Whole-Exome Sequencing Enables a Precision Medicine Approach for Kidney Transplant Recipients
Mann N, Braun DA, Amann K, Tan W, Shril S, Connaughton DM, Nakayama M, Schneider R, Kitzler TM, van der Ven AT, Chen J, Ityel H, Vivante A, Majmundar AJ, Daga A, Warejko JK, Lovric S, Ashraf S, Jobst-Schwan T, Widmeier E, Hugo H, Mane SM, Spaneas L, Somers MJG, Ferguson MA, Traum AZ, Stein DR, Baum MA, Daouk GH, Lifton RP, Manzi S, Vakili K, Kim HB, Rodig NM, Hildebrandt F. Whole-Exome Sequencing Enables a Precision Medicine Approach for Kidney Transplant Recipients. Journal Of The American Society Of Nephrology 2019, 30: 201-215. PMID: 30655312, PMCID: PMC6362619, DOI: 10.1681/asn.2018060575.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBostonChildChild, PreschoolCohort StudiesExome SequencingFemaleGenetic Predisposition to DiseaseGenetic TestingGraft RejectionGraft SurvivalHospitals, PediatricHumansKidney TransplantationMalePrecision MedicinePrognosisRenal Insufficiency, ChronicRetrospective StudiesRisk AssessmentSeverity of Illness IndexSurvival AnalysisTransplant RecipientsTreatment OutcomeConceptsPediatric renal transplant recipientsWhole-exome sequencingKidney transplant recipientsRenal transplant recipientsTransplant recipientsDiagnostic yieldMolecular genetic diagnosisPediatric kidney transplant recipientsSteroid-resistant nephrotic syndromeGenetic causeBoston Children's HospitalUrinary stone diseasePrecision medicine approachYears of ageMolecular diagnosisGenetic diagnosisChronic glomerulonephritisTransplant patientsRelated donorsChildren's HospitalNephrotic syndromeKidney diseaseUnknown etiologyUrinary tractClinical management