Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making
Oemisch M, Seo H. Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making. ELife 2024, 12 DOI: 10.7554/elife.87529.3.Peer-Reviewed Original ResearchPotential antidepressant effectsDose of ketamineAntidepressant effectsKetamine's antidepressant actionRapid-acting antidepressantsPathophysiology of depressionImpact of negative eventsAntidepressant actionBehavioral perseverationAversive effectsNeuropsychological changesTreating depressionAffect memoryMood statesNegative eventsAdaptive behaviorSynaptic levelAffective eventsTemporal credit assignmentTherapeutic dosesDepressionCognitive aspectsInhibitory circuitryBehavioral changesAcute effectsTherapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making
Oemisch M, Seo H. Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making. ELife 2024, 12: rp87529. PMID: 38700991, PMCID: PMC11068354, DOI: 10.7554/elife.87529.Peer-Reviewed Original ResearchConceptsDose of ketamineAntidepressant effectsKetamine's antidepressant actionPotential antidepressant effectsRapid-acting antidepressantsPathophysiology of depressionImpact of negative eventsAntidepressant actionBehavioral perseverationAversive effectsNeuropsychological changesTreating depressionAffect memoryMood statesNegative eventsAdaptive behaviorSynaptic levelAffective eventsTemporal credit assignmentTherapeutic dosesDepressionCognitive aspectsInhibitory circuitryBehavioral changesAcute effects