2021
Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection
McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PLOS ONE 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionYale New Haven HealthSARS-CoV-2Hospital mortalityRisk of admissionMale sexRisk factorsSARS-CoV-2 testingInvasive mechanical ventilationSevere acute respiratory syndrome virusBurden of diseaseRT-PCR testingAcademic health systemDiverse patient populationsRespiratory syndrome virusEthnic groupsAdult patientsClinical characteristicsDischarge dispositionRespiratory supportPrimary outcomeTreatment guidelinesMechanical ventilationRetrospective studyPatient population
2020
Abnormalities of Aspiration and Swallowing Function in Survivors of Acute Respiratory Failure
Langmore SE, Krisciunas GP, Warner H, White SD, Dvorkin D, Fink D, McNally E, Scheel R, Higgins C, Levitt JE, McKeehan J, Deane S, Siner JM, Vojnik R, Moss M. Abnormalities of Aspiration and Swallowing Function in Survivors of Acute Respiratory Failure. Dysphagia 2020, 36: 831-841. PMID: 33156398, DOI: 10.1007/s00455-020-10199-8.Peer-Reviewed Original ResearchConceptsAcute respiratory failureRespiratory failureARF survivorsMechanical ventilationMultivariable analysisUniversity-based tertiary medical centerPenetration-Aspiration Scale scoresUpper airway edemaProspective cohort studyTertiary medical centerLaryngeal structuresFlexible endoscopic evaluationAirway edemaARF patientsSecondary outcomesCohort studyFunction abnormalitiesPrimary outcomeEndoscopic evaluationPharyngeal weaknessSwallowing examinationSwallowing functionIntensive carePhysiologic abnormalitiesUnivariate analysisDevelopment of an Accurate Bedside Swallowing Evaluation Decision Tree Algorithm for Detecting Aspiration in Acute Respiratory Failure Survivors
Moss M, White SD, Warner H, Dvorkin D, Fink D, Gomez-Taborda S, Higgins C, Krisciunas GP, Levitt JE, McKeehan J, McNally E, Rubio A, Scheel R, Siner JM, Vojnik R, Langmore SE. Development of an Accurate Bedside Swallowing Evaluation Decision Tree Algorithm for Detecting Aspiration in Acute Respiratory Failure Survivors. CHEST Journal 2020, 158: 1923-1933. PMID: 32721404, PMCID: PMC7674978, DOI: 10.1016/j.chest.2020.07.051.Peer-Reviewed Original ResearchConceptsAcute respiratory failure survivorsNegative predictive valueHigh riskMulticenter prospective studyRisk of aspirationFlexible endoscopic evaluationRecursive partitioning analysisDetection of aspirationARF survivorsEndoscopic evaluationAirway safetyMechanical ventilationMedian timeAspiration riskProspective studyPatientsPredictive valueStudy designFinal analysisStudy proceduresGold standard evaluationSurvivorsThin liquidsExtubationPartitioning analysis
2019
Relationship Between Laryngeal Sensation, Length of Intubation, and Aspiration in Patients with Acute Respiratory Failure
Borders JC, Fink D, Levitt JE, McKeehan J, McNally E, Rubio A, Scheel R, Siner JM, Taborda SG, Vojnik R, Warner H, White SD, Langmore SE, Moss M, Krisciunas GP. Relationship Between Laryngeal Sensation, Length of Intubation, and Aspiration in Patients with Acute Respiratory Failure. Dysphagia 2019, 34: 521-528. PMID: 30694412, PMCID: PMC6660370, DOI: 10.1007/s00455-019-09980-1.Peer-Reviewed Original ResearchConceptsLaryngeal adductor reflexLength of intubationLaryngeal sensationMechanical ventilationDiet recommendationsAbsent laryngeal adductor reflexAcute respiratory failure patientsIntensive care unit admissionLaryngeal sensory deficitsAcute respiratory failureCare unit admissionRespiratory failure patientsPost-extubation dysphagiaFlexible endoscopic evaluationPresence of secretionsUnit admissionRespiratory failureAirway protectionFailure patientsSecondary outcomesEndoscopic evaluationHospitalized patientsMultivariable analysisPoor outcomeSensory deficits
2015
Protocols and Hospital Mortality in Critically Ill Patients
Sevransky JE, Checkley W, Herrera P, Pickering BW, Barr J, Brown SM, Chang SY, Chong D, Kaufman D, Fremont RD, Girard TD, Hoag J, Johnson SB, Kerlin MP, Liebler J, O’Brien J, O’Keefe T, Park PK, Pastores SM, Patil N, Pietropaoli AP, Putman M, Rice TW, Rotello L, Siner J, Sajid S, Murphy DJ, Martin GS. Protocols and Hospital Mortality in Critically Ill Patients. Critical Care Medicine 2015, 43: 2076-2084. PMID: 26110488, PMCID: PMC5673100, DOI: 10.1097/ccm.0000000000001157.Peer-Reviewed Original ResearchConceptsHospital mortalityIll patientsProtocol complianceClinical protocolsUnited States Critical IllnessAcute respiratory distress syndromeSpontaneous breathing trialLung-protective ventilationRespiratory distress syndromeLength of stayComplete outcome dataPatients 1 dayVentilator management protocolsSuperior patient outcomesLack of associationSingle variable analysisDesirable therapyBreathing trialProtective ventilationCritical illnessDistress syndromeICU protocolPrimary outcomeMechanical ventilationMultivariable analysis
2007
Mechanical Ventilation and Acute Respiratory Distress Syndrome in Older Patients
Siner JM, Pisani MA. Mechanical Ventilation and Acute Respiratory Distress Syndrome in Older Patients. Clinics In Chest Medicine 2007, 28: 783-791. PMID: 17967294, DOI: 10.1016/j.ccm.2007.08.008.BooksConceptsAcute respiratory distress syndromeRespiratory distress syndromeDistress syndromeMechanical ventilationAcute respiratory failureAcute lung injuryIntensive care unitUnited States agesRespiratory failureLung injuryOlder patientsCare unitFunctional outcomeIncidence rateRespiratory functionAge-specific changesElderly adultsPatient careRespiratory systemSyndromeStates agesAgeVentilationARDSPatients