2024
Insights into SARS-CoV-2 Surveillance among Prison Populations in Mato Grosso do Sul, Brazil, in 2022
da Silva L, Alcantara L, Fonseca V, Frias D, Zardin M, de Castro Lichs G, Esposito A, Xavier J, Fritsch H, Lima M, de Oliveira C, de Arruda L, de Mello Almeida Maziero L, Barretos E, Oshiro P, Menezes E, de Freitas Cardoso L, Lemos E, Lourenço J, de Albuquerque C, do Carmo Said R, Rosewell A, Demarchi L, Croda J, Giovanetti M, Gonçalves C. Insights into SARS-CoV-2 Surveillance among Prison Populations in Mato Grosso do Sul, Brazil, in 2022. Viruses 2024, 16: 1143. PMID: 39066305, PMCID: PMC11281713, DOI: 10.3390/v16071143.Peer-Reviewed Original ResearchConceptsNext-generation sequencingPrison populationIncarcerated populationsOvercrowded cellsGenome sequenceGenomic characteristicsPrisonGenomic surveillanceEnclosed populationMato GrossoAverage coverageIsolation protocolSARS-CoV-2RT-qPCR testSARS-CoV-2 surveillanceRT-qPCRSequenceFrequent transferEpidemiological monitoringLimited healthcare accessGenomeCellsOmicron variant
2021
Risk Factors for Death Among 120,804 Hospitalized Patients with Confirmed COVID-19 in São Paulo, Brazil
da Silva P, de Oliveira S, Escalante J, Almiron M, Tsuha D, Sato H, Menezes P, de Paula R, D’Agostini T, Croda J. Risk Factors for Death Among 120,804 Hospitalized Patients with Confirmed COVID-19 in São Paulo, Brazil. American Journal Of Tropical Medicine And Hygiene 2021, 105: 88-92. PMID: 34061773, PMCID: PMC8274770, DOI: 10.4269/ajtmh.20-1598.Peer-Reviewed Original ResearchConceptsCOVID-19Confirmed COVID-19Characteristics of patientsChronic lung diseaseIntensive care unitChronic cardiovascular diseaseChronic neurological diseaseMore comorbiditiesClinical characteristicsDiabetes mellitusMedian ageCare unitLung diseaseRisk factorsCardiovascular diseaseHigh riskSevere casesElderly individualsPatientsNeurological diseasesSurvival analysisCoronavirus diseaseDiseaseSão PauloDeathEpidemiological study in Brazilian women highlights that syphilis remains a public health problem
dos Santos Barbosa M, de Lima L, Ribeiro S, Croda J, de Sá Queiroz J, Ortolani L, Negrão F, Souza E, da Silva K, de Souza R, Simionatto S. Epidemiological study in Brazilian women highlights that syphilis remains a public health problem. Revista Do Instituto De Medicina Tropical De São Paulo 2021, 63: e4. PMID: 33533807, PMCID: PMC7845940, DOI: 10.1590/s1678-9946202163004.Peer-Reviewed Original ResearchConceptsT. pallidum infectionSexual partnersPrimary health care unitsContinuous surveillance studiesGlobal public health concernHistory of STICross-sectional studyHigher prevalence ratioPublic health problemMultiple sexual partnersPopulation-based sampleHealth care unitsPublic health concernCommitment of patientsCare unitMultivariable analysisNeonatal deathPrevalence ratiosSyphilis testingSyphilis screeningReproductive ageRisk factorsBlood samplesEpidemiological studiesSurveillance study
2020
Prevalence, incidence and associated factors for HBV infection among male and female prisoners in Central Brazil: A multicenter study
Rezende G, Lago B, Puga M, Bandeira L, Pompilio M, Castro V, Tanaka T, Cesar G, Oliveira S, Yassuda R, Simionatto S, Weis S, Basílio S, Croda J, Motta-Castro A. Prevalence, incidence and associated factors for HBV infection among male and female prisoners in Central Brazil: A multicenter study. International Journal Of Infectious Diseases 2020, 96: 298-307. PMID: 32315810, DOI: 10.1016/j.ijid.2020.04.019.Peer-Reviewed Original ResearchConceptsHBV exposureHepatitis B virus infectionHCV/HBVIncidence of HBVHBV serological markersB virus infectionCross-sectional studyGenotypes/subtypesHBV infectionCohort studySerological markersHBV isolatesMulticenter studyHigh prevalenceLower incidenceVirus infectionHigh riskHBVNew casesBlood collectionFemale prisonersInfectionIncidencePreventive measuresPrevalenceEffect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
