2024
The trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores
Salto A, Salum G, Hoffmann M, Santoro M, Zugman A, Pan P, Belangero S, Ito L, Doretto V, Croci M, Brañas M, de Giusti C, Da Silva‐Jr F, Ribeiro S, Miguel E, Leckman J. The trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores. JCPP Advances 2024 DOI: 10.1002/jcv2.12268.Peer-Reviewed Original ResearchAnxiety symptomsIntelligence quotientTrajectory class membershipPolygenic risk scoresTrajectory classesLate adolescenceCourse of anxiety symptomsScreen for Child Anxiety Related DisordersTrajectories of anxiety symptomsBrazilian High-Risk CohortYoung adulthoodEffect of intelligence quotientAnxiety related disordersHigh-decreasing classClass membershipLongitudinal studyConfirmatory factor analysisGrowth mixture modelingIncidence of anxiety symptomsInternalizing symptomatologyLow-increasing classHigher IQCognitive abilitiesAnxiety riskFactor analysisChildhood Anxiety Symptoms as a Predictor of Psychotic Experiences in Adolescence in a High-Risk Cohort for Psychiatric Disorders
Machado V, Fonseca L, Barbosa M, Bressan R, Pan P, Rohde L, Miguel E, Salum G, Ziebold C, Gadelha A. Childhood Anxiety Symptoms as a Predictor of Psychotic Experiences in Adolescence in a High-Risk Cohort for Psychiatric Disorders. Schizophrenia Bulletin Open 2024, 5: sgae003. PMID: 39144118, PMCID: PMC11207689, DOI: 10.1093/schizbullopen/sgae003.Peer-Reviewed Original ResearchBrazilian High-Risk CohortCross-lagged panel modelChildhood anxiety symptomsPsychotic experiencesAnxiety symptomsSubclinical psychotic symptomsContinuum of psychosisStandardized self-report questionnairesTime-lagged associationsCross-lagged effectsIncreased levels of anxietySelf-report questionnairesLevels of anxietyPsychosis pronenessPsychotic symptomsPsychiatric disordersSymptom domainsMental illnessAnxietyHigh-risk cohortAnxiety scoresPsychosisAdolescentsPE scoresPanel model
2023
Longitudinal invariance of psychotic experiences in children and adolescents: What do the data tell us?
Barbosa M, Machado V, Ziebold C, Moriyama T, Bressan R, Pan P, Rohde L, Miguel E, Fonseca L, Van Os J, Gadelha A. Longitudinal invariance of psychotic experiences in children and adolescents: What do the data tell us? Schizophrenia Research 2023, 255: 33-40. PMID: 36958268, DOI: 10.1016/j.schres.2023.03.003.Peer-Reviewed Original ResearchConceptsPsychotic experiencesTime pointsHigh-risk cohortPrevious systematic reviewDifferent age groupsDifferent time pointsBaseline evaluationLifetime psychotic experiencesPositive symptomsSystematic reviewAge groupsPerceptual abnormalitiesLongitudinal studyBrazilian High-Risk CohortPsychosis pronenessGood model fit indicesThree-factor solutionChildren
2022
Threat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents
Schäfer J, McLaughlin K, Manfro G, Pan P, Rohde L, Miguel E, Simioni A, Hoffmann M, Salum G. Threat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents. Developmental Science 2022, 26: e13267. PMID: 35417607, PMCID: PMC10028496, DOI: 10.1111/desc.13267.Peer-Reviewed Original ResearchConceptsChild Behavior ChecklistExecutive functionEmotional processingChildhood adversityBrazilian High-Risk CohortForms of adversityPoor developmental outcomesAttention biasAngry facesCognitive tasksCognitive developmentDevelopmental correlatesBehavior ChecklistChild developmentDevelopmental outcomesLongitudinal associationsGeneral psychopathologyPsychopathologyAdversityLatent constructsDifferential associationsWorse performanceDistinct aspectsCognitionMeaningful influence
2021
Predictors of gaming disorder in children and adolescents: a school-based study
Ferreira F, Bambini B, Tonsig G, Fonseca L, Picon F, Pan P, Salum G, Jackowski A, Miguel E, Rohde L, Bressan R, Gadelha A. Predictors of gaming disorder in children and adolescents: a school-based study. Brazilian Journal Of Psychiatry 2021, 43: 289-292. PMID: 32756806, PMCID: PMC8136393, DOI: 10.1590/1516-4446-2020-0964.Peer-Reviewed Original ResearchConceptsMental disordersWell-Being Behavior AssessmentHigh-risk cohortLogistic regression modelsSchool-based studyGaming disorderPsychiatric disordersUnhealthy patternsDisorder ratesSchool-based sampleDisordersSignificant predictorsFurther riskBrazilian High-Risk CohortCommunity sampleHigh rateBehavior changeMore hoursRegression modelsChildrenPredictorsAdolescentsHoursBehavior assessmentPattern variables
2018
Effect of male-specific childhood trauma on telomere length
Xavier G, Spindola L, Ota V, Carvalho C, Maurya P, Tempaku P, Moretti P, Mazotti D, Sato J, Brietzke E, Miguel E, Grassi-Oliveira R, Mari J, Bressan R, Gadelha A, Pan P, Belangero S. Effect of male-specific childhood trauma on telomere length. Journal Of Psychiatric Research 2018, 107: 104-109. PMID: 30384090, DOI: 10.1016/j.jpsychires.2018.10.012.Peer-Reviewed Original ResearchConceptsHigh-risk cohortTelomere lengthImportant risk factorCross-sectional studyChild maltreatmentEarly life stressChild Behavior Checklist scoresSchool-based studySerious lifelong consequencesQuantitative polymerase chain reactionHistory of CMPolymerase chain reactionRisk factorsPsychiatric symptomsPsychiatric disordersMultiplex quantitative polymerase chain reactionLifelong consequencesBlood cellsChildhood traumaCM scoreLife stressChain reactionSexBrazilian High-Risk CohortShort telomeres