2023
MicroRNA-1 protects the endothelium in acute lung injury
Korde A, Haslip M, Pednekar P, Khan A, Chioccioli M, Mehta S, Lopez-Giraldez F, Bermejo S, Rojas M, Dela Cruz C, Matthay M, Pober J, Pierce R, Takyar S. MicroRNA-1 protects the endothelium in acute lung injury. JCI Insight 2023, 8: e164816. PMID: 37737266, PMCID: PMC10561733, DOI: 10.1172/jci.insight.164816.Peer-Reviewed Original ResearchMeSH KeywordsAcute Lung InjuryAnimalsEndotheliumHumansMiceMicroRNAsRespiratory Distress SyndromeVascular Endothelial Growth Factor AConceptsAcute respiratory distress syndromeAcute lung injuryVascular endothelial growth factorAngiopoietin-2Lung injuryAcute injuryMiR-1MicroRNA-1Endothelial cell-specific overexpressionSevere endothelial dysfunctionRespiratory distress syndromeSurvival of miceIntrinsic protective effectContext of injuryCell-specific overexpressionEndothelial growth factorFamily member 3Pneumonia cohortMiR-1 targetsEndothelial dysfunctionDistress syndromeBarrier dysfunctionCapillary leakProtective effectSevere form
2022
Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A
Mantsounga CS, Lee C, Neverson J, Sharma S, Healy A, Berus JM, Parry C, Ceneri NM, López-Giráldez F, Chun HJ, Lu Q, Sellke F, Choudhary G, Morrison AR. Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A. Cell Reports 2022, 38: 110309. PMID: 35108537, PMCID: PMC8865931, DOI: 10.1016/j.celrep.2022.110309.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCytokinesDNA-Binding ProteinsInterleukin-1betaMacrophagesMice, TransgenicNF-kappa BPromoter Regions, GeneticSTAT3 Transcription FactorTrans-ActivatorsVascular Endothelial Growth Factor AConceptsPeripheral artery diseaseIL-1βPro-angiogenic VEGFNF-κBSetting of PADExperimental PAD modelInflammatory macrophage subsetsAcute limb ischemiaBlood flow recoveryIL-1β expressionNF-κB-mediated transcriptionPotent inflammatory cytokineMacrophage IL-1βAnti-angiogenic VEGFLimb ischemiaArtery diseaseConsiderable morbidityInhibition of STAT3Inflammatory cytokinesMacrophage subsetsTherapeutic angiogenesisFlow recoveryVEGFIsoform expressionAngiogenesis