Molecular Markers in Maternal Blood Exosomes Allow Early Detection of Fetal Alcohol Spectrum Disorders
Darbinian N, Darbinyan A, Sinard J, Tatevosian G, Merabova N, D’Amico F, Khader T, Bajwa A, Martirosyan D, Gawlinski A, Pursnani R, Zhao H, Amini S, Morrison M, Goetzl L, Selzer M. Molecular Markers in Maternal Blood Exosomes Allow Early Detection of Fetal Alcohol Spectrum Disorders. International Journal Of Molecular Sciences 2022, 24: 135. PMID: 36613580, PMCID: PMC9820501, DOI: 10.3390/ijms24010135.Peer-Reviewed Original ResearchConceptsCaspase-3 activityBrain-derived exosomesMarker of synaptogenesisBrain caspase-3 activityFetal alcohol spectrum disordersMaternal blood samplesPrenatal alcohol exposureHuman fetal brainAlcohol spectrum disordersAvailable imaging techniquesMyelin basic proteinEtOH intakeEtOH exposureEtOH useMaternal raceNeurobehavioral deficitsAlcohol exposureMaternal bloodMother's bloodEarly diagnosisFetal brainBlood samplesMBP levelsTherapeutic interventionsBrain size