2025
Chapter 53 Tourette syndrome
Abdallah S, Fasching L, Brady M, Bloch M, Lombroso P, Vaccarino F, Fernandez T. Chapter 53 Tourette syndrome. 2025, 951-962. DOI: 10.1016/b978-0-443-19176-3.00044-3.Peer-Reviewed Original ResearchTourette syndromeCortico-striatal-thalamo-cortical circuitryStriatal volume lossAdult TS patientsNeuroimaging studiesNeuropsychiatric disordersDopaminergic receptorsVocal ticsStriatal interneuronsClasses of striatal interneuronsBasal gangliaMetabolic hypofunctionEnvironmental risk factorsTS patientsAmeliorate symptomsGenetic contributionMolecular abnormalitiesPharmacological strategiesCircuitryAffecting 1Animal modelsRisk factorsInterneuronal circuitryVolume lossAbnormalities
2023
Early Neuronal Differentiation/patterning of the Human Pallium, Modeling by in Vitro Systems, and Disruption in Developmental Disorders
Scuderi S, Jourdon A, Vaccarino F. Early Neuronal Differentiation/patterning of the Human Pallium, Modeling by in Vitro Systems, and Disruption in Developmental Disorders. 2023, 423-442. DOI: 10.1002/9781119860914.ch20.Peer-Reviewed Original ResearchCentral nervous systemDorsal-anterior partHuman cortexCortical developmentInhibitory neuronsSingle-cell omicsAnimal modelsNervous systemCortical layersMammalian brainBrain regionsCortical formationPopulations of excitatoryTangential migrationAltered developmentCortical structuresAnterior partCortical patterningPrecursor cellsEarly neuronal differentiationIncoming afferentsCortexNeuronal differentiationNeuronsHuman specificity
2020
Chapter 40 Tourette syndrome
Fasching L, Brady M, Bloch M, Lombroso P, Vaccarino F. Chapter 40 Tourette syndrome. 2020, 675-686. DOI: 10.1016/b978-0-12-813866-3.00040-0.ChaptersTourette syndromeThalamic-cortical circuitryHuman postmortem brain tissueThalamo-cortical circuitryAdult TS patientsStriatal volume lossPostmortem brain tissueEnvironmental risk factorsStriatal interneuronsDopaminergic receptorsRecurrence rateAmeliorate symptomsBasal gangliaRisk factorsFamilial recurrence ratePharmacological strategiesVocal ticsTS patientsAnimal modelsMetabolic hypofunctionComplex neuropsychiatric disorderBrain tissueMolecular abnormalitiesNeuropsychiatric disordersGenetic alterations
2015
How Animal Models Inform Child and Adolescent Psychiatry
Stevens HE, Vaccarino FM. How Animal Models Inform Child and Adolescent Psychiatry. Journal Of The American Academy Of Child & Adolescent Psychiatry 2015, 54: 352-359. PMID: 25901771, PMCID: PMC4407022, DOI: 10.1016/j.jaac.2015.01.019.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRisk factorsPsychiatric disordersAnimal modelsImportance of doseChildhood psychiatric disordersAdolescent psychiatryAnimal model systemsAnimal model workChild psychiatryPsychiatric pathophysiologyBrain developmentChildhood disordersChild psychiatristsBrain functioningBasis of recoveryDisordersBehavioral problemsChildrenClinical workPsychiatryField of childPathophysiologyFactorsDoseNeurochemistryChapter 107 Tourette Syndrome
Lennington J, Bloch M, Scahill L, Szuhay G, Lombroso P, Vaccarino F. Chapter 107 Tourette Syndrome. 2015, 1311-1320. DOI: 10.1016/b978-0-12-410529-4.00107-8.ChaptersTourette syndromeThalamic-cortical circuitryChildhood-onset neuropsychiatric disorderBasal ganglia circuitryStriatal interneuronsAmeliorate symptomsBasal gangliaPharmacological strategiesVocal ticsAnimal modelsPostmortem tissueNeuropsychiatric disordersSyndromeContemporary treatmentHeterogeneous disorderLarge genome-wide association studiesRecent screeningDysfunctionPotential target sitesStereotypic behaviorDisordersGenome-wide association studiesAssociation studiesChemical disruptionDopaminergic
