkalaemiaGlomerular filtration ratePotassium-sparing diuretic amilorideUrinary flow rateRecognition of patientsDistal nephron cellsTrimethoprim therapyRenal impairmentCommon complicationLoop diureticsEpithelial sodium channelIntravenous fluidsVolume repletionAdverse reactionsFiltration rateRisk factorsStandard dosageAntikaliuretic effectHyperkalaemiaIsotonic fluidsDistal nephron
1997
Intradialytic hypotension: Is midodrine beneficial in symptomatic hemodialysis patients?
Cruz D, Mahnensmith R, Perazella M. Intradialytic hypotension: Is midodrine beneficial in symptomatic hemodialysis patients? American Journal Of Kidney Diseases 1997, 30: 772-779. PMID: 9398120, DOI: 10.1016/s0272-6386(97)90081-0.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdrenergic alpha-AgonistsAgedAged, 80 and overBlood PressureDiastoleDizzinessFatigueFemaleFollow-Up StudiesHumansHypotensionKidney Failure, ChronicLongitudinal StudiesMaleMiddle AgedMidodrineMuscle CrampMuscle WeaknessParesthesiaProspective StudiesPulseRenal DialysisRisk FactorsSafetyScalpSystoleConceptsDiastolic blood pressureSystolic blood pressureBlood pressureMidodrine therapyArterial pressureHemodialysis patientsIntradialytic hypotensionPulse rateEnd-stage renal disease patientsIntradialytic systolic blood pressureEfficacy of midodrineSymptomatic hemodialysis patientsNeurogenic orthostatic hypotensionMean arterial pressureRenal disease patientsAdequate patient numbersBlood pressure measurementsAlpha-adrenergic agonist activityConsecutive dialysis sessionsAutonomic dysfunctionDialysis hypotensionOral agentsOrthostatic hypotensionSymptomatic hypotensionProspective trialHyperkalemia in the Elderly
Perazella M, Mahnensmith R. Hyperkalemia in the Elderly. Journal Of General Internal Medicine 1997, 12: 646-656. PMID: 9346463, PMCID: PMC1497179, DOI: 10.1046/j.1525-1497.1997.07128.x.Peer-Reviewed Original ResearchConceptsDevelopment of hyperkalemiaPotassium-altering medicationsAppropriate managementPrevention of hyperkalemiaHigh-risk medicationsManagement of hyperkalemiaCellular potassium uptakePlasma potassium concentrationPertinent review articlesCardiac complicationsElderly patientsPotassium handlingRenal functionSevere hyperkalemiaCertain medicationsElectrolyte disordersGeriatric patientsClinical manifestationsElderly subjectsMEDLINE searchHyperkalemiaMedicationsDisease processRenal disposalPotassium levels
1996
Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose.
Perazella M, Mahnensmith R. Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose. Clinical Nephrology 1996, 46: 187-92. PMID: 8879854.Peer-Reviewed Original ResearchConceptsTrimethoprim-sulfamethoxazole therapyStandard doseDevelopment of hyperkalemiaTrimethoprim-sulfamethoxazole useMild renal insufficiencyProspective surveillance studyPotassium-sparing diuretic amilorideRenal potassium excretionPneumocystis carinii pneumoniaLethal adverse reactionHandful of casesRenal insufficiencyElderly patientsPotassium excretionSevere hyperkalemiaImportant complicationAIDS patientsCarinii pneumoniaTrimethoprim-sulfamethoxazoleAdverse reactionsInduced hyperkalemiaPotassium disordersHyperkalemiaSurveillance studyPatients