2021
DIAPH1 Variants in Non–East Asian Patients With Sporadic Moyamoya Disease
Kundishora AJ, Peters ST, Pinard A, Duran D, Panchagnula S, Barak T, Miyagishima DF, Dong W, Smith H, Ocken J, Dunbar A, Nelson-Williams C, Haider S, Walker RL, Li B, Zhao H, Thumkeo D, Marlier A, Duy PQ, Diab NS, Reeves BC, Robert SM, Sujijantarat N, Stratman AN, Chen YH, Zhao S, Roszko I, Lu Q, Zhang B, Mane S, Castaldi C, López-Giráldez F, Knight JR, Bamshad MJ, Nickerson DA, Geschwind DH, Chen SL, Storm PB, Diluna ML, Matouk CC, Orbach DB, Alper SL, Smith ER, Lifton RP, Gunel M, Milewicz DM, Jin SC, Kahle KT. DIAPH1 Variants in Non–East Asian Patients With Sporadic Moyamoya Disease. JAMA Neurology 2021, 78: 993-1003. PMID: 34125151, PMCID: PMC8204259, DOI: 10.1001/jamaneurol.2021.1681.Peer-Reviewed Original ResearchConceptsSporadic moyamoya diseaseMoyamoya diseaseValidation cohortDiscovery cohortIntracranial internal carotid arteryRisk genesBilateral moyamoya diseaseTransfusion-dependent thrombocytopeniaLarger validation cohortNon-East Asian patientsInternal carotid arteryAsian individualsCompound heterozygous variantsNon-East AsiansProgressive vasculopathyTransmitted variantsAsian patientsChildhood strokeMedical recordsCarotid arteryTherapeutic ramificationsMAIN OUTCOMEMouse brain tissuePatientsUS hospitals
2020
Self-reported health without clinically measurable benefits among adult users of multivitamin and multimineral supplements: a cross-sectional study
Paranjpe MD, Chin AC, Paranjpe I, Reid NJ, Duy PQ, Wang JK, O'Hagan R, Arzani A, Haghdel A, Lim CC, Orhurhu V, Urits I, Ngo AL, Glicksberg BS, Hall KT, Mehta D, Cooper RS, Nadkarni GN. Self-reported health without clinically measurable benefits among adult users of multivitamin and multimineral supplements: a cross-sectional study. BMJ Open 2020, 10: e039119. PMID: 33148746, PMCID: PMC7643504, DOI: 10.1136/bmjopen-2020-039119.Peer-Reviewed Original ResearchConceptsMeasurable health outcomesBetter overall healthHealth outcomesOverall healthChronic diseasesSelf-reported overall healthSelf-rated health statusNational Health Interview SurveyHealth conditionsPsychological distressFunctional health outcomesMultiple clinical trialsCross-sectional studyGeneral adult populationHealth Interview SurveyNon-specific psychological distressBetter health outcomesMeasurable health benefitsSelf-reported healthCross-sectional analysisComplementary health practicesPsychological Distress ScaleNon-institutionalised populationDaily multivitaminMultivitamin useSpinal cord stimulation and psychotropic medication use: Missing piece to the puzzle?
Hwang BY, Negoita S, Duy PQ, Anderson WS. Spinal cord stimulation and psychotropic medication use: Missing piece to the puzzle? Journal Of Clinical Neuroscience 2020, 81: 158-160. PMID: 33222907, PMCID: PMC9586422, DOI: 10.1016/j.jocn.2020.09.038.Peer-Reviewed Original ResearchConceptsPsychotropic medicationsSpinal cord stimulator therapyLow explantation rateTimes less likelihoodClasses of medicationsChronic pain managementChronic pain patientsPsychotropic medication useSpinal cord stimulationMajority of casesMedication usePain managementPain patientsDaily dosageTreatment failureCord stimulationDevice explantationRetrospective studySCS patientsExplantation ratePsychotropic useTreatment successMedication statusMedicationsModulatory effectsWorse overall health status negatively impacts satisfaction with breast reconstruction
Mehta SK, Olawoyin O, Chouairi F, Duy PQ, Mets EJ, Gabrick KS, Le NK, Avraham T, Alperovich M. Worse overall health status negatively impacts satisfaction with breast reconstruction. Journal Of Plastic Reconstructive & Aesthetic Surgery 2020, 73: 2056-2062. PMID: 32972879, DOI: 10.1016/j.bjps.2020.08.093.Peer-Reviewed Original ResearchConceptsBREAST-Q scoresPatient-reported outcomesOverall health statusBreast reconstructionOverall healthASA classificationHealth statusGeneral linear modelAnesthesiologists physical status classificationYale-New Haven HospitalWorse overall health statusBREAST-Q outcomesHealth-related qualityPhysical status classificationNew Haven HospitalEffect of ASAASA 1Independent predictorsPatient factorsPostoperative satisfactionBreast surgeryPatient satisfactionASA 2PatientsRelevant covariatesAntiepileptic drug withdrawal and seizure severity in the epilepsy monitoring unit
Duy PQ, Krauss GL, Crone NE, Ma M, Johnson EL. Antiepileptic drug withdrawal and seizure severity in the epilepsy monitoring unit. Epilepsy & Behavior 2020, 109: 107128. PMID: 32417383, DOI: 10.1016/j.yebeh.2020.107128.Peer-Reviewed Original ResearchConceptsEpilepsy monitoring unitBilateral tonic-clonic seizuresSevere seizure typeTonic-clonic seizuresFocal seizuresSeizure typesAED doseLorazepam administrationAntiepileptic drug reductionAntiepileptic drug withdrawalDrug withdrawal ratesReceiver-operating characteristic curveRisk of complicationsAED dosageAED withdrawalEMU stayConsecutive patientsSeizure clustersAED reductionDrug withdrawalSeizure severityPresurgical patientsDrug reductionSeizuresEffective dose