2024
Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease
de Laat B, Hoye J, Stanley G, Hespeler M, Ligi J, Mohan V, Wooten D, Zhang X, Nguyen T, Key J, Colonna G, Huang Y, Nabulsi N, Patel A, Matuskey D, Morris E, Tinaz S. Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease. Npj Parkinson's Disease 2024, 10: 34. PMID: 38336768, PMCID: PMC10858031, DOI: 10.1038/s41531-024-00641-1.Peer-Reviewed Original ResearchDopamine transporterSubstantia nigraDopaminergic neuronsDopamine transporter availabilityNeuroprotective effects of exerciseDopaminergic systemClinical progression of PDEarly PDSubstantiaNeuromelanin contentNigraLoss of dopaminergic neuronsEffects of exerciseNM-MRIDopamineSystem of patientsProgressive loss of dopaminergic neuronsParkinson's diseaseClinical progressionProgression of PDNeuroprotective effectsClinical trialsIntensity exercisePET imagingProgressive loss
2023
Measuring Heart Rate Accurately in Patients With Parkinson Disease During Intense Exercise: Usability Study of Fitbit Charge 4
Colonna G, Hoye J, de Laat B, Stanley G, Ibrahimy A, Tinaz S, Morris E. Measuring Heart Rate Accurately in Patients With Parkinson Disease During Intense Exercise: Usability Study of Fitbit Charge 4. JMIR Biomedical Engineering 2023, 8: e51515. PMID: 38875680, PMCID: PMC11041416, DOI: 10.2196/51515.Peer-Reviewed Original ResearchTheoretical maximum heart rateHeart rateParkinson's diseaseExercise sessionsIntense exerciseExercise programExercise intensityHigh-intensity exercise sessionsEarly-stage Parkinson's diseaseIntensive exercise programAerobic physical exerciseCohort of patientsBackground Parkinson’s diseaseRole of exerciseHigh-intensity exerciseCommon neurodegenerative diseaseMean heart rateMaximum heart rateHR monitorAverage heart rateR interval measurementRecent pilot studyPolar H10Nonmotor symptomsClinical cohort