Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
Kelmer Sacramento E, Kirkpatrick J, Mazzetto M, Baumgart M, Bartolome A, Di Sanzo S, Caterino C, Sanguanini M, Papaevgeniou N, Lefaki M, Childs D, Bagnoli S, Terzibasi Tozzini E, Di Fraia D, Romanov N, Sudmant P, Huber W, Chondrogianni N, Vendruscolo M, Cellerino A, Ori A. Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation. Molecular Systems Biology 2020, 16: msb209596. PMID: 32558274, PMCID: PMC7301280, DOI: 10.15252/msb.20209596.Peer-Reviewed Original ResearchConceptsProtein homeostasisProteasome activityPost-transcriptional mechanismsAge-regulating proteinDriver of neurodegenerationProteome dynamicsProtein complexesTranscriptomic dataProtein aggregatesAge-related neurodegenerationProteomic signatureAssembly/Loss of stoichiometryProteasome levelsEarly eventsProteinHomeostasisProgressive lossNeurodegenerationCausative eventAging processTranscriptomicsNothobranchiusBrain agingRibosomes