Borba M, Val F, Sampaio V, Alexandre M, Melo G, Brito M, Mourão M, Brito-Sousa J, Baía-da-Silva D, Guerra M, Hajjar L, Pinto R, Balieiro A, Pacheco A, Santos J, Naveca F, Xavier M, Siqueira A, Schwarzbold A, Croda J, Nogueira M, Romero G, Bassat Q, Fontes C, Albuquerque B, Daniel-Ribeiro C, Monteiro W, Lacerda M. Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. JAMA Network Open 2020, 3: e208857. PMID: 32330277, DOI: 10.1001/jamanetworkopen.2020.8857.Peer-Reviewed Original ResearchConceptsHigh dosage groupSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionAcute respiratory syndrome coronavirus 2 infectionLow dosage groupSyndrome coronavirus 2 infectionCoronavirus 2 infectionChloroquine diphosphateDay 13COVID-19Phase IIb clinical trialNonsevere COVID-19Secondary end pointsSevere COVID-19High-dose groupSpecific antiviral therapyTertiary care facilityIIb clinical trialCoronavirus disease 2019More heart diseaseParticipants' clinical statusAdjunctive therapyAdult patientsIll patientsPrimary outcomeAntiviral therapyImportation and early local transmission of COVID-19 in Brazil, 2020
de Jesus J, Sacchi C, da Silva Candido D, Claro I, Sales F, Manuli E, da Silva D, de Paiva T, Pinho M, de Oliveira Santos K, Hill S, Aguiar R, Romero F, dos Santos F, Gonçalves C, do Carmo Timenetsky M, Quick J, Croda J, de Oliveira W, Rambaut A, Pybus O, Loman N, Sabino E, Faria N. Importation and early local transmission of COVID-19 in Brazil, 2020. Revista Do Instituto De Medicina Tropical De São Paulo 2020, 62: e30. PMID: 32401959, PMCID: PMC7232955, DOI: 10.1590/s1678-9946202062030.Peer-Reviewed Original Research
2019
Investigation of Preanalytical Variables Impacting Pathogen Cell-Free DNA in Blood and Urine
Murugesan K, Hogan C, Palmer Z, Reeve B, Theron G, Andama A, Somoskovi A, Steadman A, Madan D, Andrews J, Croda J, Sahoo M, Cattamanchi A, Pinsky B, Banaei N. Investigation of Preanalytical Variables Impacting Pathogen Cell-Free DNA in Blood and Urine. Journal Of Clinical Microbiology 2019, 57: 10.1128/jcm.00782-19. PMID: 31511335, PMCID: PMC6813001, DOI: 10.1128/jcm.00782-19.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusCell-free DNABlood collection tubesUrine samplesLower medianPCR cycle thresholdCollection tubesEDTA blood samplesTB patientsTuberculosis patientsUrine volumeHealthy donorsBlood samplesAttractive biomarkerEDTA tubesPatient samplesBloodWhole urineThawed plasmaUrineUrine preservativeCycle thresholdMedianPatientsPreanalytical factorsHigh level of exposure to hepatitis B virus infection in a vulnerable population of a low endemic area: A challenge for vaccination coverage
Weis-Torres S, Fitts S, Cardoso W, Higa Junior M, Lima L, Bandeira L, Castro V, Carneiro F, Iglecias L, Cesar G, Tanaka T, Puga M, Rezende G, Croda J, Lago B, Motta-Castro A. High level of exposure to hepatitis B virus infection in a vulnerable population of a low endemic area: A challenge for vaccination coverage. International Journal Of Infectious Diseases 2019, 90: 46-52. PMID: 31589921, DOI: 10.1016/j.ijid.2019.09.029.Peer-Reviewed Original ResearchConceptsLow endemic areasHBV infectionHBV exposureEndemic areasHepatitis B virus infectionHIV serological markersB virus infectionHistory of surgeryHBV transmissionHBV vaccinationHBV vaccineHepatitis BChronic carriersSerological markersVaccination coverageHomosexual contactVirus infectionPrevalence ratesSusceptible adultsAge 18InfectionVulnerable populationsDisadvantaged populationsVaccinationMolecular featuresGenetic Diversity and Molecular Epidemiology of Mycobacterium tuberculosis in Roraima State, Brazil.
