2024
P31. Testosterone replacement therapy associated with increased 90-day postoperative adverse events and 5-year reoperation following lumbar discectomy
Seddio A, Gouzoulis M, Smith-Voudouris J, Rubio D, Day W, Grauer J. P31. Testosterone replacement therapy associated with increased 90-day postoperative adverse events and 5-year reoperation following lumbar discectomy. The Spine Journal 2024, 24: s78. DOI: 10.1016/j.spinee.2024.06.052.Peer-Reviewed Original ResearchTestosterone replacement therapyAcute kidney injuryLumbar discectomyAdverse eventsMale patientsOdds ratioCurrent Procedural TerminologyReoperation ratePostoperative outcomesElixhauser Comorbidity IndexPostoperative recoveryMultivariate analysisSingle-level lumbar discectomyTestosterone replacement therapy patientsMyocardial infarctionOrthopedic surgeryKaplan-Meier survival analysisEmergency departmentLumbar spinal proceduresLog-rank testMonths of surgeryRetrospective cohort studyPostoperative adverse eventsEnhanced postoperative recoveryMinor adverse eventsOutcomes following two-level Cervical Disc Arthroplasty Relative to two-level Anterior Cervical Discectomy.
Ratnasamy P, Gouzoulis M, Jabbouri S, Varthi A, Grauer J. Outcomes following two-level Cervical Disc Arthroplasty Relative to two-level Anterior Cervical Discectomy. Spine 2024 PMID: 39190404, DOI: 10.1097/brs.0000000000005131.Peer-Reviewed Original ResearchCervical disc arthroplasty patientsFive-year survivalCervical disc arthroplastyPostoperative adverse eventsSpine reoperationTwo-level cervical disc arthroplastyAdverse eventsACDF patientsPatient ageElixhauser Comorbidity IndexTreatment optionsMultivariate analysisDegenerative cervical spine pathologyTwo-level surgeryCervical spine pathologyTwo-level ACDFAnterior cervical discectomyNovel treatment optionsMinor adverse eventsCervical discectomyNo significant differenceSpine pathologyACDFReoperationComorbidity indexOne- versus Three-- Level Fusion in Patients Undergoing Multilevel Lumbar Decompression: Relative Perioperative Risks and Five-year Revisions.
Ratnasamy P, Gouzoulis M, Jabbouri S, Rubio D, Grauer J. One- versus Three-- Level Fusion in Patients Undergoing Multilevel Lumbar Decompression: Relative Perioperative Risks and Five-year Revisions. Spine 2024 PMID: 39190416, DOI: 10.1097/brs.0000000000005130.Peer-Reviewed Original ResearchOne-level fusionLumbar decompressionThree-level fusionPostoperative adverse eventsAdverse eventsOdds ratioElixhauser Comorbidity IndexPatient ageFive-year survivalOdds of perioperative complicationsLumbar decompression patientsPerioperative complicationsDecompression patientsPerioperative riskFusion patientsSpinal reoperationLumbar fusionReoperationComorbidity indexMultivariate analysisPatientsClinical interestDecompressionFusion levelsOddsOutcomes Following Total Hip Arthroplasty in Patients Who Have Von Willebrand Disease Depend on Postoperative Anticoagulation
Jiang W, Sanchez J, Dhodapkar M, Radford Z, Rubin L, Grauer J. Outcomes Following Total Hip Arthroplasty in Patients Who Have Von Willebrand Disease Depend on Postoperative Anticoagulation. The Journal Of Arthroplasty 2024, 39: 2088-2093. PMID: 38462141, DOI: 10.1016/j.arth.2024.03.004.Peer-Reviewed Original ResearchVon Willebrand diseaseVon Willebrand disease patientsRevision-free survivalVenous thromboembolismAdverse eventsOdds of venous thromboembolismTotal hip arthroplastyIncreased oddsDefects of von Willebrand factorCongenital bleeding disordersPatients to dateQualitative defects of von Willebrand factorPostoperative adverse eventsThrombotic adverse eventsMultivariate logistic regressionAutosomal dominant conditionVon Willebrand factorElixhauser Comorbidity IndexBleeding disordersPostoperative anticoagulationAdult patientsCompare bleedingPrescription patternsQualitative defectsWillebrand diseaseFemoral Head Core Decompressions: Characterization of Subsequent Conversion to Total Hip Arthroplasty and Related Complications
