2023
Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome
Morand-Beaulieu S, Crowley M, Grantz H, Leckman J, Sukhodolsky D. Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome. Psychological Medicine 2023, 53: 7857-7864. PMID: 37485677, PMCID: PMC10755221, DOI: 10.1017/s0033291723001940.Peer-Reviewed Original ResearchConceptsVoluntary tic suppressionTic suppressionVocal tic severityFunctional connectivityTic severityTourette syndromeRight superior frontal gyrusFirst-line treatmentBehavior therapyComprehensive Behavioral InterventionSuperior frontal gyrusRight angular gyrusVocal ticsFunctional brain networksBehavioral interventionsUsual control conditionFrontal gyrusBaselineAngular gyrusSeverityBrain networksSyndromeChildrenTherapyGyrus
2020
Empiric Recurrence Risk Estimates for Chronic Tic Disorders: Implications for Genetic Counseling
Heiman GA, Rispoli J, Seymour C, Leckman JF, King RA, Fernandez TV. Empiric Recurrence Risk Estimates for Chronic Tic Disorders: Implications for Genetic Counseling. Frontiers In Neurology 2020, 11: 770. PMID: 32849224, PMCID: PMC7432137, DOI: 10.3389/fneur.2020.00770.Peer-Reviewed Original ResearchChronic tic disorderRecurrence risk estimatesTic disordersRecurrence riskTourette's disorderRisk estimatesNeuropsychiatric disordersPopulation-based family studyGenetic counselingFirst-degree relativesQuality of lifeFamily studiesVocal ticsPopulation prevalenceFamilial recurrence riskSuch counselingGenetic testingDisordersRiskCounselingEmpiric recurrence riskGenetic variantsRange of risksHeterogeneous genetic architectureComorbidities
2017
Tics and Tourette Syndrome
Sukhodolsky D, Gladstone T, Kaushal S, Piasecka J, Leckman J. Tics and Tourette Syndrome. Autism And Child Psychopathology Series 2017, 241-256. DOI: 10.1007/978-3-319-71210-9_14.ChaptersHabit reversal trainingTourette syndromeBehavioral interventionsPathophysiology of TSComprehensive clinical careComprehensive Behavioral InterventionCore clinical characteristicsAttention-deficit/hyperactivity disorderModerators of responseCo-occurring conditionsDisruptive behavior disordersClinical characteristicsChronic motorClinical efficacyTic expressionVocal ticsClinical recommendationsCo-occurring psychopathologyClinical careTic severityTreatment approachesPremonitory urgesBehavior disorderAnxiety disordersDiagnostic assessment
2016
The International Deep Brain Stimulation Registry and Database for Gilles de la Tourette Syndrome: How Does It Work?
Deeb W, Rossi PJ, Porta M, Visser-Vandewalle V, Servello D, Silburn P, Coyne T, Leckman JF, Foltynie T, Hariz M, Joyce EM, Zrinzo L, Kefalopoulou Z, Welter ML, Karachi C, Mallet L, Houeto JL, Shahed-Jimenez J, Meng FG, Klassen BT, Mogilner AY, Pourfar MH, Kuhn J, Ackermans L, Kaido T, Temel Y, Gross RE, Walker HC, Lozano AM, Khandhar SM, Walter BL, Walter E, Mari Z, Changizi BK, Moro E, Baldermann JC, Huys D, Zauber SE, Schrock LE, Zhang JG, Hu W, Foote KD, Rizer K, Mink JW, Woods DW, Gunduz A, Okun MS. The International Deep Brain Stimulation Registry and Database for Gilles de la Tourette Syndrome: How Does It Work? Frontiers In Neuroscience 2016, 10: 170. PMID: 27199634, PMCID: PMC4842757, DOI: 10.3389/fnins.2016.00170.Peer-Reviewed Original ResearchDeep brain stimulationTourette syndromeDBS centersSmall case seriesCombination of motorTourette AssociationCase seriesCase reportInternational registryBrain targetsMovement disordersVocal ticsRegulatory agency approvalParkinson's diseaseSevere casesBrain stimulationNeuropsychiatric diseasesRegistryBehavioral therapyGilles deT patientsDBS casesOverall small numberDiseaseAgency approval
2014
Tourette syndrome deep brain stimulation: A review and updated recommendations
