2021
Transcriptional network orchestrating regional patterning of cortical progenitors
Ypsilanti AR, Pattabiraman K, Catta-Preta R, Golonzhka O, Lindtner S, Tang K, Jones IR, Abnousi A, Juric I, Hu M, Shen Y, Dickel DE, Visel A, Pennachio LA, Hawrylycz M, Thompson CL, Zeng H, Barozzi I, Nord AS, Rubenstein JL. Transcriptional network orchestrating regional patterning of cortical progenitors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2024795118. PMID: 34921112, PMCID: PMC8713794, DOI: 10.1073/pnas.2024795118.Peer-Reviewed Original ResearchConceptsRegional patterningEnhancer-gene interactionsTranscription factor networkTF ChIP-seqExpression of hundredsCortical progenitorsVentricular zoneRadial glial stem cellsMutant miceEpigenomic marksTF networksDNA accessibilityGenomic programmingTranscriptional networksGlial stem cellsFactor networkChIP-seqStem cellsVZ cellsPatterningProgenitorsEnhancerMouse cortexExpressionCells
2016
Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate
Silberberg SN, Taher L, Lindtner S, Sandberg M, Nord AS, Vogt D, Mckinsey GL, Hoch R, Pattabiraman K, Zhang D, Ferran JL, Rajkovic A, Golonzhka O, Kim C, Zeng H, Puelles L, Visel A, Rubenstein JLR. Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate. Neuron 2016, 92: 59-74. PMID: 27710791, PMCID: PMC5063253, DOI: 10.1016/j.neuron.2016.09.027.Peer-Reviewed Original ResearchConceptsGABAergic cell fateEnhancer activityTranscriptional regulationCell fateNovel molecular mechanismStable transgenic mouse linesTranscriptional circuitryTransgenic linesTranscription factorsTranscriptional mechanismsDifferent enhancer elementsFate mapEnhancer elementsMolecular mechanismsTransgenic mouse lineForebrain developmentDistinct domainsMouse linesRegulationAmygdala neuronsBasal gangliaFateSpecific subtypesMutantsUnique tool
2015
Genomic Perspectives of Transcriptional Regulation in Forebrain Development
Nord AS, Pattabiraman K, Visel A, Rubenstein JL. Genomic Perspectives of Transcriptional Regulation in Forebrain Development. Neuron 2015, 85: 27-47. PMID: 25569346, PMCID: PMC4438709, DOI: 10.1016/j.neuron.2014.11.011.Peer-Reviewed Original ResearchConceptsCis-acting genomic elementsForebrain developmentGene expression statesGene expression programsAnalysis of chromatinGenomic regulatory mechanismsGenetic circuitryGenomic perspectiveExpression programsGenomic elementsTranscriptional regulationExpression statesHigher-order brain functionsTranscription factorsDNA modificationsGene expressionRegulatory mechanismsHuman neuropsychiatric disordersGenetic defectsCurrent knowledgeChromatinRecent progressEnhancerNeuropsychiatric disordersRegulation
2014
Transcriptional Regulation of Enhancers Active in Protodomains of the Developing Cerebral Cortex
Pattabiraman K, Golonzhka O, Lindtner S, Nord AS, Taher L, Hoch R, Silberberg SN, Zhang D, Chen B, Zeng H, Pennacchio LA, Puelles L, Visel A, Rubenstein JL. Transcriptional Regulation of Enhancers Active in Protodomains of the Developing Cerebral Cortex. Neuron 2014, 82: 989-1003. PMID: 24814534, PMCID: PMC4104757, DOI: 10.1016/j.neuron.2014.04.014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCerebral CortexCOUP Transcription Factor IEnhancer Elements, GeneticEye ProteinsGene Expression Regulation, DevelopmentalHippocampusHomeodomain ProteinsHumansMiceMice, TransgenicPaired Box Transcription FactorsPAX6 Transcription FactorPre-B-Cell Leukemia Transcription Factor 1Repressor ProteinsTranscription FactorsTranscription, Genetic