Jiang W, Sanchez J, Dhodapkar M, Li M, Wiznia D, Grauer J. Femoral Head Core Decompressions: Characterization of Subsequent Conversion to Total Hip Arthroplasty and Related Complications. JAAOS Global Research And Reviews 2024, 8: e24.00024. PMID: 38437034, PMCID: PMC10906578, DOI: 10.5435/jaaosglobal-d-24-00024.Peer-Reviewed Original Research
2023
Ninety day adverse events following single level posterior lumbar interbody fusion in patients with sickle cell disease
Dhodapkar M, Halperin S, Saifi C, Whang P, Grauer J, Varthi A. Ninety day adverse events following single level posterior lumbar interbody fusion in patients with sickle cell disease. The Spine Journal 2023, 24: 807-811. PMID: 38081460, DOI: 10.1016/j.spinee.2023.11.025.Peer-Reviewed Original ResearchPosterior lumbar interbody fusionSingle-level posterior lumbar interbody fusionSickle cell diseaseElixhauser Comorbidity IndexAdverse eventsPostoperative outcomesInterbody fusionOdds ratioCell diseaseDays adverse eventsMinor adverse eventsPostoperative adverse eventsPerioperative adverse eventsSevere adverse eventsCohort of patientsED visit ratesEmergency department visitsMultivariable logistic regressionNational administrative databaseRetrospective database studyLumbar interbody fusionSingle level posteriorComorbidity indexPLIF patientsAdult patientsLumbar Laminotomy: Variables Affecting 90-day Overall Reimbursement
Halperin S, Dhodapkar M, Gouzoulis M, Laurans M, Varthi A, Grauer J. Lumbar Laminotomy: Variables Affecting 90-day Overall Reimbursement. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 32: 265-270. PMID: 38064482, DOI: 10.5435/jaaos-d-23-00365.Peer-Reviewed Original ResearchPostoperative adverse eventsAdverse eventsInsurance typePostoperative emergency department visitsPostoperative emergency departmentEmergency department visitsElixhauser Comorbidity IndexMultivariable linear regression modelsMultivariable linear regressionHealthcare deliveryIndications of traumaPostoperative readmissionsComorbidity indexInfectious diagnosisConservative treatmentPerioperative dataDepartment visitsEmergency departmentOutpatient surgeryLarge cohortSpinal proceduresExclusion criteriaDiskectomyOverall reimbursementCommon procedureTotal Hip Arthroplasty in Patients Who Have Marfan Syndrome: Adverse Events and 5-Year Revision Rates
Day W, Jayaram R, Rubin L, Grauer J. Total Hip Arthroplasty in Patients Who Have Marfan Syndrome: Adverse Events and 5-Year Revision Rates. The Journal Of Arthroplasty 2023 PMID: 37952742, DOI: 10.1016/j.arth.2023.10.052.Peer-Reviewed Original ResearchTotal hip arthroplastyAdverse eventsMarfan syndromeMultivariable analysisHip arthroplastyUnderwent total hip arthroplastyPostoperative adverse eventsVenous thromboembolic eventsPerioperative care pathwaysUrinary tract infectionConnective tissue diseaseLog-rank testRare disease populationComorbidity indexThromboembolic eventsCardiac eventsPostoperative courseTract infectionsAdult patientsTissue diseaseHip pathologyRevision rateCare pathwayDisease populationGreater oddsTotal Knee Arthroplasty: Variables Affecting 90-day Overall Reimbursement
Halperin S, Dhodapkar M, Radford Z, Li M, Rubin L, Grauer J. Total Knee Arthroplasty: Variables Affecting 90-day Overall Reimbursement. The Journal Of Arthroplasty 2023, 38: 2259-2263. PMID: 37279847, DOI: 10.1016/j.arth.2023.05.072.Peer-Reviewed Original ResearchConceptsTotal knee arthroplastyTKA patientsPrimary total knee arthroplastyPostoperative emergency departmentPostoperative adverse eventsRisk of readmissionMultivariable linear regressionPerioperative periodPostoperative eventsAdverse eventsAppropriate patientsKnee osteoarthritisEmergency departmentPatients surgeryKnee arthroplastyOncologic indicationsCost-containment strategiesSurgical proceduresExclusion criteriaPatientsOptimize deliveryOverall reimbursementAdmissionReimbursementGreater increase