Tatara M, Perdigão J, Viveiros M, Kritski A, Silva K, Sacchi F, de Lima C, Dos Santos P, Diniz J, Almeida Silva P, Gomes P, Gomes M, Cunha E, Lapa E Silva J, Portugal I, Croda J, Andrade M. Genetic Diversity and Molecular Epidemiology of Mycobacterium tuberculosis in Roraima State, Brazil. American Journal Of Tropical Medicine And Hygiene 2019, 101: 774-779. PMID: 31392954, PMCID: PMC6779181, DOI: 10.4269/ajtmh.19-0324.Peer-Reviewed Original ResearchConceptsPopulation-based prospective studyDrug resistanceMolecular epidemiologyResistance profilesRepetitive units-variable numberMTB/RIFDrug susceptibility testDrug resistance profilesTransmission of MtbPublic health policyPhenotypic resistance profilesIsoniazid monoTB preventionProspective studyNew strain typesTB epidemiologyPrimary resistanceHigh prevalenceMTB isolatesProportion methodHealth policyMycobacterium tuberculosisSusceptibility testsTuberculosisVulnerable populationsHigh Prevalence of Syphilis and Inadequate Prenatal Care in Brazilian Pregnant Women: A Cross-Sectional Study.
Benedetti K, Ribeiro A, Queiroz J, Melo A, Batista R, Delgado F, da Silva K, Croda J, Simionatto S. High Prevalence of Syphilis and Inadequate Prenatal Care in Brazilian Pregnant Women: A Cross-Sectional Study. American Journal Of Tropical Medicine And Hygiene 2019, 101: 761-766. PMID: 31407659, PMCID: PMC6779194, DOI: 10.4269/ajtmh.18-0912.Peer-Reviewed Original ResearchConceptsPregnant womenHigh prevalenceVenereal Disease Research Laboratory testDisease Research Laboratory testSeroprevalence of syphilisUnlinked anonymous testingAntenatal care servicesInadequate prenatal careRisk factor questionnaireBrazilian pregnant womenBehavioral risk factorsCross-sectional studyPresence of antibodiesTime of deliveryData of newbornsHistory of abortionAntenatal careAnonymous testingThird trimesterFirst trimesterPrenatal careSectional studyClinical managementMedical recordsRisk factorsScreening for HBV, HCV, HIV and syphilis infections among bacteriologically confirmed tuberculosis prisoners: An urgent action required
Puga M, Bandeira L, Pompilio M, de Rezende G, Soares L, de Castro V, Tanaka T, Cesar G, de Oliveira S, Teles S, Yassuda R, dos Santos Weis-Torres S, Basílio S, Croda J, Motta-Castro A. Screening for HBV, HCV, HIV and syphilis infections among bacteriologically confirmed tuberculosis prisoners: An urgent action required. PLOS ONE 2019, 14: e0221265. PMID: 31437184, PMCID: PMC6705821, DOI: 10.1371/journal.pone.0221265.Peer-Reviewed Original ResearchConceptsHepatitis B virusSyphilis infectionViral hepatitisHIV infectionB virusAnti-HCV positive samplesChronic hepatitis B virusFirst-line anti-tuberculosis drugsLifetime syphilis infectionCases of tuberculosisAnti-TB drugsCross-sectional studyPublic health problemAnti-tuberculosis drugsCurrent HCVHCV exposureHCV RNAHepatitis testingTuberculosis infectionActive syphilisSerological markersEpidemiological featuresFrequent causeSide effectsHCVSafety and costs of blood transfusion practices in dengue cases in Brazil
Machado A, Negrão F, Croda J, de Medeiros E, dos Santos Pires M. Safety and costs of blood transfusion practices in dengue cases in Brazil. PLOS ONE 2019, 14: e0219287. PMID: 31283788, PMCID: PMC6613682, DOI: 10.1371/journal.pone.0219287.Peer-Reviewed Original ResearchConceptsHospital stayHospitalization timeHospitalisation timeWHO criteriaBlood transfusion componentsCost of hospitalisationWorld Health Organization recommendationsProspective observational studyBlood transfusion practicesPublic health problemTransfused groupBlood transfusionHospitalisation costsTransfusion practiceMedical recordsObservational studyTransfusion componentsWHO recommendationsPatientsTransfusionHealth problemsBlood componentsDengue casesStayHospitalisationSevere Leptospirosis Features in the Spleen Indicate Cellular Immunosuppression Similar to That Found in Septic Shock
