2024
Gyrification across psychotic disorders: A bipolar-schizophrenia network of intermediate phenotypes study
Rychagov N, Del Re E, Zeng V, Oykhman E, Lizano P, McDowell J, Yassin W, Clementz B, Gershon E, Pearlson G, Sweeney J, Tamminga C, Keshavan M. Gyrification across psychotic disorders: A bipolar-schizophrenia network of intermediate phenotypes study. Schizophrenia Research 2024, 271: 169-178. PMID: 39032429, PMCID: PMC11384321, DOI: 10.1016/j.schres.2024.07.009.Peer-Reviewed Original ResearchBipolar-Schizophrenia NetworkPsychotic disordersDSM-IVIntermediate Phenotypes studyGyrification changesSchizophrenia compared to controlsBipolar I disorderRight cingulate cortexSchizoaffective disorder probandsBipolar disorder probandsDisorders compared to controlsAge-related differencesSchizoaffective disorderCingulate cortexVerbal memoryBipolar disorderAge-related changesFalse discovery rate correctionSchizophreniaCortical gyrificationHypogyriaFrontal lobeGyrificationDisordersHealthy controls
2023
Identifying psychosis subtypes use individualized covariance structural differential networks and multi-site clustering
Ji Y, Pearlson G, Bustillo J, Kochunov P, Turner J, Jiang R, Shao W, Zhang X, Fu Z, Li K, Liu Z, Xu X, Zhang D, Qi S, Calhoun V. Identifying psychosis subtypes use individualized covariance structural differential networks and multi-site clustering. Schizophrenia Research 2023, 264: 130-139. PMID: 38128344, DOI: 10.1016/j.schres.2023.12.013.Peer-Reviewed Original ResearchPsychosis subtypesSchizoaffective disorderBipolar disorderClinical phenotypeFirst-degree relativesTemporal-occipital cortexAmygdala-hippocampusClinical symptomsNeuroimaging featuresBipolar-Schizophrenia NetworkBrain alterationsHealthy controlsIntermediate Phenotypes (B-SNIP) consortiumOccipital cortexDecreased connectivitySubtypesStructural covarianceFractional amplitudeSubtype IILow-frequency fluctuationsNeurobiological heterogeneityGreater predispositionPsychosis spectrumGroup differencesDiagnostic classificationCharacterization of childhood trauma, hippocampal mediation and Cannabis use in a large dataset of psychosis and non-psychosis individuals
Del Re E, Yassin W, Zeng V, Keedy S, Alliey-Rodriguez N, Ivleva E, Hill S, Rychagov N, McDowell J, Bishop J, Mesholam-Gately R, Merola G, Lizano P, Gershon E, Pearlson G, Sweeney J, Clementz B, Tamminga C, Keshavan M. Characterization of childhood trauma, hippocampal mediation and Cannabis use in a large dataset of psychosis and non-psychosis individuals. Schizophrenia Research 2023, 255: 102-109. PMID: 36989667, DOI: 10.1016/j.schres.2023.03.029.Peer-Reviewed Original ResearchConceptsChildhood Trauma QuestionnaireChildhood traumaPsychosis onsetBipolar disorder type 1Rich brain regionsAbuse/dependenceHigh childhood traumaSevere childhood traumaPolygenic risk scoresRisk scoreClinical interviewersSchizoaffective disorderMulticenter sampleSurvival analysisCA exposureYounger ageBrain regionsType 1Psychosis riskLower ageCeiling effectsHippocampusTrauma QuestionnaireSZ-polygenic risk scoreGenetic risk
2022
Multimodal data fusion of cortical-subcortical morphology and functional network connectivity in psychotic spectrum disorder
DeRamus T, Wu L, Qi S, Iraji A, Silva R, Du Y, Pearlson G, Mayer A, Bustillo J, Stromberg S, Calhoun V. Multimodal data fusion of cortical-subcortical morphology and functional network connectivity in psychotic spectrum disorder. NeuroImage Clinical 2022, 35: 103056. PMID: 35709557, PMCID: PMC9207350, DOI: 10.1016/j.nicl.2022.103056.Peer-Reviewed Original ResearchConceptsResting-state functional network connectivityFunctional network connectivityGray matterFractional anisotropyMultimodal canonical correlation analysisSchizoaffective disorderBipolar disorderJoint independent component analysisDiagnostic categoriesFunctional brain featuresWhite matter fractional anisotropyBrain featuresPsychotic spectrum disordersClinical indicatorsMultiple diagnostic categoriesFunctional alterationsSubcortical structuresDisordersP523. Comparison of Lifetime Psychosis and Mood Symptoms in Schizophrenia, Schizoaffective Disorder, and Bipolar Disorder With Psychotic Features
