2023
Moderate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity
Vitek W, Sun F, Cardozo E, Hoeger K, Hansen K, Santoro N, Zhang H, Legro R. Moderate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity. F&S Reports 2023, 4: 308-312. PMID: 37719091, PMCID: PMC10504528, DOI: 10.1016/j.xfre.2023.06.004.Peer-Reviewed Original ResearchLive birth rateSteps/dayPhysical activityInfertility trialsLifestyle modificationUnexplained infertilityObese womenBirth rateClomiphene citrate treatmentUS fertility centersClinical pregnancy rateLifestyle modification programTime of enrollmentModerate physical activityPhysical activity goalsMiscarriage rateFertility centerIntrauterine inseminationFitbit activity trackerPregnancy rateSecondary analysisCitrate treatmentActivity goalsModification programWomen
2022
Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria
Baker KC, Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Coward RM, Sun F, Wild R, Masson P, Smith JF, Santoro N, Zhang H, Network R. Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria. F&S Reports 2022, 3: 110-115. PMID: 35789726, PMCID: PMC9250115, DOI: 10.1016/j.xfre.2022.03.003.Peer-Reviewed Original ResearchFertility centerCore laboratoryStrict morphologySecondary cohort analysisPlacebo-controlled trialSame semen sampleMultisite clinical trialLower reference limitSemen samplesInfertility trialsClinical trialsFertility laboratoriesCohort analysisCutoff valueEffect of antioxidantsReference limitsInterobserver agreementCentral laboratoryModerate agreementSemen valuesLack of correlationTrialsGrading criteriaMale fertilityCenter Laboratory
2021
The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial
Knudtson JF, Sun F, Coward RM, Hansen KR, Barnhart KT, Smith J, Legro RS, Diamond MP, Krawetz SA, Zhang H, Usadi R, Baker VL, Santoro N, Steiner AZ. The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Journal Of Assisted Reproduction And Genetics 2021, 38: 3005-3013. PMID: 34455507, PMCID: PMC8609082, DOI: 10.1007/s10815-021-02301-2.Peer-Reviewed Original ResearchConceptsPlasma antioxidant levelsLive birthsClinical trialsSemen parametersAntioxidant levelsVitamin ERank sum testSecondary analysisClinical outcomesNormal rangeBaseline plasma valuesVitamin E levelsWilcoxon rank sum testMale fertilityConclusionsAmong menPrimary endpointDNA fragmentationResultsAt baselineSerum levelsFertility centerE levelsMethodsThis studyMale infertilityFertility outcomesPlasma valuesMale vitamin D status and male factor infertility
Banks N, Sun F, Krawetz SA, Coward RM, Masson P, Smith JF, Trussell JC, Santoro N, Zhang H, Steiner AZ. Male vitamin D status and male factor infertility. Fertility And Sterility 2021, 116: 973-979. PMID: 34289935, PMCID: PMC8561776, DOI: 10.1016/j.fertnstert.2021.06.035.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, SpontaneousAdultBiomarkersClomipheneDietary SupplementsDouble-Blind MethodFemaleFertilityFertility Agents, FemaleHumansInfertility, MaleInsemination, Artificial, HomologousLive BirthMalePregnancyPregnancy RateProspective StudiesRisk FactorsSemenSemen AnalysisTime FactorsTreatment OutcomeUnited StatesVitamin DVitamin D DeficiencyConceptsVitamin D deficiencyLive birth rateMale factor infertilityD deficiencyFactor infertilityD levelsSemen parametersMild male factor infertilityMale partnersVitamin D levelsVitamin D statusRate of miscarriageFemale partnersSperm concentrationBirth rateClinical pregnancyClomiphene citrateD statusDNA fragmentationCumulative pregnancySperm DNA fragmentationVitamin DFertility centerIntrauterine inseminationMonth 4Sperm deoxyribonucleic acid fragmentation: predictors, fertility outcomes, and assays among infertile males
Rios JS, Coward RM, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Sun F, Wild R, Smith JF, Santoro N, Zhang H, Steiner AZ. Sperm deoxyribonucleic acid fragmentation: predictors, fertility outcomes, and assays among infertile males. F&S Reports 2021, 2: 282-288. PMID: 34553152, PMCID: PMC8441563, DOI: 10.1016/j.xfre.2021.06.003.Peer-Reviewed Original ResearchPregnancy outcomesInfertile menSperm deoxyribonucleic acid fragmentationMultivariable linear regression modelsTransferase-mediated dUTP nickDeoxyribonucleic acid fragmentationLower total sperm motilityOvarian stimulationBaseline visitFertility centerTubal patencyIntrauterine inseminationLive birthsFertility outcomesInfertile malesSecondary analysisOlder ageDUTP nickFemale partnersSpearman correlationSperm concentrationSignificant predictorsTotal sperm motilityModest correlationMen