2013
Neurogenesis and Maturation in Neonatal Brain Injury
Salmaso N, Tomasi S, Vaccarino FM. Neurogenesis and Maturation in Neonatal Brain Injury. Clinics In Perinatology 2013, 41: 229-239. PMID: 24524457, PMCID: PMC3925307, DOI: 10.1016/j.clp.2013.10.007.ChaptersConceptsChronic perinatal hypoxiaConsequences of prematurityNeonatal brain injurySevere neurologic deficitsAttention deficit hyperactivityPerinatal hypoxiaNeurologic deficitsPreterm birthPremature birthBrain injuryAnimal modelsCognitive impairmentNeuropsychiatric conditionsMost childrenCognitive delayPartial recoveryIncidenceEnvironmental enrichmentAutism spectrum disorderBirthSpectrum disorderNormal developmentPrematurity
2012
Environmental Enrichment Increases the GFAP+ Stem Cell Pool and Reverses Hypoxia-Induced Cognitive Deficits in Juvenile Mice
Salmaso N, Silbereis J, Komitova M, Mitchell P, Chapman K, Ment LR, Schwartz ML, Vaccarino FM. Environmental Enrichment Increases the GFAP+ Stem Cell Pool and Reverses Hypoxia-Induced Cognitive Deficits in Juvenile Mice. Journal Of Neuroscience 2012, 32: 8930-8939. PMID: 22745493, PMCID: PMC3399175, DOI: 10.1523/jneurosci.1398-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAnimals, NewbornBromodeoxyuridineCell CountCell DifferentiationCognition DisordersDeoxyuridineDisease Models, AnimalEnvironmentEstrogen AntagonistsFemaleGene Expression Regulation, DevelopmentalGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsHumansHypoxiaIdoxuridineKi-67 AntigenMaleMaze LearningMiceMice, Inbred C57BLMice, TransgenicNerve Tissue ProteinsNeurogenesisNeurogliaReceptors, EstrogenStem CellsTamoxifenConceptsHypoxic injuryBrain injuryAstroglial cellsChronic hypoxic injuryDevelopmental brain injuryLow birth weightCell poolEnvironmental enrichmentAdult brain injuryAbnormal lung developmentStem cell poolPerinatal hypoxic injuryFate-mapping modelsSocio-demographic factorsNeurobiological recoveryHippocampal neurogenesisVLBW cohortPremature childrenBirth weightCardiovascular abnormalitiesJuvenile miceAnimal modelsLung developmentInjuryCognitive deficits
2009
Modeling premature brain injury and recovery
Scafidi J, Fagel DM, Ment LR, Vaccarino FM. Modeling premature brain injury and recovery. International Journal Of Developmental Neuroscience 2009, 27: 863-871. PMID: 19482072, PMCID: PMC2783901, DOI: 10.1016/j.ijdevneu.2009.05.009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBrain injuryAnimal modelsSignificant public health problemPremature brain injuryPublic health problemRelevant animal modelsNeurodevelopmental sequelaePreterm brainPreterm infantsPremature birthPreclinical modelsHealth problemsInjuryBrain structuresCellular mechanismsBrainInfantsSchool ageNeuroanatomical structuresVariable degreesRecent insightsEpigenetic mechanismsSequelaeTherapyRecovery
2008
Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for Autism
Vaccarino FM, Grigorenko EL, Smith KM, Stevens HE. Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for Autism. Journal Of Autism And Developmental Disorders 2008, 39: 511-520. PMID: 18850329, PMCID: PMC2847619, DOI: 10.1007/s10803-008-0653-8.Peer-Reviewed Original ResearchConceptsFibroblast growth factorCortical sizeNeuron numberExcitatory/inhibitory balanceGrowth factorCortical excitatory neuronsCortical neuron numberCerebral cortical sizeAutism spectrum disorderNetwork excitabilityInhibitory balanceRisk factorsCortical volumePathogenetic pathwaysExcitatory neuronsSpectrum disorderAnimal modelsBrain volumeDevelopmental alterationsPathologyDisordersSocial deficitsBrain sizeFGF genesSeizures