Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making
Oemisch M, Seo H. Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making. ELife 2024, 12: rp87529. PMID: 38700991, PMCID: PMC11068354, DOI: 10.7554/elife.87529.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntranasalAnimalsAntidepressive AgentsBehavior, AnimalDecision MakingInjections, IntramuscularKetamineMacaca mulattaMaleConceptsDose of ketamineAntidepressant effectsKetamine's antidepressant actionPotential antidepressant effectsRapid-acting antidepressantsPathophysiology of depressionImpact of negative eventsAntidepressant actionBehavioral perseverationAversive effectsNeuropsychological changesTreating depressionAffect memoryMood statesNegative eventsAdaptive behaviorSynaptic levelAffective eventsTemporal credit assignmentTherapeutic dosesDepressionCognitive aspectsInhibitory circuitryBehavioral changesAcute effects