Schrock LE, Mink JW, Woods DW, Porta M, Servello D, Visser‐Vandewalle V, Silburn PA, Foltynie T, Walker HC, Shahed‐Jimenez J, Savica R, Klassen BT, Machado AG, Foote KD, Zhang J, Hu W, Ackermans L, Temel Y, Mari Z, Changizi BK, Lozano A, Auyeung M, Kaido T, Agid Y, Welter ML, Khandhar SM, Mogilner AY, Pourfar MH, Walter BL, Juncos JL, Gross RE, Kuhn J, Leckman JF, Neimat JA, Okun MS, Group T. Tourette syndrome deep brain stimulation: A review and updated recommendations. Movement Disorders 2014, 30: 448-471. PMID: 25476818, DOI: 10.1002/mds.26094.Peer-Reviewed Original ResearchConceptsDeep brain stimulationTourette syndromeBrain stimulationBehavioral treatment trialsFifth Edition diagnosisPostoperative outcome measuresOptimal surgical approachMultidisciplinary team approachTourette syndrome patientsMultiple brain targetsYears of ageLocal ethics committeeInstitutional review boardDBS centersMedication refractoryUrgent indicationsSevere motorSurgical approachTreatment trialsBrain targetsEdition diagnosisVocal ticsSyndrome patientsOutcome measuresHigh riskClinical features of Tourette syndrome and tic disorders
Leckman JF, King RA, Bloch MH. Clinical features of Tourette syndrome and tic disorders. Journal Of Obsessive-Compulsive And Related Disorders 2014, 3: 372-379. PMID: 30197854, PMCID: PMC6124690, DOI: 10.1016/j.jocrd.2014.03.004.Peer-Reviewed Original ResearchTourette syndromeTic disordersLong-term clinical courseLong-term outcomesAge 10 yearsAttention deficit hyperactivity disorderCo-occurring conditionsClinical courseClinical featuresObsessive-compulsive disorderTic symptomsVisual-motor integrationVocal ticsPsychosocial stressMost childrenCourse of monthsLiterature searchRelevant articlesMotor integrationStereotyped movementsHyperactivity disorderEarly adulthoodDisordersNeurodevelopmental disordersSensory stimuli
2010
Tourette Syndrome in Children: An Updated Review
Du JC, Chiu TF, Lee KM, Wu HL, Yang YC, Hsu SY, Sun CS, Hwang B, Leckman JF. Tourette Syndrome in Children: An Updated Review. Pediatrics & Neonatology 2010, 51: 255-264. PMID: 20951354, DOI: 10.1016/s1875-9572(10)60050-2.Peer-Reviewed Original ResearchConceptsTourette syndromeVocal ticsMovement disordersBasal ganglia-related circuitsRepetitive transcranial magnetic stimulationPathophysiology of TSA2-adrenergic agonistHabit reversal therapySocial functioningTranscranial magnetic stimulationCommon neuropsychiatric disorderPatients' social functioningAttention deficit hyperactivity disorderDeficit hyperactivity disorderCommon comorbiditiesNeurological examinationStreptococcal infectionReversal therapyObsessive-compulsive disorderAtypical neurolepticsDopaminergic innervationCorrect diagnosisSevere casesMagnetic stimulationSensory urgeThe Immunobiology of Tourette's Disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus, and Related Disorders: A Way Forward
Murphy TK, Kurlan R, Leckman J. The Immunobiology of Tourette's Disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus, and Related Disorders: A Way Forward. Journal Of Child And Adolescent Psychopharmacology 2010, 20: 317-331. PMID: 20807070, PMCID: PMC4003464, DOI: 10.1089/cap.2010.0043.Peer-Reviewed Original ResearchConceptsGroup A StreptococcusObsessive-compulsive disorderSydenham's choreaTourette's disorderRheumatic feverNeuropsychiatric symptomsPediatric Autoimmune Neuropsychiatric Disorder AssociatedPediatric autoimmune neuropsychiatric disordersA StreptococcusCommon anatomic areasNeuropsychiatric Disorder AssociatedAutoimmune neuropsychiatric disordersAttention-deficit/hyperactivity symptomsImmune dysfunctionUnknown etiologyBasal gangliaChildhood obsessive-compulsive disorderSudden onsetDisorders AssociatedMotor ticsVocal ticsTherapeutic aspectsThalamic sitesReference listsAnatomic areasTic disorders: some key issues for DSM‐V
