2006
RNA synthetic biology
Isaacs FJ, Dwyer DJ, Collins JJ. RNA synthetic biology. Nature Biotechnology 2006, 24: 545-554. PMID: 16680139, DOI: 10.1038/nbt1208.Peer-Reviewed Original ResearchConceptsRNA moleculesSynthetic biologyDiverse regulatory rolesRNA synthetic biologyNew biological functionsCellular control systemsSensors of intracellularMammalian systemsRNA componentBiological functionsGene expressionNatural versatilityCellular behaviorRegulatory roleRNA systemsEnvironmental stimuliBiological networksSmall moleculesBiologyNucleic acidsMoleculesYeastProteinBacteriaIntracellular
2004
Engineered riboregulators enable post-transcriptional control of gene expression
Isaacs FJ, Dwyer DJ, Ding C, Pervouchine DD, Cantor CR, Collins JJ. Engineered riboregulators enable post-transcriptional control of gene expression. Nature Biotechnology 2004, 22: 841-847. PMID: 15208640, DOI: 10.1038/nbt986.Peer-Reviewed Original ResearchConceptsStem-loop structureGene expressionPost-transcriptional controlPost-transcriptional regulation systemSmall noncoding RNAsTrans targetsCis-repressive sequenceRibosome bindingNoncoding RNAsEndogenous RNATarget genesCis sequencesRegulatory roleEscherichia coliRNABiological networksRiboregulatorsMechanistic actionGenesExpressionRecent studiesSequenceRegulation systemTranscriptionPromoter