2022
Total Hip Arthroplasty Imageless Navigation Does Not Reduce 90-Day Adverse Events or Five-Year Revisions in a Large National Cohort
Jayaram R, Gillinov S, Caruana D, Kammien A, Joo P, Rubin L, Grauer J. Total Hip Arthroplasty Imageless Navigation Does Not Reduce 90-Day Adverse Events or Five-Year Revisions in a Large National Cohort. The Journal Of Arthroplasty 2022, 38: 862-867. PMID: 36529197, DOI: 10.1016/j.arth.2022.12.012.Peer-Reviewed Original ResearchConceptsTotal hip arthroplastyAdverse eventsImageless navigationMultivariate analysisLarge national administrative databaseElixhauser comorbidity index scorePrimary total hip arthroplastyComorbidity Index scoreFive-year incidencePostoperative adverse eventsNational administrative databaseLarge national cohortLarge national databaseCause revisionTHA patientsWound dehiscenceNational cohortTHA casesAdministrative databasesDislocation rateHip arthroplastyHigher oddsNavigation groupIndex scoreComputer navigationAdverse Events After Total Hip Arthroplasty are not Sufficiently Characterized by 30-Day Follow-Up: A Database Study
Maloy GC, Kammien AJ, Rubin LE, Grauer JN. Adverse Events After Total Hip Arthroplasty are not Sufficiently Characterized by 30-Day Follow-Up: A Database Study. The Journal Of Arthroplasty 2022, 38: 525-529. PMID: 36272511, DOI: 10.1016/j.arth.2022.10.020.Peer-Reviewed Original ResearchConceptsTotal hip arthroplastyPostoperative adverse eventsAdverse eventsDay of surgeryHip arthroplastyDays of THAHigher Elixhauser-Comorbidity Index scoresElixhauser comorbidity index scoreComorbidity Index scoreLate adverse eventsTime of diagnosisPostoperative day 31THA patientsPredictive factorsPatient counselingPatient riskDatabase studyPrevention strategiesIndex scoreDay 31SurgeryInterquartile rangeAdministrative datasetsPatientsArthroplastyCorrelation of Patient Reported Satisfaction With Adverse Events Following Elective Posterior Lumbar Fusion Surgery: A Single Institution Analysis
Mercier MR, Galivanche AR, McLean R, Kammien AJ, Toombs CS, Rubio DR, Varthi AG, Grauer JN. Correlation of Patient Reported Satisfaction With Adverse Events Following Elective Posterior Lumbar Fusion Surgery: A Single Institution Analysis. North American Spine Society Journal (NASSJ) 2022, 12: 100160. PMID: 36118954, PMCID: PMC9478916, DOI: 10.1016/j.xnsj.2022.100160.Peer-Reviewed Original ResearchPosterior lumbar fusion surgeryLumbar fusion surgeryAdverse eventsHCAHPS surveyPLF surgeryFusion surgerySelf-reported patient satisfactionPostoperative adverse eventsRetrospective cohort analysisPost-discharge careSingle-institution analysisHospital Consumer AssessmentPatient satisfaction metricsCorrelation of patientsHCAHPS survey dataTop-box responsesPLF patientsSurvey response ratePatient satisfactionSingle institutionHospital experiencePatients' perceptionsHospital careCohort analysisPatientsSingle-level posterior lumbar fusions in patients with Ehlers Danlos Syndrome not found to be associated with increased postoperative adverse events or five-year reoperations
