2024
Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis
Barsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina D, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.Peer-Reviewed Original ResearchMinimal change diseaseRandomized controlled trialsSafety of metforminDouble-blindPodocyte injuryAdjunctive therapyPlacebo-controlled randomized controlled trialsPhase III studyPhase II trialPrimary glomerular diseaseFocal segmental glomerulosclerosisEffect of metforminPhase IIPlacebo-controlledPreclinical dataNovel urineChange diseaseTissue markersRandomized trialsSegmental glomerulosclerosisGlomerular diseaseMechanistic biomarkersObservational studyFSGSInexpensive agent
2014
Quantification and localization of M2 macrophages in human kidneys with acute tubular injury
Palmer MB, Vichot AA, Cantley LG, Moeckel GW. Quantification and localization of M2 macrophages in human kidneys with acute tubular injury. International Journal Of Nephrology And Renovascular Disease 2014, Volume 7: 415-419. PMID: 25404860, PMCID: PMC4230184, DOI: 10.2147/ijnrd.s66936.Peer-Reviewed Original ResearchAcute tubular injuryMinimal change diseaseM2 macrophagesTubular epithelial cellsTubular injuryMacrophage populationsEpithelial cellsBiopsy-proven diagnosisUltra-structural examinationProximal tubule cellsTubular basement membraneBasement membraneHuman kidney sectionsHuman kidney tissueHLA-DRChange diseaseAbove diagnosisInterstitial macrophagesM1 macrophagesM2 phenotypeInterstitial macrophage populationKidney sectionsKidney tissuePatientsTubule cells