2024
Early Warning Scores With and Without Artificial Intelligence
Edelson D, Churpek M, Carey K, Lin Z, Huang C, Siner J, Johnson J, Krumholz H, Rhodes D. Early Warning Scores With and Without Artificial Intelligence. JAMA Network Open 2024, 7: e2438986. PMID: 39405061, DOI: 10.1001/jamanetworkopen.2024.38986.Peer-Reviewed Original ResearchConceptsEarly Warning ScoreWarning ScoreCohort studyYale New Haven Health SystemClinical deterioration eventsHigh-risk thresholdHealth systemRetrospective cohort studyPatient encountersDeteriorating patientsOverall PPVMain OutcomesInpatient encountersEDI scoresHospital encountersDeterioration eventsClinical deteriorationIntensive care unitEarly warning toolCare unitDecision support toolArtificial intelligenceScoresReceiver operating characteristic curveNEWS2
2020
Abnormalities of Aspiration and Swallowing Function in Survivors of Acute Respiratory Failure
Langmore SE, Krisciunas GP, Warner H, White SD, Dvorkin D, Fink D, McNally E, Scheel R, Higgins C, Levitt JE, McKeehan J, Deane S, Siner JM, Vojnik R, Moss M. Abnormalities of Aspiration and Swallowing Function in Survivors of Acute Respiratory Failure. Dysphagia 2020, 36: 831-841. PMID: 33156398, DOI: 10.1007/s00455-020-10199-8.Peer-Reviewed Original ResearchConceptsAcute respiratory failureRespiratory failureARF survivorsMechanical ventilationMultivariable analysisUniversity-based tertiary medical centerPenetration-Aspiration Scale scoresUpper airway edemaProspective cohort studyTertiary medical centerLaryngeal structuresFlexible endoscopic evaluationAirway edemaARF patientsSecondary outcomesCohort studyFunction abnormalitiesPrimary outcomeEndoscopic evaluationPharyngeal weaknessSwallowing examinationSwallowing functionIntensive carePhysiologic abnormalitiesUnivariate analysisThe Association Between Endotracheal Tube Size and Aspiration (During Flexible Endoscopic Evaluation of Swallowing) in Acute Respiratory Failure Survivors.
Krisciunas GP, Langmore SE, Gomez-Taborda S, Fink D, Levitt JE, McKeehan J, McNally E, Scheel R, Rubio AC, Siner JM, Vojnik R, Warner H, White SD, Moss M. The Association Between Endotracheal Tube Size and Aspiration (During Flexible Endoscopic Evaluation of Swallowing) in Acute Respiratory Failure Survivors. Critical Care Medicine 2020, 48: 1604-1611. PMID: 32804785, PMCID: PMC7644217, DOI: 10.1097/ccm.0000000000004554.Peer-Reviewed Original ResearchConceptsEndotracheal tube sizeFlexible endoscopic evaluationSilent aspirationEndoscopic evaluationMedical recordsEndotracheal tubeGranulation tissueAcademic tertiary care medical centerAcute respiratory failure survivorsTertiary care medical centerPenetration-Aspiration Scale scoresAcute respiratory failureModifiable risk factorsProspective cohort studyThird of patientsHours of extubationRisk of aspirationSmall endotracheal tubePatients' medical recordsHospital outcomesRespiratory failureCohort studyPatient demographicsSwallowing examinationMultivariable analysis
2016
“Deterioration to Door Time”: An Exploratory Analysis of Delays in Escalation of Care for Hospitalized Patients
Sankey CB, McAvay G, Siner JM, Barsky CL, Chaudhry SI. “Deterioration to Door Time”: An Exploratory Analysis of Delays in Escalation of Care for Hospitalized Patients. Journal Of General Internal Medicine 2016, 31: 895-900. PMID: 26969311, PMCID: PMC4945556, DOI: 10.1007/s11606-016-3654-x.Peer-Reviewed Original ResearchConceptsMedical intensive care unitEscalation of careIntensive care unitClinical deteriorationCare escalationHospitalized patientsCare unitDoor timeInpatient medicineRetrospective cohort studySeverity of illnessRisk of deathAcademic medical centerHospital mortalityICU transferCohort studyInpatient floorInpatient settingMedical CenterGeneral floorPatientsCareMortalityCurrent eraPrevious studies
2015
Oral Alimentation in Neonatal and Adult Populations Requiring High-Flow Oxygen via Nasal Cannula
Leder SB, Siner JM, Bizzarro MJ, McGinley BM, Lefton-Greif MA. Oral Alimentation in Neonatal and Adult Populations Requiring High-Flow Oxygen via Nasal Cannula. Dysphagia 2015, 31: 154-159. PMID: 26590570, DOI: 10.1007/s00455-015-9669-3.Peer-Reviewed Original ResearchConceptsOral alimentationOral feedingNasal cannulaMedical conditionsIntensive care unit settingPatient-specific determinantsAdult ICU patientsHigh-flow oxygenUnderlying medical conditionsFunctional swallowSwallow testingAdult patientsCohort studyRespiratory supportICU patientsICU inpatientsFlow oxygenUnit settingRespiratory issuesPatientsAdult populationHigh acuityParticipant characteristicsSuccessful resumptionAlimentation
2009
ELEVATED SERUM ANGIOPOIETIN 2 LEVELS ARE ASSOCIATED WITH INCREASED MORTALITY IN SEPSIS
Siner JM, Bhandari V, Engle KM, Elias JA, Siegel MD. ELEVATED SERUM ANGIOPOIETIN 2 LEVELS ARE ASSOCIATED WITH INCREASED MORTALITY IN SEPSIS. Shock 2009, 31: 348-353. PMID: 18791490, DOI: 10.1097/shk.0b013e318188bd06.Peer-Reviewed Original ResearchConceptsAng-2 levelsIntensive care unitAng-2Tertiary care medical intensive care unitProspective observational cohort studySerum Ang-2 levelsSerum angiopoietin-2 levelsMedical intensive care unitSerum Ang-2Observational cohort studyAngiopoietin-2 levelsIL-6 levelsHospital mortalityHuman sepsisICU admissionSevere sepsisCohort studyEndothelial dysfunctionHospital dischargeICU patientsIllness scoresSeptic shockCare unitIL-6Increased Mortality