Gouzoulis MJ, Kammien AJ, Zhu JR, Gillinov SM, Moore HG, Grauer JN. Single-level posterior lumbar fusions in patients with Ehlers Danlos Syndrome not found to be associated with increased postoperative adverse events or five-year reoperations. North American Spine Society Journal (NASSJ) 2022, 11: 100136. PMID: 35783003, PMCID: PMC9241136, DOI: 10.1016/j.xnsj.2022.100136.Peer-Reviewed Original ResearchSingle-level posterior lumbar fusionPosterior lumbar fusionEhlers-Danlos syndromeMinor adverse eventsElixhauser Comorbidity IndexAdverse eventsEDS patientsAdult patientsLumbar fusionDanlos syndromeKaplan-Meier survival curvesRare connective tissue disorderPostoperative adverse eventsRate of reoperationRisk of complicationsNon-ED patientsLog-rank testConnective tissue disordersMultivariate logistical regressionSignificant differencesChi-square testPLF casesComorbidity indexReoperation rateRetrospective studyOutcomes Following Total Hip Arthroplasty in Patients With Postpolio Syndrome: A Matched Cohort Analysis
Mercier MR, Moore HG, Wolfstadt JI, Rubin LE, Grauer JN. Outcomes Following Total Hip Arthroplasty in Patients With Postpolio Syndrome: A Matched Cohort Analysis. The Journal Of Arthroplasty 2022, 37: 1822-1826. PMID: 35447277, DOI: 10.1016/j.arth.2022.04.016.Peer-Reviewed Original ResearchConceptsTotal hip arthroplastyPostpolio syndromeUrinary tract infectionPPS patientsControl patientsProsthetic dislocationTract infectionsRevision arthroplastyHip arthroplastyFive-year postoperative periodMatched Cohort AnalysisFive-year incidencePostoperative adverse eventsLong-term outcomesBasis of ageComorbidity burdenAdverse eventsPatient demographicsPostoperative periodPostoperative surveillanceHospital readmissionHip arthritisControl cohortAdministrative databasesCohort analysisUnicompartmental Knee Arthroplasty in Octogenarians: A National Database Analysis Including Over 700 Octogenarians
Moore HG, Schneble CA, Kahan JB, Grauer JN, Rubin LE. Unicompartmental Knee Arthroplasty in Octogenarians: A National Database Analysis Including Over 700 Octogenarians. Arthroplasty Today 2022, 15: 55-60. PMID: 35399988, PMCID: PMC8991237, DOI: 10.1016/j.artd.2022.02.009.Peer-Reviewed Original ResearchUnicompartmental knee arthroplastyAdverse eventsMedical comorbiditiesKnee arthroplastyNational Surgical Quality Improvement Program databaseLarge national surgical databaseQuality Improvement Program databaseHigher comorbidity burdenMinor adverse eventsPostoperative adverse eventsSerious adverse eventsImprovement Program databaseProlonged hospital stayUrinary tract infectionDay of surgeryNational database analysisNational surgical databaseShort-term mortalityMultivariate regression analysisComorbidity burdenOctogenarian cohortHospital lengthHospital stayNonhome dischargeSelect patientsJump in Elective Total Hip and Knee Arthroplasty Numbers at Age 65 Years: Evidence for Moral Hazard?
Rankin KA, Freedman IG, Moore HG, Halperin SJ, Rubin LE, Grauer JN. Jump in Elective Total Hip and Knee Arthroplasty Numbers at Age 65 Years: Evidence for Moral Hazard? JAAOS Global Research And Reviews 2022, 6: e22.00035. PMID: 35315795, PMCID: PMC8942773, DOI: 10.5435/jaaosglobal-d-22-00035.Peer-Reviewed Original ResearchConceptsTotal knee arthroplastyTotal hip arthroplastyAge 65 yearsNational Surgical Quality Improvement Program databaseIncidence of TKAElective total knee arthroplastyQuality Improvement Program databaseLower body mass indexElective total hipPostoperative adverse eventsPreoperative American SocietyImprovement Program databaseLower functional statusBody mass indexNon-Hispanic whitesNumber of proceduresAnesthesiologists classPreoperative characteristicsOlder patientsAdverse eventsTHA patientsMass indexTotal hipFunctional statusKnee arthroplastyUnderweight patients are the highest risk body mass index group for perioperative adverse events following stand-alone anterior lumbar interbody fusion
