2024
A confounder controlled machine learning approach: Group analysis and classification of schizophrenia and Alzheimer’s disease using resting-state functional network connectivity
Hassanzadeh R, Abrol A, Pearlson G, Turner J, Calhoun V. A confounder controlled machine learning approach: Group analysis and classification of schizophrenia and Alzheimer’s disease using resting-state functional network connectivity. PLOS ONE 2024, 19: e0293053. PMID: 38768123, PMCID: PMC11104643, DOI: 10.1371/journal.pone.0293053.Peer-Reviewed Original ResearchConceptsResting-state functional network connectivityFunctional network connectivityResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingAlzheimer's diseaseClassification of schizophreniaNetwork pairsPatients to healthy controlsSchizophrenia patientsNeurobiological mechanismsSZ patientsSubcortical networksCerebellum networkSchizophreniaRs-fMRIDisorder developmentMotor networkCompare patient groupsSubcortical domainSZ disorderHealthy controlsMagnetic resonance imagingDisordersNetwork connectivityFunctional abnormalitiesMore reliable biomarkers and more accurate prediction for mental disorders using a label-noise filtering-based dimensional prediction method
Xing Y, van Erp T, Pearlson G, Kochunov P, Calhoun V, Du Y. More reliable biomarkers and more accurate prediction for mental disorders using a label-noise filtering-based dimensional prediction method. IScience 2024, 27: 109319. PMID: 38482500, PMCID: PMC10933544, DOI: 10.1016/j.isci.2024.109319.Peer-Reviewed Original ResearchDiagnosis of mental disordersMental disordersDiagnostic labelsIntegration of neuroimagingSchizophrenia patientsNeuroimaging measuresNeuroimaging perspectiveFMRI dataStable abnormalitiesNeuroimagingDisordersHealthy controlsIndependent subjectsSchizophreniaFMRIDimensional predictionsSubjectsAccurate diagnosisClassification accuracy
2020
Functional MRI Findings in Schizophrenia
Pearlson G. Functional MRI Findings in Schizophrenia. 2020, 113-124. DOI: 10.1007/978-3-030-35206-6_6.Peer-Reviewed Original ResearchSchizophrenia patientsDrug-naïve patientsFunctional MRI findingsFunctional MRI literatureTask-related paradigmsMRI findingsMedication treatmentPredisposing causeHealthy controlsFunctional abnormalitiesMRI reportsPsychotic bipolarNeurodevelopmental anomaliesPatientsBrain differencesUnaffected relativesSynaptic efficiencySchizophreniaMRI literatureAbnormalitiesArticle reviewsLocal manifestationsReviewSymptomsNeurotransmitters
2017
Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
Kelly S, Jahanshad N, Zalesky A, Kochunov P, Agartz I, Alloza C, Andreassen O, Arango C, Banaj N, Bouix S, Bousman C, Brouwer R, Bruggemann J, Bustillo J, Cahn W, Calhoun V, Cannon D, Carr V, Catts S, Chen J, Chen J, Chen X, Chiapponi C, Cho K, Ciullo V, Corvin A, Crespo-Facorro B, Cropley V, De Rossi P, Diaz-Caneja C, Dickie E, Ehrlich S, Fan F, Faskowitz J, Fatouros-Bergman H, Flyckt L, Ford J, Fouche J, Fukunaga M, Gill M, Glahn D, Gollub R, Goudzwaard E, Guo H, Gur R, Gur R, Gurholt T, Hashimoto R, Hatton S, Henskens F, Hibar D, Hickie I, Hong L, Horacek J, Howells F, Hulshoff Pol H, Hyde C, Isaev D, Jablensky A, Jansen P, Janssen J, Jönsson E, Jung L, Kahn R, Kikinis Z, Liu K, Klauser P, Knöchel C, Kubicki M, Lagopoulos J, Langen C, Lawrie S, Lenroot R, Lim K, Lopez-Jaramillo C, Lyall A, Magnotta V, Mandl R, Mathalon D, McCarley R, McCarthy-Jones S, McDonald C, McEwen S, McIntosh A, Melicher T, Mesholam-Gately R, Michie P, Mowry B, Mueller B, Newell D, O'Donnell P, Oertel-Knöchel V, Oestreich L, Paciga S, Pantelis C, Pasternak O, Pearlson G, Pellicano G, Pereira A, Pineda Zapata J, Piras F, Potkin S, Preda A, Rasser P, Roalf D, Roiz R, Roos A, Rotenberg D, Satterthwaite T, Savadjiev P, Schall U, Scott R, Seal M, Seidman L, Shannon Weickert C, Whelan C, Shenton M, Kwon J, Spalletta G, Spaniel F, Sprooten E, Stäblein M, Stein D, Sundram S, Tan Y, Tan S, Tang S, Temmingh H, Westlye L, Tønnesen S, Tordesillas-Gutierrez D, Doan N, Vaidya J, van Haren N, Vargas C, Vecchio D, Velakoulis D, Voineskos A, Voyvodic J, Wang Z, Wan P, Wei D, Weickert T, Whalley H, White T, Whitford T, Wojcik J, Xiang H, Xie Z, Yamamori H, Yang F, Yao N, Zhang G, Zhao J, van Erp T, Turner J, Thompson P, Donohoe G. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group. Molecular Psychiatry 2017, 23: 1261-1269. PMID: 29038599, PMCID: PMC5984078, DOI: 10.1038/mp.2017.170.Peer-Reviewed Original ResearchConceptsSchizophrenia patientsFractional anisotropyWM skeletonWhite matter microstructural differencesWhite matter abnormalitiesWidespread WM abnormalitiesOnset of schizophreniaAnterior corona radiataEffect sizeDiffusion tensor imaging (DTI) dataTensor imaging dataHealthy controlsMeta-analyzed effectsCorpus callosumMedication dosageCorona radiataPsychiatric disordersLarge effect sizesWM microstructural differencesPatientsWM abnormalitiesRadial diffusivitySchizophreniaSignificant decreaseDiffusivity measures
2010
Aberrant processing of deviant stimuli in schizophrenia revealed by fusion of fMRI and EEG data
Calhoun V, Wu L, Kiehl K, Eichele T, Pearlson G. Aberrant processing of deviant stimuli in schizophrenia revealed by fusion of fMRI and EEG data. Acta Neuropsychiatrica 2010, 22: 127-138. PMID: 21331320, PMCID: PMC3038634, DOI: 10.1111/j.1601-5215.2010.00467.x.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingChronic schizophrenia patientsSchizophrenia patientsJoint independent component analysisHealthy control subjectsFronto-temporal regionsMagnetic resonance imagingLatency abnormalitiesDeviant stimuliControl subjectsHealthy controlsHemodynamic differencesPatientsBipolar disorderAlzheimer's diseaseResonance imagingAuditory oddball stimuliDiseaseSchizophreniaGroup differencesOddball stimuliN2 responseElectrical changesAberrant processingN2 amplitude
2009
Functional connectivity differences in first episode and chronic schizophrenia patients during an auditory sensorimotor task revealed by independent component analysis of a large multisite study
Juárez M, White T, Pearlson G, Bustillo J, Lauriello J, Ho B, Bockholt H, Clark V, Gollub R, Magnotta V, Machado G, Calhoun V. Functional connectivity differences in first episode and chronic schizophrenia patients during an auditory sensorimotor task revealed by independent component analysis of a large multisite study. NeuroImage 2009, 47: s158. DOI: 10.1016/s1053-8119(09)71664-7.Peer-Reviewed Original Research