Methionine restriction beyond life‐span extension
Ables GP, Hens JR, Nichenametla SN. Methionine restriction beyond life‐span extension. Annals Of The New York Academy Of Sciences 2016, 1363: 68-79. PMID: 26916321, DOI: 10.1111/nyas.13014.Peer-Reviewed Original ResearchConceptsMethionine restrictionLife span extensionPossible downstream effectorsMitochondrial oxidative stressAge-related diseasesCystathionine β-synthaseIntracellular regulatory mechanismsEpigenetic mechanismsNoncoding RNAsDownstream effectorsSpecific genesReactive oxygen speciesRegulatory mechanismsCell cycleBody sizeMethionine cycleEpigeneticsCancer progressionΒ-synthaseDietary methionine restrictionCell apoptosisFactor 1Fibroblast growth factor 21Hepatic glucose metabolismInsulin-like growth factor-1