Featured Publications
Cumulative live birth rates with autologous oocytes plateau with fewer number of cycles for each year of age > 42
Seifer D, Wang S, Frankfurter D. Cumulative live birth rates with autologous oocytes plateau with fewer number of cycles for each year of age > 42. Reproductive Biology And Endocrinology 2023, 21: 94. PMID: 37872609, PMCID: PMC10591412, DOI: 10.1186/s12958-023-01144-z.Peer-Reviewed Original ResearchConceptsCumulative live birth rateLive birth rateART cyclesBirth rateDesignRetrospective cohort studyPrior ART cyclesUse of ICSIEtiology of infertilityNumber of oocytesAge categoriesSART CORS databaseYears of ageTreatment cycle numberRace/ethnicityAutologous cyclesResultsBetween 2014Ovarian reserveCohort studyBlastocyst transferWomen 46Women 42Age 45Live birthsMAIN OUTCOMEPhysician expectations
2024
Age-related increase in live-birth rates of first frozen thaw embryo versus first fresh transfer in initial assisted reproductive technology cycles without PGT
Wang S, Seifer D. Age-related increase in live-birth rates of first frozen thaw embryo versus first fresh transfer in initial assisted reproductive technology cycles without PGT. Reproductive Biology And Endocrinology 2024, 22: 42. PMID: 38615016, PMCID: PMC11015537, DOI: 10.1186/s12958-024-01210-0.Peer-Reviewed Original ResearchConceptsFrozen-thawed embryo transferCumulative live birth rateLive birth rateDiminished ovarian reservePreimplantation genetic testingMultivariate logistic regressionFresh transferLive birth outcomesLive birthsEmbryo transferAssisted reproductive technologyART cyclesEndometrial receptivityBirth outcomesFrozen-thawed embryo transfer cyclesOdds of live birthAssisted reproductive technology cyclesChance of live birthFresh embryo transferFrozen-thawed cyclesFrozen-thawed embryosMale factor infertilityRetrospective cohort studyEmbryo transfer methodsAge groups
2020
High serum Antimullerian hormone levels are associated with lower live birth rates in women with polycystic ovarian syndrome undergoing assisted reproductive technology
Tal R, Seifer CM, Khanimov M, Seifer DB, Tal O. High serum Antimullerian hormone levels are associated with lower live birth rates in women with polycystic ovarian syndrome undergoing assisted reproductive technology. Reproductive Biology And Endocrinology 2020, 18: 20. PMID: 32156287, PMCID: PMC7065318, DOI: 10.1186/s12958-020-00581-4.Peer-Reviewed Original ResearchConceptsLive birth rateLower live birth ratesHigh AMH groupAMH groupPCOS womenHigh AMHAMH concentrationsFirst fresh IVF/ICSI cycleBirth rateFresh IVF/ICSI cyclesGreater clinical pregnancy ratesSerum antimullerian hormone (AMH) levelsIVF/ICSI cyclesAntimullerian hormone levelsClinical pregnancy rateControlled ovarian stimulationRetrospective cohort studySerum AMH levelsPolycystic ovarian syndromeSerum AMH concentrationsLive birth outcomesNumber of embryosAMH levelsGonadotropin doseOvarian stimulation
2019
A counterintuitive lesson in family planning? Patience first: taking a “gap year” after live birth from assisted reproductive technology before frozen embryo transfer is performed
Seifer DB, Kallen AN. A counterintuitive lesson in family planning? Patience first: taking a “gap year” after live birth from assisted reproductive technology before frozen embryo transfer is performed. Fertility And Sterility 2019, 111: 1109-1110. PMID: 31056317, DOI: 10.1016/j.fertnstert.2019.03.017.Peer-Reviewed Original Research
2018
Antimüllerian hormone as a predictor of live birth following assisted reproduction: an analysis of 85,062 fresh and thawed cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012–2013
Tal R, Seifer DB, Wantman E, Baker V, Tal O. Antimüllerian hormone as a predictor of live birth following assisted reproduction: an analysis of 85,062 fresh and thawed cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012–2013. Fertility And Sterility 2018, 109: 258-265. PMID: 29331235, DOI: 10.1016/j.fertnstert.2017.10.021.Peer-Reviewed Original ResearchAdultAnti-Mullerian HormoneArea Under CurveBiomarkersChi-Square DistributionCryopreservationDatabases, FactualEmbryo TransferFemaleFertilization in VitroHumansInfertilityLive BirthLogistic ModelsMaleOdds RatioPregnancyPregnancy RateRetrospective StudiesRisk FactorsROC CurveSingle Embryo TransferTime FactorsTreatment Outcome
2015