Duarte-Neto A, Croda J, Pagliari C, Soriano F, Nicodemo A, Duarte M. Severe Leptospirosis Features in the Spleen Indicate Cellular Immunosuppression Similar to That Found in Septic Shock. Frontiers In Immunology 2019, 10: 920. PMID: 31114579, PMCID: PMC6503108, DOI: 10.3389/fimmu.2019.00920.Peer-Reviewed Original ResearchConceptsSeptic shockLeptospirosis patientsSevere leptospirosisPulmonary hemorrhagePositive cellsRed pulpBacterial septic shockSeptic shock patientsCaspase-3-positive cellsImmune cell markersSpleen of patientsActive caspase-3 positive cellsSemi-quantitative scoreImmunomodulatory treatmentShock patientsCellular immunosuppressionIL-10Immunologic featuresImmunosuppressive stateMarked atrophyEndothelial activationControl spleensHistological featuresIntense infiltrationPlasma cells
2018
A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit
da Silva K, Maciel W, Croda J, Cayô R, Ramos A, de Sales R, Kurihara M, Vasconcelos N, Gales A, Simionatto S. A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit. PLOS ONE 2018, 13: e0209367. PMID: 30592758, PMCID: PMC6310363, DOI: 10.1371/journal.pone.0209367.Peer-Reviewed Original ResearchMeSH KeywordsAcinetobacter baumanniiAcinetobacter InfectionsAdultAgedAged, 80 and overAnti-Bacterial AgentsBacterial ProteinsBeta-LactamasesBrazilCase-Control StudiesCross InfectionDrug Resistance, Multiple, BacterialFemaleHospital MortalityHumansIntensive Care UnitsMaleMicrobial Sensitivity TestsMiddle AgedConceptsOXA-23-producing A. baumanniiHigh mortality rateA. baumanniiMortality rateRisk factorsHealthcare-related risk factorsBrazilian intensive care unitsIntensive care unit patientsIntensive care unit settingCarbapenem-resistant Acinetobacter baumanniiISAba1 insertion sequenceA. baumannii infectionsCare unit patientsIntensive care unitBlaOXA-51 geneUse of cephalosporinsCase-control studyBaumannii infectionsUnit patientsCare unitNasogastric tubeTherapeutic optionsUnit settingNosocomial infectionsSuch infectionsAssessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response
Warsinske H, Rao A, Moreira F, Santos P, Liu A, Scott M, Malherbe S, Ronacher K, Walzl G, Winter J, Sweeney T, Croda J, Andrews J, Khatri P. Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response. JAMA Network Open 2018, 1: e183779. PMID: 30646264, PMCID: PMC6324428, DOI: 10.1001/jamanetworkopen.2018.3779.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntitubercular AgentsBrazilChildCohort StudiesDisease ProgressionFemaleGenes, BacterialGenetic MarkersHumansLatent TuberculosisMaleMiddle AgedMolecular TypingMycobacterium tuberculosisReal-Time Polymerase Chain ReactionReproducibility of ResultsRNA, BacterialSeverity of Illness IndexTuberculosisYoung AdultConceptsTB scoreAdolescent cohort studyNegative predictive valueTreatment responseTB diseaseCohort studyTuberculosis infectionTriage testPositron emission tomography-computed tomography scanPredictive valueLatent M tuberculosis infectionLatent Mycobacterium tuberculosis infectionPrimary health care clinicsHigh negative predictive valueCulture-positive adultsM tuberculosis infectionWhole bloodMycobacterium tuberculosis infectionEnd of treatmentHealth care clinicsCase-control studyIndependent prospective cohortsDiagnosis of tuberculosisSlower treatment responseCase-control cohortSuicide in Brazilian indigenous communities: clustering of cases in children and adolescents by household
Lazzarini TA, Gonçalves CCM, Benites WM, da Silva L, Tsuha DH, Ko AI, Rohrbaugh R, Andrews JR, Croda J. Suicide in Brazilian indigenous communities: clustering of cases in children and adolescents by household. Revista De Saúde Pública 2018, 52: 56. PMID: 29791676, PMCID: PMC5958965, DOI: 10.11606/s1518-8787.2018052000541.Peer-Reviewed Original ResearchConceptsHealth interventionsSuicide ratesHousehold clustersRetrospective cohort studyBroader public health interventionsConclusions High ratesPublic health interventionsMental health interventionsHigh rateCohort studyHigh suicide ratesLower socioeconomic indicatorsAdult suicideAdolescent malesOverall suicide ratesChildrenSuicideGreater proportionChild suicideInterventionSocioeconomic indicatorsAdolescentsIndigenous individualsSuicide clusteringTreatment Outcomes of Brazilian Inmates with Treponema pallidum and Human Immunodeficiency Virus Infection: A Prospective Cohort Study.
