2024
Is mild dehydration a risk for progression of childhood chronic kidney disease?
Le Page A, Johnson E, Greenberg J. Is mild dehydration a risk for progression of childhood chronic kidney disease? Pediatric Nephrology 2024, 39: 3177-3191. PMID: 38632124, PMCID: PMC11413076, DOI: 10.1007/s00467-024-06332-6.Peer-Reviewed Original ResearchChronic kidney diseaseChronic kidney disease aetiologyKidney diseaseGraphical abstractA higher resolution versionMild dehydrationRisk of CKD progressionConcentrating capacityChronic kidney disease populationFrequency of dehydrationChildhood chronic kidney diseaseImpact renal functionRisk of complicationsLow fluid intakeAssessment of dehydrationChronic kidney disease outcomesHyperfiltration injuryRandomised controlled trialsArginine vasopressinRenal functionCKD progressionFluid intakeTreatment planningAdequate hydrationRisk factorsControlled trials
2023
Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease
Sandokji I, Xu Y, Denburg M, Furth S, Abraham A, Greenberg J. Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease. Nephron 2023, 148: 1-10. PMID: 37232009, PMCID: PMC10840447, DOI: 10.1159/000530918.Peer-Reviewed Original ResearchChronic kidney diseaseCKD progressionKidney diseaseNovel biomarkersProgression of CKDLong-term adverse outcomesPediatric chronic kidney diseaseKidney function declineGlomerular filtration rateRisk of deathScreening studyCKD pathophysiologyFunction declineKidney biomarkersAdverse outcomesProgression riskFiltration rateClinical managementEarly recognitionClinical trialsPrognostic markerEarly diagnosisHigh riskClinical practicePromising biomarker
2021
Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children
Greenberg JH, Abraham AG, Xu Y, Schelling JR, Feldman HI, Sabbisetti VS, Ix JH, Jogalekar MP, Coca S, Waikar SS, Shlipak MG, Warady BA, Vasan RS, Kimmel PL, Bonventre JV, Denburg M, Parikh CR, Furth S, Consortium O. Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children. Journal Of The American Society Of Nephrology 2021, 32: 2664-2677. PMID: 34544821, PMCID: PMC8722795, DOI: 10.1681/asn.2021010094.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlbuminuriaAlpha-GlobulinsBiomarkersChemokine CCL2ChildChitinase-3-Like Protein 1CreatinineDisease ProgressionEpidermal Growth FactorFemaleFollow-Up StudiesGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansKidney TubulesMaleNephritisProspective StudiesRenal Insufficiency, ChronicConceptsUrine KIM-1CKD progressionUrine biomarkersMicroglobulin concentrationsHighest quartileKIM-1MCP-1High riskRapid kidney function declineBiomarker concentrationsEGF concentrationsKidney tubule healthNovel urine biomarkersUrine biomarker concentrationsKidney function declineProgression of CKDUrine creatinine concentrationIdentification of childrenTubular healthMultivariable adjustmentComposite outcomeTubular injuryPrimary outcomeFunction declineStudy enrollment