Church H, Khera I, Kern B, Pearlson G, Clementz B, McDowell J, Keshavan M, Tamminga C, Ivleva E, Gershon E, Keedy S. P523. Comparison of Lifetime Psychosis and Mood Symptoms in Schizophrenia, Schizoaffective Disorder, and Bipolar Disorder With Psychotic Features. Biological Psychiatry 2022, 91: s300. DOI: 10.1016/j.biopsych.2022.02.760.Peer-Reviewed Original Research
2021
Anterior-posterior axis of hippocampal subfields across psychoses: A B-SNIP study
del Re E, Zeng V, Alliey-Rodriguez N, Lizano P, Bolo N, Lutz O, Pearlson G, Sweeney J, Clementz B, Gershon E, Tamminga C, Keshavan M. Anterior-posterior axis of hippocampal subfields across psychoses: A B-SNIP study. Biomarkers In Neuropsychiatry 2021, 5: 100037. DOI: 10.1016/j.bionps.2021.100037.Peer-Reviewed Original ResearchVolumetric abnormalitiesPsychosis probandsBipolar type 1Granule cell layerT MRI scansB-SNIP studyB-SNIPDentate gyrusBipolar-Schizophrenia NetworkHealthy controlsClinical dataHippocampal subfieldsDSM categoriesMRI scansSchizoaffective disorderHippocampusType 1Schizophrenia NetworkAbnormalitiesUnaffected relativesAnterior-posterior axisSchizophreniaPsychosisProbandsConclusions Differences
2020
Auditory paired-stimuli responses across the psychosis and bipolar spectrum and their relationship to clinical features
Parker D, Trotti R, McDowell J, Keedy S, Gershon E, Ivleva E, Pearlson G, Keshavan M, Tamminga C, Sweeney J, Clementz B. Auditory paired-stimuli responses across the psychosis and bipolar spectrum and their relationship to clinical features. Biomarkers In Neuropsychiatry 2020, 3: 100014. PMID: 36644018, PMCID: PMC9837793, DOI: 10.1016/j.bionps.2020.100014.Peer-Reviewed Original ResearchSchizoaffective disorderGroup differencesBipolar disorderAuditory paired-stimulus paradigmPaired-stimulus paradigmNeural responsesIdentification of biomarkersB-SNIPClinical featuresSignificant group differencesPsychosis subjectsBipolar-Schizophrenia NetworkPsychosis casesHealthy subjectsPreparatory periodPsychosis syndromeFrequency principal components analysisMania symptomsP50 responsePositive symptomsClinical phenotypeAffective syndromeBipolar spectrumPsychosisPutative biomarkers
2018
T22. PITUITARY GLAND VOLUME DIFFERENCES IN INDIVIDUALS WITH PSYCHOSIS: RESULTS FROM THE BIPOLAR-SCHIZOPHRENIA NETWORK ON INTERMEDIATE PHENOTYPES (B-SNIP) STUDY
Guimond S, Tingue S, Devenyi G, Tang Y, Mike L, Chakravarty M, Sweeney J, Pearlson G, Clementz B, Tamminga C, Keshavan M. T22. PITUITARY GLAND VOLUME DIFFERENCES IN INDIVIDUALS WITH PSYCHOSIS: RESULTS FROM THE BIPOLAR-SCHIZOPHRENIA NETWORK ON INTERMEDIATE PHENOTYPES (B-SNIP) STUDY. Schizophrenia Bulletin 2018, 44: s121-s121. PMCID: PMC5888564, DOI: 10.1093/schbul/sby016.298.Peer-Reviewed Original ResearchPituitary gland volumeLarger pituitary glandsDuration of illnessHealthy controlsGland volumePituitary glandPsychotic bipolar disorderSymptom severityBipolar-Schizophrenia NetworkPituitary volumeSchizoaffective disorderLarger pituitary gland volumesClinical diagnosisLarger pituitary volumeSubgroup of patientsSignificant main effectGreater symptom severitySignificant subgroup differencesIndependent t-testAdrenal axisPatient groupIntermediate Phenotypes (B-SNIP) consortiumMAGeT Brain algorithmStructural magnetic resonance imagesIntermediate Phenotypes (B-SNIP) study
2015
Identifying Brain Dynamic Network States VIA GIG-ICA: Application to Schizophrenia, Bipolar and Schizoaffective Disorders
Du Y, Pearlson G, He H, Wu L, Chen J, Calhoun V. Identifying Brain Dynamic Network States VIA GIG-ICA: Application to Schizophrenia, Bipolar and Schizoaffective Disorders. 2015, 478-481. DOI: 10.1109/isbi.2015.7163915.Peer-Reviewed Original ResearchFunctional connectivity statesSchizoaffective disorderBipolar disorderSAD patientsDynamic functional networksFunctional networksConnectivity statesResting-state fMRI dataBP patientsHealthy controlsPatientsSZ patientsFunctional connectivitySimilar symptomsFMRI dataDisordersSchizophreniaMental diseasesSignificant differences