2024
Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial
Herlihy N, Cakiroglu Y, Whitehead C, Reig A, Tiras B, Scott R, Seli E. Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial. Human Reproduction 2024, 39: 1495-1503. PMID: 38725194, DOI: 10.1093/humrep/deae093.Peer-Reviewed Original ResearchPoor ovarian responseControlled ovarian stimulationHistory of poor ovarian responsePremature ovarian insufficiencyPlatelet-rich plasmaPlatelet-rich plasma injectionsMature oocyte yieldRandomized controlled trialsPRP injectionEuploid blastocystsOvarian responseOocyte yieldOocyte retrievalIVF outcomesIntraovarian platelet-rich plasmaUniversity-affiliated reproductive centerIVF historyMature oocytesSustained implantationDATE OF FIRST PATIENT’S ENROLMENT:Euploid embryo transferInclusion criteriaPlatelet-rich plasma preparationsPreimplantation genetic testingOvarian reserve tests
2020
The appraisal of body content (ABC) trial: obesity does not significantly impact gamete production in infertile men and women
Kim J, Juneau C, Patounakis G, Morin S, Neal S, Seli E, Scott R. The appraisal of body content (ABC) trial: obesity does not significantly impact gamete production in infertile men and women. Journal Of Assisted Reproduction And Genetics 2020, 37: 2733-2742. PMID: 32827101, PMCID: PMC7642175, DOI: 10.1007/s10815-020-01930-3.Peer-Reviewed Original ResearchConceptsBody mass indexLower serum AMHLower serum FSHOvarian reserve parametersPresence of PCOSControlled ovarian hyperstimulationNormal-weight counterpartsMature oocytesPercent body fatBF categoriesOvarian hyperstimulationSerum AMHOvarian reservePCOS diagnosisSerum FSHIVF outcomesLess muscle massOvarian responseMass indexFemale obesityInfertility treatmentReserve parametersBody fatInfertile menObesity
2019
Cumulus cells have longer telomeres than leukocytes in reproductive-age women
Lara-Molina EE, Franasiak JM, Marin D, Tao X, Díaz-Gimeno P, Florensa M, Martin M, Seli E, Pellicer A. Cumulus cells have longer telomeres than leukocytes in reproductive-age women. Fertility And Sterility 2019, 113: 217-223. PMID: 31594634, DOI: 10.1016/j.fertnstert.2019.08.089.Peer-Reviewed Original ResearchConceptsLeukocyte telomere lengthGranulosa cellsCumulus cellsTelomere lengthAssisted reproductive technology centerRelative leukocyte telomere lengthProspective noninterventional studyAntimüllerian hormone levelsAntral follicle countReproductive-age womenReproductive technology centerLonger telomeresNoninterventional studyFollicle countMean ageHormone levelsFollicular environmentMAIN OUTCOMEMature folliclesStudy subjectsSignificant associationFollicular cellsMean numberMature oocytesSignificant differences
2016
Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity
Babayev E, Wang T, Szigeti-Buck K, Lowther K, Taylor HS, Horvath T, Seli E. Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity. Maturitas 2016, 93: 121-130. PMID: 27523387, PMCID: PMC5064871, DOI: 10.1016/j.maturitas.2016.06.015.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesUnfolded protein response genesProtein response genesMitochondrial DNAMitochondrial dynamicsMitochondrial stressResponse genesMammalian reproductionMitochondria morphologyStressful conditionsMitochondrial changesMitochondriaROS levelsMtDNA levelsElevated expressionMtDNA quantityOxygen speciesOocytesGenesMature oocytesNumerous aspectsExpressionReproductive agingMII oocytesFollicle-enclosed oocytes