Prognostic indicators of assisted reproduction technology outcomes of cycles with ultralow serum antimüllerian hormone: a multivariate analysis of over 5,000 autologous cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012–2013
Seifer DB, Tal O, Wantman E, Edul P, Baker VL. Prognostic indicators of assisted reproduction technology outcomes of cycles with ultralow serum antimüllerian hormone: a multivariate analysis of over 5,000 autologous cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012–2013. Fertility And Sterility 2015, 105: 385-393.e3. PMID: 26515380, DOI: 10.1016/j.fertnstert.2015.10.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Mullerian HormoneBiomarkersCryopreservationDatabases, FactualEmbryo TransferFemaleFertilityFertilization in VitroHumansInfertilityLinear ModelsLive BirthLogistic ModelsMiddle AgedMultivariate AnalysisOocyte RetrievalPatient SelectionPregnancyPregnancy RatePregnancy, MultipleReproductive Techniques, AssistedRetrospective StudiesRisk AssessmentRisk FactorsTreatment OutcomeYoung AdultConceptsLive birth rateAntimüllerian hormoneCancellation rateAMH levelsAssisted Reproductive Technology Clinic Outcome Reporting System databaseAssisted reproduction technology (ART) outcomesEmbryo cryopreservation ratesSerum antimüllerian hormoneTotal cancellation rateMultiple birth ratesReporting System databaseCycle startAutologous cyclesClinical pregnancyCycle cancellationPrognostic factorsAMH valuesFresh cyclesCycle outcomePrognostic indicatorAMH concentrationsRetrospective analysisMAIN OUTCOMEEmbryo transferMultivariate analysis
2014
Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011
Butts SF, Owen C, Mainigi M, Senapati S, Seifer DB, Dokras A. Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011. Fertility And Sterility 2014, 102: 1041-1047.e1. PMID: 25086790, PMCID: PMC4184996, DOI: 10.1016/j.fertnstert.2014.06.043.Peer-Reviewed Original ResearchMeSH KeywordsChi-Square DistributionEmbryo Culture TechniquesEmbryo TransferFemaleHumansInfertility, FemaleLive BirthLogistic ModelsOdds RatioOvarian ReservePregnancyPregnancy RatePrimary Ovarian InsufficiencyRegistriesRetrospective StudiesRisk FactorsSperm Injections, IntracytoplasmicTime FactorsTreatment OutcomeUnited StatesConceptsDiminished ovarian reserveIntracytoplasmic sperm injectionElevated FSHLive birthsOvarian reserveART cyclesSperm injectionAssisted Reproductive Technology Clinic Outcome Reporting System databaseClinical pregnancy rateRetrospective cohort studyLive birth rateReproductive technology outcomesAssisted reproduction cyclesCombination of ICSIReporting System databaseCohort studyPrimary diagnosisImproved outcomesPregnancy rateMAIN OUTCOMELower oddsDiminished oddsFSHOnly indicationTechnology outcomes
2012
Anti-Müllerian hormone as an independent predictor of twin versus singleton pregnancy in fresh cycles
Tal R, Seifer DB, Khanimov M, Schwartz E, Grazi RV, Malter HE. Anti-Müllerian hormone as an independent predictor of twin versus singleton pregnancy in fresh cycles. Reproductive BioMedicine Online 2012, 26: 360-367. PMID: 23419793, DOI: 10.1016/j.rbmo.2012.12.002.Peer-Reviewed Original ResearchConceptsAnti-Müllerian hormoneSerum AMH concentrationsFresh non-donor cyclesSerum anti-Müllerian hormoneNon-donor cyclesTwin pregnanciesAMH concentrationsSingleton pregnanciesIndependent predictorsIncidence of twinsFresh cyclesMultiple pregnanciesFertility clinicsPossible predictorsEgg reserveQuantitative ovarian responseLive birth rateChance of pregnancyROC curve analysisSignificant predictive abilityMultiple gestationsOvarian responseTwin gestationsRetrospective studyPregnancy rate
2011
Random anti-Müllerian hormone (AMH) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels
Buyuk E, Seifer DB, Younger J, Grazi RV, Lieman H. Random anti-Müllerian hormone (AMH) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels. Fertility And Sterility 2011, 95: 2369-2372. PMID: 21497340, DOI: 10.1016/j.fertnstert.2011.03.071.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Mullerian HormoneBiomarkersChi-Square DistributionEmbryo TransferFemaleFertilization in VitroFollicle Stimulating Hormone, HumanFollicular PhaseHumansInfertility, FemaleNew YorkOocyte RetrievalOvulationOvulation InductionPregnancyPregnancy RateRetrospective StudiesTime FactorsTreatment OutcomeUp-RegulationConceptsAnti-Müllerian hormoneNumber of oocytesClinical pregnancy rateSerum AMH levelsDiminished ovarian reserveAMH levelsFSH levelsDay 3 embryosElevated FSHOvarian responseART cyclesPregnancy rateEarly follicular FSH levelsFollicle-stimulating hormone levelsSerum anti-Müllerian hormoneCycle cancellation rateSerum FSH levelsReproductive technology programCycle cancellationOvarian reserveRetrospective studyHormone levelsMAIN OUTCOMECancellation rateRandom sera
