2021
Podocyte Glucocorticoid Receptors Are Essential for Glomerular Endothelial Cell Homeostasis in Diabetes Mellitus
Srivastava SP, Zhou H, Setia O, Dardik A, Fernandez‐Hernando C, Goodwin J. Podocyte Glucocorticoid Receptors Are Essential for Glomerular Endothelial Cell Homeostasis in Diabetes Mellitus. Journal Of The American Heart Association 2021, 10: e019437. PMID: 34308664, PMCID: PMC8475689, DOI: 10.1161/jaha.120.019437.Peer-Reviewed Original ResearchConceptsDiabetic nephropathySegmental fibrosisFatty acid metabolismDiabetes mellitusEndothelial cellsPrimary podocytesReceptor knockout micePathogenesis of proteinuriaAdministration of streptozotocinProfibrotic gene expressionAcid metabolismGlomerular endothelial cellsSmooth muscle actinEndothelial cell homeostasisCarnitine palmitoyltransferase 1AFatty acid oxidationBackground ProteinuriaWorsened fibrosisClinical characteristicsFibrotic featuresGlomerular fibrosisGlomerular homeostasisPatient managementControl littermatesSevere disease
2019
Role of the glucocorticoid receptor in glomerular disease
Goodwin JE. Role of the glucocorticoid receptor in glomerular disease. American Journal Of Physiology. Renal Physiology 2019, 317: f133-f136. PMID: 31166704, PMCID: PMC6692724, DOI: 10.1152/ajprenal.00217.2019.Peer-Reviewed Original ResearchConceptsGlomerular diseasePotent anti-inflammatory agentSteroid delivery systemsAnti-inflammatory agentsSystemic steroidsBeneficial direct effectsUnfavorable riskSystemic administrationTherapeutic benefitGlucocorticoid receptorRisk assessment algorithmClinicians' effortsBenefit ratioVivo studiesGlucocorticoidsDiseasePersonalized medicineDirect effectDelivery systemGlomeruliSteroidsAdministrationPodocytesReceptors