Walkup JT, Ferrão Y, Leckman JF, Stein DJ, Singer H. Tic disorders: some key issues for DSM‐V. Depression And Anxiety 2010, 27: 600-610. PMID: 20533370, DOI: 10.1002/da.20711.Peer-Reviewed Original Research
2009
Clinical course of Tourette syndrome
Bloch MH, Leckman JF. Clinical course of Tourette syndrome. Journal Of Psychosomatic Research 2009, 67: 497-501. PMID: 19913654, PMCID: PMC3974606, DOI: 10.1016/j.jpsychores.2009.09.002.Peer-Reviewed Original ResearchConceptsTourette syndromeComorbid conditionsObsessive-compulsive disorderClinical courseLong-term clinical courseChildhood-onset neuropsychiatric disorderEarly adulthoodLong-term outcomesAttention deficit disorderTic symptomsDepressive disorderTic disordersVocal ticsGeneral populationNeuropsychiatric disordersLiterature searchRelevant articlesDisordersSyndromeChildrenAdulthood outcomesOne-thirdSymptomsTraditional literature searchThree-quarters
2006
Tourette Syndrome: The Self Under Siege
Leckman JF, Bloch MH, Scahill L, King RA. Tourette Syndrome: The Self Under Siege. Journal Of Child Neurology 2006, 21: 642-649. PMID: 16970864, DOI: 10.1177/08830738060210081001.Peer-Reviewed Original ResearchConceptsTourette syndromeAttention deficit hyperactivity disorderSensorimotor gatingSimple motor ticsYears of ageAge 10 yearsPostmortem brain studiesVivo brain imagingObsessive-compulsive disorderPrepubertal onsetVisual-motor integrationElectrophysiologic recordingsMotor ticsVocal ticsTic severityFine motorMost childrenNatural historySyndromeBehavioral treatmentMotor responseCourse of monthsNeural circuitryMotor integrationStereotyped movements
2005
Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome
Kalanithi PS, Zheng W, Kataoka Y, DiFiglia M, Grantz H, Saper CB, Schwartz ML, Leckman JF, Vaccarino FM. Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 13307-13312. PMID: 16131542, PMCID: PMC1201574, DOI: 10.1073/pnas.0502624102.Peer-Reviewed Original ResearchConceptsTourette syndromeNeuron distributionCalcium-binding protein parvalbuminNeuron numberT subjectsLower neuron numberGlobus pallidus pars externaParvalbumin-positive interneuronsTotal neuron numberUnbiased stereological techniquesChildhood neuropsychiatric disordersBasal ganglia tissueGABAergic neuronsGPi neuronsBasal gangliaCortico-striatoGlobus pallidusProtein parvalbuminThalamic circuitryGanglion tissueVocal ticsNormal controlsPutamen volumePars externaImaging studiesPublic health significance of tic disorders in children and adolescents.
Scahill L, Sukhodolsky DG, Williams SK, Leckman JF. Public health significance of tic disorders in children and adolescents. Advances In Neurology 2005, 96: 240-8. PMID: 16383223.Peer-Reviewed Original ResearchConceptsTic disordersPresence of ADHDAbsence of ADHDPublic health significanceCommunity sampleMild ticsPersistent ticsGreater disabilityVocal ticsDaily livingDisruptive behaviorChronic ticsHealth significanceDisordersClinical samplesCommunity surveyChildrenADHDMinimal consequencesMultiple motorsImpairment
1992
Sensory phenomena associated with Gilles de la Tourette's syndrome.
Cohen AJ, Leckman JF. Sensory phenomena associated with Gilles de la Tourette's syndrome. The Journal Of Clinical Psychiatry 1992, 53: 319-23. PMID: 1517194.Peer-Reviewed Original ResearchConceptsPremonitory urgesSyndrome AssociationPatient listsSensory phenomenaGilles de la Tourette's syndromeTourette Syndrome AssociationLa Tourette's syndromePhonic ticsVocal ticsTourette syndromeTS sufferersSyndromeVisual stimuliSubjectsSensitizationSufferersParticipantsTelephonePatientsUrgeCliniciansStudy