2004
Impact of retained embryos on the outcome of assisted reproductive technologies
Lee HC, Seifer DB, Shelden RM. Impact of retained embryos on the outcome of assisted reproductive technologies. Fertility And Sterility 2004, 82: 334-337. PMID: 15302280, DOI: 10.1016/j.fertnstert.2004.01.035.Peer-Reviewed Original ResearchConceptsEmbryo transfer cyclesPregnancy outcomesEmbryo transferTransfer cyclesTransfer catheterInitial embryo transferEmbryo transfer catheterAssisted reproductive technology practiceRetained embryosOocyte retrievalImplantation rateDelivery ratePregnancy rateRetrospective analysisMAIN OUTCOMEReproductive technology practiceEmbryo cyclesUse of ultrasoundCatheterAdverse effectsFertilization programFrozen embryosReproductive technologiesOutcomesEmbryo retention
2001
Single blastocyst transfer in women at risk of ovarian hyperstimulation syndrome
Trout S, Bohrer M, Seifer D. Single blastocyst transfer in women at risk of ovarian hyperstimulation syndrome. Fertility And Sterility 2001, 76: 1066-1067. PMID: 11704139, DOI: 10.1016/s0015-0282(01)02838-2.Peer-Reviewed Original ResearchContribution of diminished ovarian reserve to hypofertility associated with endometriosis.
Hock DL, Sharafi K, Dagostino L, Kemmann E, Seifer DB. Contribution of diminished ovarian reserve to hypofertility associated with endometriosis. The Journal Of Reproductive Medicine 2001, 46: 7-10. PMID: 11209637.Peer-Reviewed Original ResearchConceptsStage III/IV endometriosisStage I/II endometriosisOvarian reserveFSH levelsFertilization/embryo transferHigh E2 levelsStage of endometriosisDay 3 levelsMale factor infertilityCase-control studyAge-matched controlsFactor infertilityE2 levelsEndometriosisEmbryo transferTotal groupProgressive lossControl levelsWomenSignificant differencesE2FSHLevelsPatientsInfertility
1998
Predicting probabilities of pregnancy and multiple gestation from in vitro fertilization--a new model.
Wheeler C, Cole B, Frishman G, Seifer D, Lovegreen S, Hackett R. Predicting probabilities of pregnancy and multiple gestation from in vitro fertilization--a new model. Obstetrics And Gynecology 1998, 91: 696-700. PMID: 9572213, DOI: 10.1016/s0029-7844(98)00008-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultEmbryo TransferFemaleFertilization in VitroHumansLogistic ModelsMiddle AgedModels, StatisticalPregnancyPregnancy, MultipleConceptsIn vitro fertilizationEmbryo scoreMultiple gestationsProbability of pregnancyIn vitro fertilization programDistribution of pregnanciesEmbryo transferInfant hospitalizationPregnancyGestationIncreasing ageLogistic regressionPatient-specific informationScoresImplantationEmbryosPredicted probabilityAgePatientsInfantsPredicting Probabilities of Pregnancy and Multiple Gestation From In Vitro Fertilization—A New Model
WHEELER C, COLE B, FRISHMAN G, SEIFER D, LOVEGREEN S, HACKETT R. Predicting Probabilities of Pregnancy and Multiple Gestation From In Vitro Fertilization—A New Model. Obstetrics And Gynecology 1998, 91: 696-700. DOI: 10.1097/00006250-199805000-00010.Peer-Reviewed Original ResearchMeSH KeywordsAdultEmbryo TransferFemaleFertilization in VitroHumansLogistic ModelsMiddle AgedModels, StatisticalPregnancyPregnancy, MultipleConceptsMultiple gestationsProbability of pregnancyEmbryo scoreNumber of embryosThird implantationFertilization cyclesInfant HospitalIVF programVitro FertilizationEmbryo transferPregnancySecond implantationLogistic regressionPatient-specific informationGestationP2/P1Embryo scoringHospitalScoresAgeImplantationBest predictorP3/P2Patients
1997
The impact of hydrosalpinx on successful pregnancy in tubal factor infertility treated by in vitro fertilization
