2024
Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8+ T-Cell Infiltration in Murine Hepatocellular Carcinoma.
Shewarega A, Santana J, Nam D, Berz A, Tefera J, Kahl V, Mishra S, Coman D, Duncan J, Roberts S, Wetter A, Madoff D, Chapiro J. Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8+ T-Cell Infiltration in Murine Hepatocellular Carcinoma. Radiology 2024, 310: e232365. PMID: 38349244, PMCID: PMC10902598, DOI: 10.1148/radiol.232365.Peer-Reviewed Original ResearchConceptsT cell infiltrationCD8<sup>+</sup> T cellsMatrix metalloproteinase inhibitionT cellsHepatocellular carcinomaMatrix metalloproteinase inhibitorsMatrix metalloproteinasesResidual tumorCXCR3<sup>+</sup> CD8<sup>+</sup> T cellsCytotoxic CD8<sup>+</sup> T cell infiltrationIntratumoral CD8+ T cell infiltrationCD8+ T cell infiltrationCD8<sup>+</sup> T cell infiltrationMouse model of hepatocellular carcinomaEarly-stage hepatocellular carcinomaImage-guided tumor ablationUnpaired Student's <i>t</i> testModel of hepatocellular carcinomaFirst-line therapyMurine hepatocellular carcinomaT cell subsetsTumor-associated macrophagesMurine HCC modelLocal immune responseFemale BALB/c mice
2020
Multicenter Study of Metastatic Lung Tumors Targeted by Interventional Cryoablation Evaluation (SOLSTICE)
Callstrom MR, Woodrum DA, Nichols FC, Palussiere J, Buy X, Suh RD, Abtin FG, Pua BB, Madoff DC, Bagla SL, Papadouris DC, Fernando HC, Dupuy DE, Healey TT, Moore WH, Bilfinger TV, Solomon SB, Yarmohammadi H, Krebs HJ, Fulp CJ, Hakime A, Tselikas L, de Baere T. Multicenter Study of Metastatic Lung Tumors Targeted by Interventional Cryoablation Evaluation (SOLSTICE). Journal Of Thoracic Oncology 2020, 15: 1200-1209. PMID: 32151777, PMCID: PMC9201766, DOI: 10.1016/j.jtho.2020.02.022.Peer-Reviewed Original ResearchConceptsOverall survival ratePulmonary metastasesPercutaneous cryoablationSurvival rateLocal recurrence-free survivalGrade 4 eventsPleural catheter placementMetastatic lung tumorsPhase 2 studyKaplan-Meier methodRecurrence-free survivalRate of pneumothoraxKaplan-Meier estimatesKey inclusion criteriaQuality of lifeComplication eventsExtrapulmonary cancersMetastatic diseasePerformance statusInitial treatmentRecurrent tumorsCatheter placementLung metastasesMulticenter studyCryoablation treatment
2018
Percutaneous Cryoablation for the Management of Chronic Pain Secondary to Locally Recurrent Rectal Cancer with Bowel and Nerve Root Involvement
Cornman-Homonoff J, Formenti SC, Chachoua A, Madoff DC. Percutaneous Cryoablation for the Management of Chronic Pain Secondary to Locally Recurrent Rectal Cancer with Bowel and Nerve Root Involvement. Journal Of Vascular And Interventional Radiology 2018, 29: 1296-1298. PMID: 30146202, DOI: 10.1016/j.jvir.2018.02.022.Peer-Reviewed Case Reports and Technical Notes
2006
Update on the Management of Neuroendocrine Hepatic Metastases
Madoff DC, Gupta S, Ahrar K, Murthy R, Yao JC. Update on the Management of Neuroendocrine Hepatic Metastases. Journal Of Vascular And Interventional Radiology 2006, 17: 1235-1250. PMID: 16923972, DOI: 10.1097/01.rvi.0000232177.57950.71.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsBrachytherapyCatheter AblationChemoembolization, TherapeuticClinical Trials as TopicCryosurgeryEthanolHepatectomyHumansLiver NeoplasmsLiver TransplantationNeoplasms, Unknown PrimaryNeuroendocrine TumorsPractice Guidelines as TopicRadiology, InterventionalTomography, X-Ray ComputedTreatment OutcomeConceptsNeuroendocrine tumorsHepatic metastasesLong indolent courseYear of diagnosisMajority of patientsTime of diagnosisCare of patientsUnusual clinical presentationNeuroendocrine hepatic metastasesTumor growth patternMost patientsIndolent courseClinical presentationRespiratory tractPatientsOrgan systemsMetastasisDiagnosisImage-guided interventionsGrowth patternMalignancyTumorsTractCare