2024
The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition
Magrou L, Joyce M, Froudist-Walsh S, Datta D, Wang X, Martinez-Trujillo J, Arnsten A. The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition. Cerebral Cortex 2024, 34: bhae174. PMID: 38771244, PMCID: PMC11107384, DOI: 10.1093/cercor/bhae174.Peer-Reviewed Original ResearchConceptsInter-areal connectionsVisual cortexPrimary visual cortexHigher cortical areasMacaque cortexPrimate specializationHigher cognitionPrimate cortexV1Working memory storageDendritic spine densityTop-down regulationPrefrontal cortexConnection structureSpine densityFunctional segregationCortical areasFrontal areasCortexConnectomeNetwork organizationMemory storageMultimodal association
2023
Interrogating the Etiology of Sporadic Alzheimer’s Disease Using Aging Rhesus Macaques: Cellular, Molecular, and Cortical Circuitry Perspectives
Datta D. Interrogating the Etiology of Sporadic Alzheimer’s Disease Using Aging Rhesus Macaques: Cellular, Molecular, and Cortical Circuitry Perspectives. The Journals Of Gerontology Series A 2023, 78: 1523-1534. PMID: 37279946, PMCID: PMC10460555, DOI: 10.1093/gerona/glad134.Peer-Reviewed Original ResearchConceptsPrimate dorsolateral prefrontal cortexSporadic Alzheimer's diseaseAlzheimer's diseaseDorsolateral prefrontal cortexRhesus macaquesPrefrontal cortexSignificant risk factorsHuman Alzheimer's diseaseAspartic acid (NMDA) receptorsNonhuman primate modelNovel therapeutic strategiesCalcium-buffering proteinsPattern of pathologyInflammatory cascadeTau pathologyNeuropathological cascadeSynaptic dysfunctionRisk factorsPrimate modelNeurofibrillary tanglesAmyloid plaquesDendritic spinesTherapeutic strategiesGenetic predispositionAnimal models
2021
Studies of aging nonhuman primates illuminate the etiology of early‐stage Alzheimer's‐like neuropathology: An evolutionary perspective
Arnsten AFT, Datta D, Preuss TM. Studies of aging nonhuman primates illuminate the etiology of early‐stage Alzheimer's‐like neuropathology: An evolutionary perspective. American Journal Of Primatology 2021, 83: e23254. PMID: 33960505, PMCID: PMC8550995, DOI: 10.1002/ajp.23254.Peer-Reviewed Original ResearchConceptsTau pathologyAssociation cortexAlzheimer's diseaseTau phosphorylationNMDAR-NR2BRhesus monkeysCognitive deficitsMonkey dorsolateral prefrontal cortexAlzheimer-like neuropathologyInternal calcium releaseGenetic mouse modelsDorsolateral prefrontal cortexSynaptic lossNeurofibrillary tanglesAmyloid plaquesMouse modelEarly molecular eventsSporadic formsAutosomal dominant formCalcium releasePerfusion fixationCortexPrefrontal cortexNonhuman primatesPathology
2020
The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex
Arnsten AFT, Datta D, Wang M. The genie in the bottle-magnified calcium signaling in dorsolateral prefrontal cortex. Molecular Psychiatry 2020, 26: 3684-3700. PMID: 33319854, PMCID: PMC8203737, DOI: 10.1038/s41380-020-00973-3.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexCognitive disordersPrefrontal cortexPrimate dorsolateral prefrontal cortexHigher cortical circuitsPrimary visual cortexInternal calcium releaseRisk of schizophreniaAge-related lossLevels of calciumDendritic atrophyAmyloid pathologyCalcium binding proteinInflammatory insultCalcium overloadTau phosphorylationCortical circuitsDendritic spinesNeuronal firingCalcium channelsAssociation cortexSynaptic efficacyVisual cortexAlzheimer's diseaseSpecial molecular mechanismHypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease
Arnsten AFT, Datta D, Del Tredici K, Braak H. Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease. Alzheimer's & Dementia 2020, 17: 115-124. PMID: 33075193, PMCID: PMC7983919, DOI: 10.1002/alz.12192.Peer-Reviewed Original ResearchConceptsAbnormal tau phosphorylationTau pathologyProjection neuronsTau phosphorylationAssociation cortexAlzheimer's diseaseBrain tau pathologySporadic Alzheimer's diseaseSusceptible microenvironmentCalcium dysregulationVulnerable neuronsAβ plaquesAβ productionSporadic formsSAD pathologyRhesus monkeysAbnormal phosphorylationPathological eventsDiseaseAβ oligomersPathologyNeuronsVicious cycleCortexTau
2016
Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?
