2022
RNAseq Analysis of Brain Aging in Wild Specimens of Short-Lived Turquoise Killifish: Commonalities and Differences With Aging Under Laboratory Conditions
Mazzetto M, Caterino C, Groth M, Ferrari E, Reichard M, Baumgart M, Cellerino A. RNAseq Analysis of Brain Aging in Wild Specimens of Short-Lived Turquoise Killifish: Commonalities and Differences With Aging Under Laboratory Conditions. Molecular Biology And Evolution 2022, 39: msac219. PMID: 36318827, PMCID: PMC9641980, DOI: 10.1093/molbev/msac219.Peer-Reviewed Original ResearchConceptsAge-dependent gene expressionWild populationsGene expressionDifferent model speciesNumber of genesGene regulationModel speciesCaptive populationsDNA replicationWild fishTemporary pondsWild specimensAge-dependent regulationCaptive conditionsRNAseq analysisAbundant foodWild animalsGenesAfrican savannahAsymptotic sizeRegulationNeuronal communicationFishLaboratory conditionsEnvironmental challenges
2020
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
Kelmer Sacramento E, Kirkpatrick J, Mazzetto M, Baumgart M, Bartolome A, Di Sanzo S, Caterino C, Sanguanini M, Papaevgeniou N, Lefaki M, Childs D, Bagnoli S, Terzibasi Tozzini E, Di Fraia D, Romanov N, Sudmant P, Huber W, Chondrogianni N, Vendruscolo M, Cellerino A, Ori A. Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation. Molecular Systems Biology 2020, 16: msb209596. PMID: 32558274, PMCID: PMC7301280, DOI: 10.15252/msb.20209596.Peer-Reviewed Original ResearchConceptsProtein homeostasisProteasome activityPost-transcriptional mechanismsAge-regulating proteinDriver of neurodegenerationProteome dynamicsProtein complexesTranscriptomic dataProtein aggregatesAge-related neurodegenerationProteomic signatureAssembly/Loss of stoichiometryProteasome levelsEarly eventsProteinHomeostasisProgressive lossNeurodegenerationCausative eventAging processTranscriptomicsNothobranchiusBrain agingRibosomes