2020
The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk
Spiegelman D, Lovato LC, Khudyakov P, Wilkens TL, Adebamowo CA, Adebamowo SN, Appel LJ, Beulens JW, Coughlin JW, Dragsted LO, Edenberg HJ, Eriksen JN, Estruch R, Grobbee DE, Gulayin PE, Irazola V, Krystal JH, Lazo M, Murray MM, Rimm EB, Schrieks IC, Williamson JD, Mukamal KJ. The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk. European Journal Of Preventive Cardiology 2020, 27: 1967-1982. PMID: 32250171, PMCID: PMC7541556, DOI: 10.1177/2047487320912376.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionCardiovascular Health TrialAlcohol consumptionHealth trialsCardiovascular diseaseModerate alcoholNon-fatal ischemic strokeNon-fatal myocardial infarctionPrimary composite endpointCongestive heart failureCoronary heart diseaseModerate alcohol consumersAdults 50 yearsPublic health guidelinesAlcohol use disorderPreferred alcoholic beverageCardiometabolic effectsCardiometabolic riskCarotid revascularizationIschemic strokeSecondary outcomesComposite endpointHeart failurePrimary outcomeMyocardial infarction
2012
Cohort studies around the world: Methodologies, research questions and integration to address the emerging global epidemic of chronic diseases
Nair H, Shu XO, Volmink J, Romieu I, Spiegelman D. Cohort studies around the world: Methodologies, research questions and integration to address the emerging global epidemic of chronic diseases. Public Health 2012, 126: 202-205. PMID: 22325615, DOI: 10.1016/j.puhe.2011.12.013.Peer-Reviewed Original ResearchMeSH KeywordsChronic DiseaseCohort StudiesEpidemicsGlobal HealthHumansInternationalityResearch DesignConceptsChronic diseasesCohort studyChronic non-communicable diseasesNon-communicable chronic diseasesDual disease burdenCommunicable infectious diseasesNon-communicable diseasesMultiple cohort studiesResource-constrained settingsDisease burdenRisk factorsLifestyle changesGlobal epidemicInfectious diseasesDiseaseDisease distributionEpidemicBurdenPopulationSettingDramatic increase