Yan Z, Kim E, Datta D, Lewis D, Soderling S. Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders? Journal Of Neuroscience 2016, 36: 11411-11417. PMID: 27911743, PMCID: PMC5125208, DOI: 10.1523/jneurosci.2360-16.2016.Peer-Reviewed Original ResearchConceptsMental disordersActivity-dependent modulationCritical neural pathwaysGenetic risk allelesExcitatory synapsesNeurodevelopmental disturbancesNeural pathwaysBrain disordersSynaptic cytoskeletonRisk allelesDisordersNeurodevelopmental disordersActin dysregulationSpine structureConvergent mechanismsAutism spectrum disorderPostsynaptic complexSpectrum disorderPathwayActin cytoskeletonCandidate genesGenetic evidenceActin polymerizationAbnormalitiesSchizophreniaAltered Expression of ARP2/3 Complex Signaling Pathway Genes in Prefrontal Layer 3 Pyramidal Cells in Schizophrenia
Datta D, Arion D, Roman K, Volk D, Lewis D. Altered Expression of ARP2/3 Complex Signaling Pathway Genes in Prefrontal Layer 3 Pyramidal Cells in Schizophrenia. American Journal Of Psychiatry 2016, 174: 163-171. PMID: 27523502, PMCID: PMC5288270, DOI: 10.1176/appi.ajp.2016.16020204.Peer-Reviewed Original ResearchConceptsLayer 3 pyramidal cellsDorsolateral prefrontal cortexPyramidal cellsParvalbumin interneuronsGray matterExcessive dopamine releaseDendritic spine densityCortical pyramidal cellsCommon final pathwayStriatal hyperdopaminergiaDLPFC gray matterVentral mesencephalonSpine deficitsSpine lossSpine densityExcitatory projectionsCognitive dysfunctionPairs of schizophreniaDopamine cellsDopamine releaseDendritic spinesComparison subjectsFinal pathwaySubcortical hyperdopaminergiaPrefrontal cortexLayer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in Schizophrenia
Hoftman G, Datta D, Lewis D. Layer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in Schizophrenia. Biological Psychiatry 2016, 81: 862-873. PMID: 27455897, PMCID: PMC5136518, DOI: 10.1016/j.biopsych.2016.05.022.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexInhibitory gamma-aminobutyric acid (GABA) neuronsGamma-aminobutyric acid (GABA) neuronsPrefrontal cortexCertain clinical featuresExcitatory pyramidal neuronsAdverse environmental exposuresDisorders of neurodevelopmentNature of schizophreniaDLPFC circuitryInhibitory circuitryClinical featuresPyramidal neuronsDisease processDevelopmental refinementMemory impairmentMemory alterationsDevelopmental disturbancesNeural circuitrySchizophreniaEnvironmental exposuresLate developmental processesNeurodevelopmental disordersSpecific populationsAlterations
2015
Altered Expression of CDC42 Signaling Pathway Components in Cortical Layer 3 Pyramidal Cells in Schizophrenia
Datta D, Arion D, Corradi J, Lewis D. Altered Expression of CDC42 Signaling Pathway Components in Cortical Layer 3 Pyramidal Cells in Schizophrenia. Biological Psychiatry 2015, 78: 775-785. PMID: 25981171, PMCID: PMC4600637, DOI: 10.1016/j.biopsych.2015.03.030.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntipsychotic AgentsBenzodiazepinesCdc42 GTP-Binding ProteinCytoskeletal ProteinsFemaleGene Expression RegulationGTP-Binding Protein RegulatorsHaloperidolHumansLaser Capture MicrodissectionLim KinasesMacaca fascicularisMaleMiddle AgedOlanzapineP21-Activated KinasesPrefrontal CortexRho GTP-Binding ProteinsRho Guanine Nucleotide Dissociation Inhibitor alphaRNA-Binding ProteinsSchizophreniaSignal TransductionConceptsSerine/threonine protein kinaseThreonine protein kinaseActin cytoskeletonProtein kinaseCdc42 effector proteinsCell type-specific fashionMessenger RNA levelsCell division cycle 42Altered expressionType-specific fashionDLPFC gray matterRNA levelsEffector proteinsActin dynamicsPathway componentsSame transcriptKey organizerMessenger RNALaser microdissectionSynergistic alterationsCdc42CytoskeletonQuantitative polymerase chain reactionSpine formationKinaseDistinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder
Arion D, Corradi J, Tang S, Datta D, Boothe F, He A, Cacace A, Zaczek R, Albright C, Tseng G, Lewis D. Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder. Molecular Psychiatry 2015, 20: 1397-1405. PMID: 25560755, PMCID: PMC4492919, DOI: 10.1038/mp.2014.171.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAnimalsAntipsychotic AgentsFemaleGene Expression ProfilingGene Expression RegulationHumansLaser Capture MicrodissectionMacaca fascicularisMaleMiddle AgedMitochondrial ProteinsOligonucleotide Array Sequence AnalysisPrefrontal CortexPsychotic DisordersPyramidal CellsRNA, MessengerSchizophreniaSignal TransductionTranscriptomeUbiquitin
2014
Functional Maturation of GABA Synapses During Postnatal Development of the Monkey Dorsolateral Prefrontal Cortex
Gonzalez-Burgos G, Miyamae T, Pafundo D, Yoshino H, Rotaru D, Hoftman G, Datta D, Zhang Y, Hammond M, Sampson A, Fish K, Ermentrout G, Lewis D. Functional Maturation of GABA Synapses During Postnatal Development of the Monkey Dorsolateral Prefrontal Cortex. Cerebral Cortex 2014, 25: 4076-4093. PMID: 24904071, PMCID: PMC4626828, DOI: 10.1093/cercor/bhu122.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAge FactorsAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsAnimals, NewbornCalcium Channel BlockersExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFemaleGABA AntagonistsGamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsLysineMacaca mulattaModels, NeurologicalNeuronsOmega-Agatoxin IVAPrefrontal CortexPyridazinesSynapsesConceptsDorsolateral prefrontal cortexSynapse densityPyramidal cellsPrepubertal ageParvalbumin-positive GABA neuronsMonkey dorsolateral prefrontal cortexPrefrontal cortexPrimate dorsolateral prefrontal cortexInhibitory synapse densityInhibitory postsynaptic currentsAdult macaque monkeysCortical network activityDevelopment of GABAYoung adult ageDlPFC circuitsGamma frequency oscillationsGABA neuronsGABA synapsesInhibitory synaptogenesisPostsynaptic currentsPeripubertal periodSynaptic appositionsGamma band powerMacaque monkeysFunctional maturationDevelopmental Expression Patterns of GABAA Receptor Subunits in Layer 3 and 5 Pyramidal Cells of Monkey Prefrontal Cortex
Datta D, Arion D, Lewis D. Developmental Expression Patterns of GABAA Receptor Subunits in Layer 3 and 5 Pyramidal Cells of Monkey Prefrontal Cortex. Cerebral Cortex 2014, 25: 2295-2305. PMID: 24610118, PMCID: PMC4494034, DOI: 10.1093/cercor/bhu040.Peer-Reviewed Original ResearchConceptsGABAA receptor subunitsPyramidal cellsMonkey prefrontal cortexReceptor subunitsSubunit expressionLayer 3 pyramidal cellsGABAA receptor subunit expressionPrefrontal cortexGABAA receptor subunit mRNAsLayer 5 pyramidal cellsReceptor subunit changesPrefrontal pyramidal neuronsReceptor subunit expressionPyramidal neuron activityGlutamate receptor subunitsReceptor subunit mRNAsPyramidal cell firingPostnatal developmental changesPyramidal neuronsGABAA receptorsInhibitory inputsNeuron activityFunctional maturationPostnatal developmentCell firing