Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake
Smith D, Mitchell S, Johnson M, Gibbs V, Dickinson S, Henschel B, Li R, Kaiser K, Chusyd D, Brown A, Allison D, Speakman J, Nagy T. Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake. GeroScience 2024, 46: 4809-4826. PMID: 38850387, PMCID: PMC11336014, DOI: 10.1007/s11357-024-01166-4.Peer-Reviewed Original ResearchProtein intakeCaloric restrictionPair-fedTNF-a levelsMale C57BL/6J miceBenefits of CRFat massC57BL/6J miceLean massTNF-aIGF-1Energy imbalanceMiceCalorie restrictionBenefits of calorie restrictionPhysical activityIntakeLongevity benefitsBody temperatureProtein intake per sePhysiological benefitsProteinLeptinExtended longevityHypothalamus