2021
Vagus nerve stimulation induces widespread cortical and behavioral activation
Collins L, Boddington L, Steffan P, McCormick D. Vagus nerve stimulation induces widespread cortical and behavioral activation. Current Biology 2021, 31: 2088-2098.e3. PMID: 33740425, DOI: 10.1016/j.cub.2021.02.049.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsArousalCalciumCerebral CortexFemaleMaleMiceNeuronal PlasticityNorepinephrineVagus Nerve StimulationConceptsVagus nerve stimulationCalcium imagingNeuromodulatory systemsVagus nerve transectionAuditory cortical regionsWidefield calcium imagingArousal stateDose-dependent activationNerve transectionVNS effectsNerve stimulationExcitatory activityCortical axonsModulatory pathwaysExcitatory neuronsLight anesthesiaNeurological conditionsTherapeutic mechanismMouse modelStimulation inducesArousal state changesCortical activityCortical stateMotor activityCortical regions
2007
Selective control of cortical axonal spikes by a slowly inactivating K+ current
Shu Y, Yu Y, Yang J, McCormick D. Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 11453-11458. PMID: 17581873, PMCID: PMC2040919, DOI: 10.1073/pnas.0702041104.Peer-Reviewed Original ResearchConceptsSpike durationLayer 5 pyramidal cellsWhole-cell recordingsIntracortical processingPyramidal cellsIntracortical axonsLow dosesDistal axonsAxonal spikesRepetitive dischargesAxonsMembrane potential changesRemarkable differential expressionSomaDifferential expressionAlpha subunitIonic channelsSmall increaseKv1.2 alpha subunitsDurationNeuronsDoses
2005
Role of Synaptic and Intrinsic Membrane Properties in Short-Term Receptive Field Dynamics in Cat Area 17
Nowak L, Sanchez-Vives M, McCormick D. Role of Synaptic and Intrinsic Membrane Properties in Short-Term Receptive Field Dynamics in Cat Area 17. Journal Of Neuroscience 2005, 25: 1866-1880. PMID: 15716423, PMCID: PMC6725929, DOI: 10.1523/jneurosci.3897-04.2005.Peer-Reviewed Original ResearchConceptsHigh-contrast stimulationMembrane potential hyperpolarizationPotential hyperpolarizationCat primary visual cortexRole of synapticIntrinsic membrane propertiesPrimary visual cortexCat area 17Significant reductionHigh-contrast stimuliGray screenArea 17Synaptic mechanismsLack of stimulationVisual cortexArtificial scotomaRF sizeReceptive field dynamicsSine-wave gratingsSingle neuronsStimulationStrong visual stimuliHigh-contrast sine-wave gratingsHyperpolarizationVisual stimuli
1999
Spontaneous activity: signal or noise?
McCormick D. Spontaneous activity: signal or noise? Science 1999, 285: 541-3. PMID: 10447487, DOI: 10.1126/science.285.5427.541.Peer-Reviewed Original Research
1984
Effects of lesions of cerebellar nuclei on conditioned behavioral and hippocampal neuronal responses
Clark G, McCormick D, Lavond D, Thompson R. Effects of lesions of cerebellar nuclei on conditioned behavioral and hippocampal neuronal responses. Brain Research 1984, 291: 125-136. PMID: 6697177, DOI: 10.1016/0006-8993(84)90658-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain MappingCerebellar NucleiConditioning, EyelidHippocampusMaleNeuronal PlasticityNictitating MembranePhysical StimulationRabbitsSoundConceptsCerebellar nucleiNeuronal responsesUnilateral electrolytic lesionsHippocampal neuronal responsesEffects of lesionsIpsilateral sideContralateral sideControl animalsElectrolytic lesionsHippocampal responsesDeep nucleiLesionsLearning deficitsLeft sideRight sideNeural activityTrials of trainingComplete abolition
1982
Concomitant classical conditioning of the rabbit nictitating membrane and eyelid responses: Correlations and implications
McCormick D, Lavond D, Thompson R. Concomitant classical conditioning of the rabbit nictitating membrane and eyelid responses: Correlations and implications. Physiology & Behavior 1982, 28: 769-775. PMID: 7100278, DOI: 10.1016/0031-9384(82)90192-5.Peer-Reviewed Original Research