Bet G, Souza G, Croda J, Correa M, de Sales R, Santos R, Viebrantz Enne Sgarbi R, Yassuda R, Coimbra Motta-Castro A, Pompílio M, Simionatto S. Treatment Outcomes of Brazilian Inmates with Treponema pallidum and Human Immunodeficiency Virus Infection: A Prospective Cohort Study. American Journal Of Tropical Medicine And Hygiene 2018, 98: 1603-1608. PMID: 29737273, PMCID: PMC6086195, DOI: 10.4269/ajtmh.17-0592.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHIV-1 viral loadProspective cohort studyPoor treatment outcomesTreatment outcomesCohort studyHIV infectionViral loadHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionCopies/mLMedical record dataPublic health programsSyphilis treatmentImmunodeficiency virusAcquired syphilisRisk factorsSerological testingVirus infectionBlood samplesMultivariate analysisHealth programsNew casesInfectionTreponema pallidum
2017
Genetic Clustering of Tuberculosis in an Indigenous Community of Brazil.
Correia Sacchi F, Tatara M, Camioli de Lima C, Ferreia da Silva L, Cunha E, Simonsen V, Ferrazoli L, Gomes H, Gonçalves Vasconcellos S, Suffys P, Andrews J, Croda J. Genetic Clustering of Tuberculosis in an Indigenous Community of Brazil. American Journal Of Tropical Medicine And Hygiene 2017, 98: 372-375. PMID: 29210353, PMCID: PMC5929193, DOI: 10.4269/ajtmh.17-0480.Peer-Reviewed Original ResearchHigh Prevalence of Treponema pallidum Infection in Brazilian Prisoners.
Correa ME, Croda J, Coimbra Motta de Castro AR, Maria do Valle Leone de Oliveira S, Pompilio MA, Omizolo de Souza R, Ferreira de Sá Queiroz JH, Esther da Silva K, Ko AI, Simionatto S. High Prevalence of Treponema pallidum Infection in Brazilian Prisoners. American Journal Of Tropical Medicine And Hygiene 2017, 97: 1078-1084. PMID: 28820706, PMCID: PMC5637599, DOI: 10.4269/ajtmh.17-0098.Peer-Reviewed Original ResearchConceptsActive syphilisSyphilis prevalenceHigh prevalenceBrazilian prisonersHuman immunodeficiency virus statusGenital ulcer diseaseIntravenous drug usersHigh-risk groupUnprotected sexual practicesMultivariable regression analysisCross-sectional studyActive syphilis prevalenceNew syphilis casesPopulation-based sampleDevelopment of syphilisCongenital infectionUlcer diseaseSyphilis testingRisk factorsVirus statusScreening programSerological statusSyphilis casesSevere formDrug usersResistência às drogas antituberculose na fronteira do Brasil com Paraguai e Bolívia
Marques M, Cunha E, do Socorro Nantua Evangelista M, Basta P, Marques A, Croda J, de Andrade S. Resistência às drogas antituberculose na fronteira do Brasil com Paraguai e Bolívia. BULL PAN AM HEALTH ORGAN 2017, 41: 1. PMID: 28444009, PMCID: PMC6645181, DOI: 10.26633/rpsp.2017.9.Peer-Reviewed Original ResearchConceptsObserved treatmentDrug resistanceAssociated risk factorsPulmonary tuberculosis casesHistory of alcoholismCases of PTBCombination of drugsPatterns of resistanceRespiratory symptomsPTB casesTuberculosis casesDevelopment of resistanceRisk factorsEpidemiological studiesSingle drugHealth actionsSusceptibility testingMultidrug resistanceDiabetesSusceptibility testsAlcoholismPatientsDrugsTreatmentPresence/absence