Bimodal Influence of Vitamin D in Host Response to Systemic Candida Infection—Vitamin D Dose Matters
Lim JH, Ravikumar S, Wang YM, Thamboo TP, Ong L, Chen J, Goh JG, Tay SH, Chengchen L, Win MS, Leong W, Lau T, Foo R, Mirza H, Tan KS, Sethi S, Khoo AL, Chng WJ, Osato M, Netea MG, Wang Y, Chai LY. Bimodal Influence of Vitamin D in Host Response to Systemic Candida Infection—Vitamin D Dose Matters. The Journal Of Infectious Diseases 2015, 212: 635-644. PMID: 25612733, DOI: 10.1093/infdis/jiv033.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCandidiasisCholecalciferolCohort StudiesDose-Response Relationship, DrugGene Expression RegulationHumansInflammationInterferon-gammaLeukocytes, MononuclearMiceMice, Inbred BALB CPromoter Regions, GeneticRNA, MessengerSTAT Transcription FactorsSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling ProteinsVitamin DConceptsVitamin D levelsCandida infectionsVitamin DD levelsVitamin D3 dosesVitamin D3 supplementationProinflammatory immune responseSystemic Candida infectionSuppression of SOCS3Vitamin D receptorVitamin D response elementD response elementCandidemic patientsD3 supplementationUntreated micePoor outcomeAntiinflammatory effectsFungal burdenVitamin D3Immune responseInterferon γD receptorBetter survivalDose matterBimodal influence