Mariateresa Mazzetto
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About
Titles
Postdoctoral Associate
Biography
Role: Postdoctoral Associate
Group: Prof. Valerie Reinke (Yale School of Medicine, Department of Genetics)
Project: I am studying C.elegans epigenome to identify the molecular pathways that play a role in germline progression, using both computational and experimental techniques.
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Mariateresa Mazzetto's published research.
Publications Timeline
A big-picture view of Mariateresa Mazzetto's research output by year.
Valerie Reinke, PhD
5Publications
175Citations
Publications
2023
Characterization of the distribution and dynamics of chromatin states in the C. elegans germ line reveals substantial H3K4me3 remodeling during oogenesis
Mazzetto M, Gonzalez L, Sanchez N, Reinke V. Characterization of the distribution and dynamics of chromatin states in the C. elegans germ line reveals substantial H3K4me3 remodeling during oogenesis. Genome Research 2023, 34: gr.278247.123. PMID: 38164610, PMCID: PMC10903938, DOI: 10.1101/gr.278247.123.Peer-Reviewed Original ResearchCitationsAltmetricConceptsEpigenetic regulatory mechanismsGerm lineChromatin stateGerm cellsC. elegans germ lineGene expressionRegulatory mechanismsDevelopmental transitionsActive histone modification H3K4me3Most genomic studiesZygotic genome activationSmall RNA pathwaysSpatio-temporal expression patternsHistone modifications H3K4me3Chromatin accessibility dataGerm cell differentiationOverall transcript abundanceUndifferentiated germ cellsGenome activationRNA pathwaysChromatin landscapeChromatin organizationChromatin structureEssential genesHistone modifications
2022
RNAseq Analysis of Brain Aging in Wild Specimens of Short-Lived Turquoise Killifish: Commonalities and Differences With Aging Under Laboratory Conditions
Mazzetto M, Caterino C, Groth M, Ferrari E, Reichard M, Baumgart M, Cellerino A. RNAseq Analysis of Brain Aging in Wild Specimens of Short-Lived Turquoise Killifish: Commonalities and Differences With Aging Under Laboratory Conditions. Molecular Biology And Evolution 2022, 39: msac219. PMID: 36318827, PMCID: PMC9641980, DOI: 10.1093/molbev/msac219.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAge-dependent gene expressionWild populationsGene expressionDifferent model speciesNumber of genesGene regulationModel speciesCaptive populationsDNA replicationWild fishTemporary pondsWild specimensAge-dependent regulationCaptive conditionsRNAseq analysisAbundant foodWild animalsGenesAfrican savannahAsymptotic sizeRegulationNeuronal communicationFishLaboratory conditionsEnvironmental challenges
2021
The zinc-finger protein OEF-1 stabilizes histone modification patterns and promotes efficient splicing in the Caenorhabditis elegans germline
McManus CE, Mazzetto M, Wei G, Han M, Reinke V. The zinc-finger protein OEF-1 stabilizes histone modification patterns and promotes efficient splicing in the Caenorhabditis elegans germline. G3: Genes, Genomes, Genetics 2021, 11: jkab329. PMID: 34519784, PMCID: PMC8664474, DOI: 10.1093/g3journal/jkab329.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsH3K36me3 levelsAutosomal lociC. elegans germ lineGerm cellsC. elegans germlineActive chromatin stateHistone modification patternsMES-4Chromatin stateEpigenetic balanceMutant phenotypeCaenorhabditis elegansSex chromosomesGenomic domainsGerm lineEfficient splicingDifferentiation programX chromosomeGenetic informationModification patternsTranscript integrityEfficient mRNANovel modifierH3K36me3Downstream effects
2020
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
Sacramento E, Kirkpatrick J, Mazzetto M, Baumgart M, Bartolome A, Di Sanzo S, Caterino C, Sanguanini M, Papaevgeniou N, Lefaki M, Childs D, Bagnoli S, Tozzini E, Di Fraia D, Romanov N, Sudmant P, Huber W, Chondrogianni N, Vendruscolo M, Cellerino A, Ori A. Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation. Molecular Systems Biology 2020, 16: e9596. PMID: 32558274, PMCID: PMC7301280, DOI: 10.15252/msb.20209596.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProtein homeostasisProteasome activityPost-transcriptional mechanismsAge-regulating proteinDriver of neurodegenerationProteome dynamicsProtein complexesTranscriptomic dataProtein aggregatesAge-related neurodegenerationProteomic signatureAssembly/Loss of stoichiometryProteasome levelsEarly eventsProteinHomeostasisProgressive lossNeurodegenerationCausative eventAging processTranscriptomicsNothobranchiusBrain agingRibosomes
2018
The age-regulated zinc finger factor ZNF367 is a new modulator of neuroblast proliferation during embryonic neurogenesis
Naef V, Monticelli S, Corsinovi D, Mazzetto M, Cellerino A, Ori M. The age-regulated zinc finger factor ZNF367 is a new modulator of neuroblast proliferation during embryonic neurogenesis. Scientific Reports 2018, 8: 11836. PMID: 30087422, PMCID: PMC6081467, DOI: 10.1038/s41598-018-30302-2.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGene co-regulation networksEmbryonic neurogenesisWeighted-gene co-expression network analysisAge-regulated genesCo-regulation networkCo-expression network analysisNeuroblast cell cycleProgression of mitosisCandidate gene approachAdult neural stem cellsGene lossSpindle checkpointNext-generation sequencingTranscription factorsZNF367Neural stem cellsGene approachCell cycleDisease coincidePhysiological functionsKey controllerCentral nervous systemNew modulatorsNeuroblast proliferationStem cells