2024
Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis
Meyhoefer I, Sprenger A, Derad D, Grotegerd D, Leenings R, Leehr E, Breuer F, Surmann M, Rolfes K, Arolt V, Romer G, Lappe M, Rehder J, Koutsouleris N, Borgwardt S, Schultze-Lutter F, Meisenzahl E, Kircher T, Keedy S, Bishop J, Ivleva E, McDowell J, Reilly J, Hill S, Pearlson G, Tamminga C, Keshavan M, Gershon E, Clementz B, Sweeney J, Hahn T, Dannlowski U, Lencer R. Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis. Scientific Reports 2024, 14: 13859. PMID: 38879556, PMCID: PMC11180169, DOI: 10.1038/s41598-024-64487-6.Peer-Reviewed Original ResearchConceptsSmooth pursuit eye movementsPsychosis syndromePursuit eye movementsNon-psychotic bipolar disorderNon-psychotic affective disorderEye movementsSmooth pursuit dysfunctionMultivariate pattern analysisHealthy controlsPsychiatric sampleNeurobiological markersPsychosis probandsPsychotic syndromesAffective disordersPsychosis researchBipolar disorderPsychosis statusPsychosisSensorimotor functionSensorimotor measuresIndividual levelSensorimotor dysfunctionSensorimotorDisordersPattern analysis
2017
Genome-Wide Association Studies Of Smooth Pursuit Eye Movements Across Psychotic Disorders: Preliminary Findings From The B-Snip Sample
Lencer R, Mills L, Alliey-Rodriguez N, Reilly J, Sprenger A, McDowell J, Keshavan M, Pearlson G, McCarroll S, Tamminga C, Clementz B, Gershon E, Sweeney J, Bishop J. Genome-Wide Association Studies Of Smooth Pursuit Eye Movements Across Psychotic Disorders: Preliminary Findings From The B-Snip Sample. European Neuropsychopharmacology 2017, 27: s489. DOI: 10.1016/j.euroneuro.2016.09.580.Peer-Reviewed Original ResearchPursuit maintenancePsychotic disordersSmooth pursuit eye movementsSensorimotor processingEye movement dysfunctionSignificant neurological disordersSevere mental illnessRecent substance abusePursuit eye movementsYears of ageFunctional brain systemsPursuit deficitSensorimotor deficitsPursuit initiationBipolar-Schizophrenia NetworkPsychosis probandsEye accelerationMovement dysfunctionInterhemispheric connectionsIntermediate Phenotypes (B-SNIP) studyNeurophysiological consequencesPrimary analysisBipolar disorderMental illnessNeurological disorders