2017
METHIONINE RESTRICTION ALTERS HEPATIC MIRNAS INVOLVED IN METABOLISM IN YOUNG, OBESE, AND AGED MICE
Park M, Cooke D, Plummer J, Ables G, Hens J. METHIONINE RESTRICTION ALTERS HEPATIC MIRNAS INVOLVED IN METABOLISM IN YOUNG, OBESE, AND AGED MICE. Innovation In Aging 2017, 1: 857-857. PMCID: PMC6184731, DOI: 10.1093/geroni/igx004.3084.Peer-Reviewed Original ResearchDIO miceAged miceMethionine restrictionYoung miceNonalcoholic fatty liver diseaseDiet-induced obese miceMiR-33-5pFatty liver conditionFatty liver diseaseDietary methionine restrictionType II diabetesExpression of mRNAAge-associated disordersBile acid transportLiver diseaseLiver functionObese miceLet-7gLiver conditionsMR dietOld miceHepatic expressionTransport of cholesterolBile acidsII diabetes
2016
Methionine‐Restricted Diet Increases miRNAs That Can Target RUNX2 Expression and Alters Bone Structure in Young Mice
Plummer J, Park M, Perodin F, Horowitz MC, Hens JR. Methionine‐Restricted Diet Increases miRNAs That Can Target RUNX2 Expression and Alters Bone Structure in Young Mice. Journal Of Cellular Biochemistry 2016, 118: 31-42. PMID: 27191548, PMCID: PMC5426510, DOI: 10.1002/jcb.25604.Peer-Reviewed Original ResearchConceptsDietary methionine restrictionBone tissue densityMR miceMethionine restrictionBone marrowMale C57BL/6J miceBone-related biomarkersYoung male C57BL/6J miceBone structureMiR-335-5pPlasma levelsC57BL/6J micePlasma glucoseRodent modelsBone volumeFat depotsTrabecular thicknessFat accretionBone remodelingMiceBiomechanical testingMiR-204Reduced expressionMiR-31Significant decreaseMethionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice
Hens JR, Sinha I, Perodin F, Cooper T, Sinha R, Plummer J, Perrone CE, Orentreich D. Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice. BMC Cancer 2016, 16: 349. PMID: 27255182, PMCID: PMC4891836, DOI: 10.1186/s12885-016-2367-1.Peer-Reviewed Original ResearchConceptsMethionine restrictionMR miceMR dietCell cycle inhibitorsNude micePlasma amino acid concentrationsBreast cancer xenograft modelCancer xenograft modelAthymic nude miceBreast cancer cell linesTumors of miceCycle inhibitorsMDA-MB-231 cellsConventional cancer therapiesAqueous One Solution Cell ProliferationCell Titer 96MDA-MB-231Cancer cell linesProgression of cancerInsulin sensitivityMammary gland tissuePlasma concentrationsMammary tumorsSmall tumorsAmino acid concentrationsMethionine restriction beyond life‐span extension
Ables GP, Hens JR, Nichenametla SN. Methionine restriction beyond life‐span extension. Annals Of The New York Academy Of Sciences 2016, 1363: 68-79. PMID: 26916321, DOI: 10.1111/nyas.13014.Peer-Reviewed Original ResearchConceptsMethionine restrictionLife span extensionPossible downstream effectorsMitochondrial oxidative stressAge-related diseasesCystathionine β-synthaseIntracellular regulatory mechanismsEpigenetic mechanismsNoncoding RNAsDownstream effectorsSpecific genesReactive oxygen speciesRegulatory mechanismsCell cycleBody sizeMethionine cycleEpigeneticsCancer progressionΒ-synthaseDietary methionine restrictionCell apoptosisFactor 1Fibroblast growth factor 21Hepatic glucose metabolismInsulin-like growth factor-1