Blazar A, Hogan J, Seifer D, Frishman G, Wheeler C, Haning R. The impact of hydrosalpinx on successful pregnancy in tubal factor infertility treated by in vitro fertilization. Fertility And Sterility 1997, 67: 517-520. PMID: 9091340, DOI: 10.1016/s0015-0282(97)80079-9.Peer-Reviewed Original ResearchConceptsTubal factor infertilityTubal diseaseFactor infertilityPregnancy rateCycle cancellation rateSuccess of IVFNumber of oocytesNumber of embryosHydrosalpinx groupRoutine salpingectomyOvarian stimulationOngoing pregnancyImplantation rateSuccessful pregnancyHydrosalpinxMAIN OUTCOMECancellation ratePatientsOocyte fertilizationInfertilityIVFIVF facilityPregnancyMore cyclesFertilization rate
1996
Relaxin secretion in in vitro fertilization pregnancies
Haning R, Goldsmith L, Seifer D, Wheeler C, Frishman G, Sarmento J, Weiss G. Relaxin secretion in in vitro fertilization pregnancies. American Journal Of Obstetrics And Gynecology 1996, 174: 233-240. PMID: 8572013, DOI: 10.1016/s0002-9378(96)70400-3.Peer-Reviewed Original ResearchConceptsHuman chorionic gonadotropinSecretion of relaxinChorionic gonadotropinCorpora luteaSerum estradiolSerum relaxinFunctional statusHuman chorionic gonadotropin (hCG) injectionOvarian hyperstimulation syndromeSerum of womenSecretion of steroidsSerum relaxin concentrationsFertilization pregnanciesHyperstimulation syndromePremature deliveryMultiple gestationsGonadotropin injectionRelaxin secretionMore injectionsRelaxin concentrationsProgesterone concentrationsMultiple linear regression analysisPregnancyGonadotropinSteroid concentrations
1994
Early and late presentation of the ovarian hyperstimulation syndrome: two distinct entities with different risk factors*
Lyons CA, Wheeler CA, Frishman GN, Hackett RJ, Seifer DB, Haning RV. Early and late presentation of the ovarian hyperstimulation syndrome: two distinct entities with different risk factors*. Human Reproduction 1994, 9: 792-799. PMID: 7929724, DOI: 10.1093/oxfordjournals.humrep.a138598.Peer-Reviewed Original ResearchConceptsLate ovarian hyperstimulation syndromeOvarian hyperstimulation syndromeSevere ovarian hyperstimulation syndromeNumber of oocytesHyperstimulation syndromeEarly ovarian hyperstimulation syndromePost-human chorionic gonadotrophinDifferent risk factorsStepwise logistic regressionSeries of casesDay-hCGMultiple gestationsClinical predictorsFertilization cyclesGestational sacEarly pregnancyLate presentationOestradiol concentrationsSerum concentrationsEgg retrievalRisk factorsHigh oestradiolAcute effectsChorionic gonadotrophinRetrospective analysisAberrant estradiol flare despite gonadotropin-releasing hormone-agonist-induced suppression is associated with impaired implantation**Presented at the 48th Annual Meeting of The American Fertility Society, New Orleans, Louisiana, November 2 to 5, 1992.
Penzias A, Lee G, Seifer D, Shamma F, DeCherney A, Reindollar R, Jones E. Aberrant estradiol flare despite gonadotropin-releasing hormone-agonist-induced suppression is associated with impaired implantation**Presented at the 48th Annual Meeting of The American Fertility Society, New Orleans, Louisiana, November 2 to 5, 1992. Fertility And Sterility 1994, 61: 558-560. PMID: 8137986, DOI: 10.1016/s0015-0282(16)56595-9.Peer-Reviewed Original ResearchConceptsAmerican Fertility SocietyBioactive LHDelayed suppressionImpairs implantationOvarian suppressionPituitary suppressionCycle outcomePrognostic markerE2 responseFertility SocietyE2 productionAberrant riseGnRHFurther studiesPrevious reportsRapid suppressionImplantationSuppressionAnnual MeetingLH
1991
Early pituitary desensitization and ovarian suppression with leuprolide acetate is associated with in vitro fertilization-embryo transfer success**Presented in part at the Society for Gynecologic Investigation, San Antonio, Texas, March 20 to 23, 1991.
Seifer D, Thornton K, DeCherney A, Lavy G. Early pituitary desensitization and ovarian suppression with leuprolide acetate is associated with in vitro fertilization-embryo transfer success**Presented in part at the Society for Gynecologic Investigation, San Antonio, Texas, March 20 to 23, 1991. Fertility And Sterility 1991, 56: 500-504. PMID: 1909977, DOI: 10.1016/s0015-0282(16)54548-8.Peer-Reviewed Original ResearchConceptsLeuprolide acetatePituitary desensitizationOvarian suppressionPregnancy ratePg/Group IOvarian hyperstimulationIVF-ETE2 responseGroup IIHuman menopausal gonadotropinControlled ovarian hyperstimulationFertilization-embryo transferSerum estradiol levelsNumber of oocytesHuman chorionic gonadotropinHigher pregnancy ratePg/mLMenopausal gonadotropinIVF patientsRetrospective seriesEstradiol levelsGynecologic InvestigationInfertility practiceMenstrual cycle