Ottesen TD, Galivanche AR, Greene JD, Malpani R, Varthi AG, Grauer JN. Underweight patients are the highest risk body mass index group for perioperative adverse events following stand-alone anterior lumbar interbody fusion. The Spine Journal 2022, 22: 1139-1148. PMID: 35231643, DOI: 10.1016/j.spinee.2022.02.012.Peer-Reviewed Original ResearchConceptsBody mass indexNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseAnterior lumbar interbody fusionObese class 1Improvement Program databaseClass 2 patientsAdverse eventsUnderweight patientsBMI categoriesAdverse outcomesBMI spectrumInterbody fusionProgram databaseTwo-level anterior lumbar interbody fusionSurgeons National Surgical Quality Improvement Program databaseMultivariate analysisThirty-day adverse eventsWorld Health Organization categoriesBody mass index groupsPostoperative adverse eventsRetrospective cohort studyPerioperative adverse eventsNormal-weight subjectsPost-operative infection
2021
COVID-positive ankle fracture patients are at increased odds of perioperative surgical complications following open reduction internal fixation surgery
Mercier MR, Galivanche AR, Brand JP, Pathak N, Medvecky MJ, Varthi AG, Rubin LE, Grauer JN. COVID-positive ankle fracture patients are at increased odds of perioperative surgical complications following open reduction internal fixation surgery. PLOS ONE 2021, 16: e0262115. PMID: 34972190, PMCID: PMC8719674, DOI: 10.1371/journal.pone.0262115.Peer-Reviewed Original ResearchConceptsCOVID-positive patientsAnkle fracture surgeryPerioperative adverse eventsAdverse eventsAnkle fracture patientsFracture surgeryFracture patientsOperative interventionAnkle fracturesPropensity matchingCOVID statusOpen reduction internal fixation surgeryPerioperative adverse outcomesPerioperative surgical complicationsMinor adverse eventsPostoperative adverse eventsSerious adverse eventsChronic kidney diseaseCOVID-19 Research DatabaseLong-term outcomesInternal fixation surgeryBasis of agePropensity-score matchingPostoperative complicationsNegative patientsRisk Factors for Venous Thromboembolism in Children Undergoing Orthopedic Surgery.
Mets EJ, Pathak N, Galivanche AR, McLynn RP, Frumberg DB, Grauer JN. Risk Factors for Venous Thromboembolism in Children Undergoing Orthopedic Surgery. Orthopedics 2021, 45: 31-37. PMID: 34846239, DOI: 10.3928/01477447-20211124-06.Peer-Reviewed Original ResearchConceptsVenous thromboembolismAdverse eventsRisk factorsOrthopedic surgeryNational Surgical Quality Improvement Program Pediatric databaseSurgeons National Surgical Quality Improvement Program Pediatric databaseIncidence of VTEPostoperative venous thromboembolismMinor adverse eventsPostoperative adverse eventsPreoperative blood transfusionIndependent risk factorMajor adverse eventsHigh-risk subpopulationsVTE prophylaxisPerioperative outcomesPatient demographicsBlood transfusionPatient factorsPediatric patientsSurgical variablesPreventable complicationsFemur fracturesPatient populationRetrospective analysisClinical Characteristics and Perioperative Complication Profiles of COVID-19–Positive Patients Undergoing Hip Fracture Surgery
Galivanche AR, Mercier MR, Schneble CA, Brand J, Pathak N, Varthi AG, Rubin LE, Grauer JN. Clinical Characteristics and Perioperative Complication Profiles of COVID-19–Positive Patients Undergoing Hip Fracture Surgery. JAAOS Global Research And Reviews 2021, 5: e21.00104. PMID: 34653097, PMCID: PMC8522872, DOI: 10.5435/jaaosglobal-d-21-00104.Peer-Reviewed Original ResearchConceptsHip fracture surgeryCOVID-19 positive patientsMinor adverse eventsAdverse eventsCOVID-19 positivityFracture surgeryHigh incidenceCOVID-19 positive groupCOVID-19 positive statusCOVID-19-negative groupGeriatric hip fracture surgeryPerioperative complication profilePostoperative adverse eventsHip fracture patientsSerious adverse eventsPatient risk factorsAdministrative claims dataCOVID-19 infectionAdverse event informationOngoing global pandemicClinical characteristicsFracture patientsPostoperative eventsPreoperative variablesPropensity matching