A nucleoid-associated protein is involved in the emergence of antibiotic resistance by promoting the frequent exchange of the replicative DNA polymerase in Mycobacterium smegmatis
Ng W, Rego E. A nucleoid-associated protein is involved in the emergence of antibiotic resistance by promoting the frequent exchange of the replicative DNA polymerase in Mycobacterium smegmatis. MSphere 2024, 9: e00122-24. PMID: 38591887, PMCID: PMC11237743, DOI: 10.1128/msphere.00122-24.Peer-Reviewed Original ResearchNucleoid-associated proteinsReplicative DNA polymerasesBypass DNA lesionsDNA replicationDNA polymeraseAntibiotic resistanceDamaged DNAExpression of error-prone DNA polymerasesReplicative polymerasesHigh-fidelity replicative polymerasesQuantitative fluorescence imaging techniqueError-prone DNA synthesisDNA lesionsError-prone DNA polymerasesHorizontal gene transferEmergence of antibiotic resistanceDNA-damaging agentsRepair damaged DNAResistance to rifampinRobust cell growthGrowth defectLsr2Replication forksBacterial speciesChromosomal mutations